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| | cysE1nif | Nitrogen fixation serine O-acetyltransferase CysE1. (265 aa) |
| | zwf-4 | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (485 aa) |
| | pycA | Pyruvate carboxylase subunit A. (471 aa) |
| | pycB | Pyruvate carboxylase subunit B. (599 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (281 aa) |
| | fdhA | Formate dehydrogenase, alpha subunit. (1018 aa) |
| | fdhH | Formate dehydrogenase, beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (297 aa) |
| | fdhI | Formate dehydrogenase, gamma subunit. (215 aa) |
| | mqo | Malate:quinone-oxidoreductase. (539 aa) |
| | glk-2 | Glucokinase; Belongs to the bacterial glucokinase family. (322 aa) |
| | cooS | Carbon-monoxide dehydrogenase, catalytic subunit. (632 aa) |
| | cooF | Iron-sulfur cluster-binding protein CooF. (185 aa) |
| | pgm-1 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (532 aa) |
| | tktA-3 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (386 aa) |
| | fba | Class II fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | glcB | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (724 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (153 aa) |
| | ACO76983.1 | Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa) |
| | serB | Phosphoserine phosphatase. (404 aa) |
| | ACO77303.1 | Methylmalonate-semialdehyde dehydrogenase. (501 aa) |
| | pdhA-2 | TPP-dependent dehydrogenase, E1 component alpha subunit, E1_dh family; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (362 aa) |
| | ACO77309.1 | TPP-dependent dehydrogenase, E1 component beta subunit. (328 aa) |
| | ACO77310.1 | Dihydrolipoamide acetyltransferase. (367 aa) |
| | mmsA | Methylmalonate-semialdehyde dehydrogenase. (498 aa) |
| | aat1 | Beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (416 aa) |
| | fadB1 | Fatty acid oxidation complex alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (715 aa) |
| | gapB | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (461 aa) |
| | edd-1 | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa) |
| | glk-1 | Glucokinase; Belongs to the bacterial glucokinase family. (322 aa) |
| | pgl-1 | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (238 aa) |
| | eda-2 | KDPG aldolase. (212 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | ACO77853.1 | acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa) |
| | ACO77859.1 | acetyl-CoA hydrolase/transferase family. (498 aa) |
| | ACO77883.1 | acetyl-CoA hydrolase/transferase family protein. (498 aa) |
| | ACO77948.1 | 3-hydroxyacyl-CoA dehydrogenase. (697 aa) |
| | ACO77949.1 | Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | pgl-2 | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (237 aa) |
| | pgi-1 | Glucose-6-phosphate isomerase; Belongs to the GPI family. (554 aa) |
| | ppdK | Pyruvate, phosphate dikinase. (539 aa) |
| | ACO78086.1 | Acetyl-CoA hydrolase/transferase. (498 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (895 aa) |
| | cysE3 | Serine O-acetyltransferase. (327 aa) |
| | rpiB | Ribose 5-phosphate isomerase B protein. (157 aa) |
| | talB-1 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (322 aa) |
| | tktA-1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (672 aa) |
| | pykA-2 | Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | eno-2 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (437 aa) |
| | ACO78415.1 | Thiolase protein; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | gntK-1 | Gluconokinase. (174 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (790 aa) |
| | pfkB | 6-phosphofructokinase II; Belongs to the carbohydrate kinase PfkB family. (312 aa) |
| | acnB | Aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (869 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | phbA | Polyhydroxybutyrate biosynthetic beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | phbB | Acetoacetl-CoA reductase in PHB biosynthesis. (247 aa) |
| | ACO78706.1 | 3-hydroxybutyryl-CoA dehydrogenase. (291 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | gcvP2 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa) |
| | sdaA | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | gcvT3 | Glycine cleavage system T protein. (374 aa) |
| | fumC1 | Fumarate hydratase class II protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa) |
| | ACO78895.1 | Glyceraldehyde-3-phosphate dehydrogenase. (541 aa) |
| | eno-1 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (437 aa) |
| | pykA-1 | Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | eda-1 | KDPG aldolase. (212 aa) |
| | zwf-1 | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa) |
| | edd-2 | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa) |
| | gntK-2 | Gluconokinase. (175 aa) |
| | pgm-2 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa) |
| | icd | Isocitrate dehydrogenase, NADP-dependent, Icd; Belongs to the monomeric-type IDH family. (741 aa) |
| | ACO79014.1 | Isocitrate lyase. (531 aa) |
| | sucC | Succinyl-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa) |
| | sucC-2 | Succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | lpdA | Dihydrolipoamide dehydrogenase. (477 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (399 aa) |
| | sucA | 2-oxoglutarate dehydrogenase, E1 component. (943 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur subunit. (233 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit. (439 aa) |
| | sdhD | Succinate dehydrogenase cytochrome b556 small membrane subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (122 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b556 large membrane subunit. (77 aa) |
| | gltA | Citrate synthase I; Belongs to the citrate synthase family. (427 aa) |
| | gcvT2 | Glycine cleavage system T protein. (365 aa) |
| | talB-3 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (308 aa) |
| | cysK | Cysteine synthase K/M:Cysteine synthase K; Belongs to the cysteine synthase/cystathionine beta- synthase family. (325 aa) |
| | ACO79529.1 | 3-hydroxyacyl-CoA dehydrogenase, NAD-binding domain protein. (294 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (311 aa) |
| | ACO79583.1 | KHG/KDPG aldolase. (216 aa) |
| | acsA1 | acetate-CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (653 aa) |
| | pta-1 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (712 aa) |
| | ackA-1 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa) |
| | fumC2 | Fumarate hydratase class II protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | pykA-6 | Pyruvate kinase; Belongs to the pyruvate kinase family. (483 aa) |
| | fumB | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (503 aa) |
| | fghA | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (281 aa) |
| | ACO80015.1 | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (371 aa) |
| | eno-6 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (878 aa) |
| | ACO80114.1 | D-isomer specific 2-hydroxyacid dehydrogenase. (325 aa) |
| | cysE2 | Serine O-acetyltransferase. (259 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | ackA-2 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa) |
| | pta-2 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (691 aa) |
| | ACO80256.1 | D-glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa) |
| | mqo-2 | Malate:quinone-oxidoreductase. (510 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa) |
| | acoC | Dihydrolipoamide acetyltransferase,acetoin dehydrogeanse E2 component, AcoC. (370 aa) |
| | pgi-3 | Glucose-6-phosphate isomerase; Belongs to the GPI family. (554 aa) |
| | acsA2 | Acetate CoA ligase AcsA; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa) |
| | maeB2 | Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). (414 aa) |
| | glcB-2 | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa) |
| | eno-3 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (438 aa) |
| | pykA-3 | Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | pta-3 | Phosphate acetyltransferase. (317 aa) |
| | ackA-3 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa) |
| | aceE | Pyruvate dehydrogenase, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (889 aa) |
| | lpd | Pyruvate dehydrogenase complex, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (640 aa) |
| | maeB | Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). (422 aa) |
| | fbp | Fructose-1,6-bisphosphatase. (337 aa) |
| | eno-4 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (439 aa) |
| | tpiA-2 | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pdhB | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (323 aa) |
| | pdhA | Pyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (338 aa) |
| | ACO80729.1 | Ribose-phosphate pyrophosphokinase. (326 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa) |
| | gcvP1 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) |
| | gcvT | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (360 aa) |
| | ACO80896.1 | Catalase protein; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (335 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa) |
| | rpiA-2 | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (226 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa) |
| | tpiA-3 | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (246 aa) |
| | ACO81086.1 | Aldehyde dehydrogenase. (541 aa) |
| | pykA-5 | Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | iolA | Malonate/methylmalonate semialdehyde dehydrogenase. (499 aa) |
| | pykA-4 | Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
