STRINGSTRING
Nwi_0711 Nwi_0711 Nwi_0685 Nwi_0685 Nwi_0684 Nwi_0684 Nwi_0671 Nwi_0671 Nwi_0669 Nwi_0669 Nwi_0668 Nwi_0668 Nwi_0611 Nwi_0611 Nwi_0610 Nwi_0610 mnmA mnmA Nwi_0595 Nwi_0595 clpB clpB Nwi_0577 Nwi_0577 ftsE ftsE Nwi_0535 Nwi_0535 Nwi_0532 Nwi_0532 Nwi_0526 Nwi_0526 Nwi_0515 Nwi_0515 pstB pstB Nwi_0505 Nwi_0505 mutS mutS acsA acsA Nwi_0462 Nwi_0462 Nwi_0458 Nwi_0458 nadD nadD proB proB atpC atpC atpD atpD atpG atpG atpA atpA priA priA sucC sucC Nwi_0418 Nwi_0418 Nwi_0415 Nwi_0415 Nwi_0403 Nwi_0403 Nwi_0401 Nwi_0401 aroK aroK accA accA secA secA Nwi_0379 Nwi_0379 dnaX dnaX Nwi_0359 Nwi_0359 Nwi_0353 Nwi_0353 pckA pckA Nwi_0347 Nwi_0347 Nwi_0346 Nwi_0346 Nwi_0338 Nwi_0338 Nwi_0332 Nwi_0332 Nwi_0327 Nwi_0327 ccmA ccmA Nwi_0314 Nwi_0314 Nwi_0299 Nwi_0299 Nwi_0298 Nwi_0298 Nwi_0292 Nwi_0292 glpK glpK Nwi_0270 Nwi_0270 Nwi_0264 Nwi_0264 Nwi_0251 Nwi_0251 trpS trpS cmk cmk dnaJ dnaJ dnaK dnaK Nwi_0187 Nwi_0187 Nwi_0182 Nwi_0182 Nwi_0174 Nwi_0174 lysS lysS hslU hslU hisE hisE coaA coaA Nwi_0118 Nwi_0118 gshB gshB Nwi_0110 Nwi_0110 coaE coaE Nwi_0102 Nwi_0102 rho rho Nwi_0095 Nwi_0095 leuS leuS Nwi_0083 Nwi_0083 pheS pheS pheT pheT accD accD Nwi_0052 Nwi_0052 Nwi_0050 Nwi_0050 Nwi_0015 Nwi_0015 gyrB gyrB recF recF dnaA dnaA Nwi_3134 Nwi_3134 Nwi_3097 Nwi_3097 Nwi_3077 Nwi_3077 argB argB Nwi_3049 Nwi_3049 Nwi_3019 Nwi_3019 Nwi_3002 Nwi_3002 Nwi_2946 Nwi_2946 Nwi_2927 Nwi_2927 Nwi_2888 Nwi_2888 Nwi_2877 Nwi_2877 Nwi_2842 Nwi_2842 htpG htpG argG argG cysC cysC Nwi_2763 Nwi_2763 cysA cysA Nwi_2746 Nwi_2746 Nwi_2743 Nwi_2743 pgk pgk Nwi_2731 Nwi_2731 ruvA ruvA ruvB ruvB tilS tilS ftsH ftsH Nwi_2709 Nwi_2709 Nwi_2696 Nwi_2696 Nwi_2693 Nwi_2693 thrB thrB ndvA ndvA Nwi_2670 Nwi_2670 Nwi_2645 Nwi_2645 Nwi_2626 Nwi_2626 smc smc ispE ispE glyQ glyQ glyS glyS groL3 groL3 groS-3 groS-3 hisG hisG lpxK lpxK purD purD mutL mutL ileS ileS Nwi_2541 Nwi_2541 hisS hisS ychF ychF prs prs uvrB uvrB Nwi_2485 Nwi_2485 Nwi_2470 Nwi_2470 Nwi_2455 Nwi_2455 carB carB carA carA bioD bioD Nwi_2392 Nwi_2392 Nwi_2378 Nwi_2378 Nwi_2361 Nwi_2361 Nwi_2360 Nwi_2360 miaA miaA Nwi_2339 Nwi_2339 hmuV hmuV Nwi_2240 Nwi_2240 Nwi_2235 Nwi_2235 Nwi_2212 Nwi_2212 Nwi_2211 Nwi_2211 Nwi_2203 Nwi_2203 groL2 groL2 groS-2 groS-2 Nwi_2153 Nwi_2153 guaA guaA Nwi_2131 Nwi_2131 Nwi_2129 Nwi_2129 groS groS groL1 groL1 Nwi_2109 Nwi_2109 Nwi_2098 Nwi_2098 Nwi_2097 Nwi_2097 Nwi_2089 Nwi_2089 Nwi_2077 Nwi_2077 Nwi_2074 Nwi_2074 Nwi_2073 Nwi_2073 macB macB thrS thrS radA radA Nwi_2013 Nwi_2013 gatC gatC gatA gatA gatB gatB Nwi_1978 Nwi_1978 Nwi_1976 Nwi_1976 Nwi_1954 Nwi_1954 Nwi_1949 Nwi_1949 ackA ackA Nwi_1941 Nwi_1941 parC parC Nwi_1904 Nwi_1904 Nwi_1903 Nwi_1903 nnrE nnrE clpX clpX lon lon proS proS lolD lolD pyrH pyrH gltX gltX glnS glnS pyrG pyrG argS argS gyrA gyrA coaD coaD serS serS Nwi_1765 Nwi_1765 Nwi_1753 Nwi_1753 Nwi_1736 Nwi_1736 nrdR nrdR thiL thiL panC panC Nwi_1700 Nwi_1700 Nwi_1695 Nwi_1695 gmk gmk Nwi_1673 Nwi_1673 tyrS tyrS anmK anmK Nwi_1663 Nwi_1663 Nwi_1660 Nwi_1660 Nwi_1657 Nwi_1657 parE parE Nwi_1642 Nwi_1642 Nwi_1604 Nwi_1604 ndk ndk purM purM ppk ppk aspS aspS Nwi_1575 Nwi_1575 uvrA uvrA Nwi_1526 Nwi_1526 Nwi_1515 Nwi_1515 mfd mfd pxpA pxpA Nwi_1502 Nwi_1502 Nwi_1501 Nwi_1501 Nwi_1493 Nwi_1493 Nwi_1486 Nwi_1486 tmk tmk metG metG queC queC Nwi_1447 Nwi_1447 Nwi_1446 Nwi_1446 ntrC ntrC Nwi_1444 Nwi_1444 valS valS Nwi_1415 Nwi_1415 Nwi_1392 Nwi_1392 adk adk nadK nadK purL purL purQ purQ purS purS purC purC alaS alaS recA recA Nwi_1255 Nwi_1255 Nwi_1248 Nwi_1248 Nwi_1233 Nwi_1233 cysS cysS nadE nadE Nwi_1215 Nwi_1215 Nwi_1212 Nwi_1212 glnE glnE hldE hldE Nwi_1064 Nwi_1064 Nwi_1061 Nwi_1061 ftsA ftsA Nwi_1055 Nwi_1055 murC murC murD murD murF murF murE murE Nwi_1030 Nwi_1030 Nwi_1029 Nwi_1029 glk glk Nwi_1012 Nwi_1012 potA potA purK purK Nwi_0992 Nwi_0992 Nwi_0986 Nwi_0986 Nwi_0962 Nwi_0962 selO selO Nwi_0933 Nwi_0933 Nwi_0914 Nwi_0914 Nwi_0911 Nwi_0911 Nwi_0897 Nwi_0897 Nwi_0846 Nwi_0846 Nwi_0833 Nwi_0833 Nwi_0820 Nwi_0820 Nwi_0810 Nwi_0810 Nwi_0752 Nwi_0752 Nwi_0748 Nwi_0748
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Nwi_0711Protein of unknown function DUF59. (135 aa)
Nwi_0685Aliphatic sulfonate ABC transporter ATP-binding protein. (88 aa)
Nwi_0684ABC transporter, ATPase subunit. (151 aa)
Nwi_0671ABC-type nitrate/sulfonate/bicarbonate transport system ATPase component. (279 aa)
Nwi_0669Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family; TC 3.A.1.4.-. (234 aa)
Nwi_0668Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family; TC 3.A.1.4.-. (272 aa)
Nwi_0611ABC transporter, transmembrane region. (573 aa)
Nwi_0610Conserved hypothetical protein. (324 aa)
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (400 aa)
Nwi_0595Two component, sigma54 specific, transcriptional regulator, Fis family. (459 aa)
clpBAAA ATPase; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (891 aa)
Nwi_0577Protein of unknown function DUF214. (314 aa)
ftsEABC transporter, ATPase subunit; Part of the ABC transporter FtsEX involved in cellular division. (219 aa)
Nwi_0535ABC transporter, transmembrane region. (744 aa)
Nwi_0532Plasmid segregation oscillating ATPase ParF. (234 aa)
Nwi_0526ATPase FliI/YscN. (441 aa)
Nwi_0515Conserved hypothetical protein. (418 aa)
pstBPhosphate ABC transporter ATP-binding protein, PhoT family; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (273 aa)
Nwi_0505Signal transduction histidine kinase. (417 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (888 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
Nwi_0462ATP dependent DNA ligase. (594 aa)
Nwi_0458ABC transporter, ATPase subunit. (270 aa)
nadDCytidylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (379 aa)
atpCATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (135 aa)
atpDATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (476 aa)
atpGATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa)
atpAATP synthase F1 subcomplex alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (510 aa)
priAReplication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (738 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
Nwi_0418AFG1-like ATPase. (394 aa)
Nwi_0415ABC transporter, ATPase subunit. (240 aa)
Nwi_0403Cobaltochelatase CobS subunit. (332 aa)
Nwi_0401Heat shock protein DnaJ. (232 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (214 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa)
secAProtein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (953 aa)
Nwi_0379Aspartate kinase; Belongs to the aspartokinase family. (417 aa)
dnaXDNA polymerase III gamma/tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (611 aa)
Nwi_0359ATP-dependent helicase HrpB. (872 aa)
Nwi_0353ATP-dependent DNA ligase LigD polymerase module. (913 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (538 aa)
Nwi_0347Signal transduction histidine kinase. (611 aa)
Nwi_0346Hpr(Ser) kinase/phosphatase. (169 aa)
Nwi_0338Molybdate ABC transporter, ATP-binding protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (221 aa)
Nwi_0332ABC transporter, ATPase subunit. (267 aa)
Nwi_0327ABC transporter, transmembrane region. (587 aa)
ccmAHeme exporter protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (200 aa)
Nwi_0314DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (476 aa)
Nwi_0299Pilus assembly protein cpaE. (421 aa)
Nwi_0298Type II secretion system protein E. (488 aa)
Nwi_0292ABC transporter, ATPase subunit; Belongs to the ABC transporter superfamily. (545 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (519 aa)
Nwi_0270DEAD/DEAH box helicase. (790 aa)
Nwi_0264Conserved hypothetical protein. (452 aa)
Nwi_0251Superfamily II DNA/RNA helicase, SNF2 family. (541 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (347 aa)
cmkCytidylate kinase. (212 aa)
dnaJHeat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (378 aa)
dnaKHeat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. (630 aa)
Nwi_0187ATP dependent helicase, Lhr family. (835 aa)
Nwi_0182Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (456 aa)
Nwi_0174ABC transporter, ATPase subunit. (332 aa)
lysSlysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (543 aa)
hslUHeat shock protein HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (433 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (116 aa)
coaAPantothenate kinase. (318 aa)
Nwi_0118Mg chelatase-related protein. (512 aa)
gshBGlutathione synthase; Belongs to the prokaryotic GSH synthase family. (317 aa)
Nwi_0110Histidine kinase. (446 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa)
Nwi_0102Protein of unknown function DUF299; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (280 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (421 aa)
Nwi_0095Chromosome segregation ATPase. (289 aa)
leuSleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (883 aa)
Nwi_0083DNA translocase FtsK. (833 aa)
pheSphenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (369 aa)
pheTphenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (812 aa)
accDacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (319 aa)
Nwi_0052Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. (442 aa)
Nwi_0050DNA helicase/exodeoxyribonuclease V, subunit A; Belongs to the helicase family. UvrD subfamily. (1202 aa)
Nwi_0015PhoH-like protein. (349 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (813 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (385 aa)
dnaAChromosomal replication initiator protein, DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (475 aa)
Nwi_3134Heavy metal translocating P-type ATPase. (712 aa)
Nwi_3097Hypothetical protein. (49 aa)
Nwi_3077Signal transduction histidine kinase. (492 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (298 aa)
Nwi_3049ABC transporter, ATPase subunit. (260 aa)
Nwi_3019YcjX-like protein. (502 aa)
Nwi_3002Hypothetical protein. (312 aa)
Nwi_2946Response regulator receiver. (135 aa)
Nwi_2927CbbX like protein. (304 aa)
Nwi_2888Ribonucleotide reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (969 aa)
Nwi_2877Conserved hypothetical protein. (319 aa)
Nwi_2842IstB-like ATP-binding protein. (168 aa)
htpGHeat shock protein Hsp90; Molecular chaperone. Has ATPase activity. (637 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa)
cysCSulfate adenylyltransferase subunit 1 / adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (641 aa)
Nwi_2763Sulfate adenylyltransferase subunit 2. (268 aa)
cysASulphate transport system permease protein 1; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (349 aa)
Nwi_2746ABC transporter, ATP-binding/permease protein. (627 aa)
Nwi_2743Conserved hypothetical protein. (358 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (398 aa)
Nwi_27315-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (195 aa)
ruvAHolliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (205 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (348 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (371 aa)
ftsHMembrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (640 aa)
Nwi_2709Pyruvate phosphate dikinase. (1028 aa)
Nwi_2696Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (328 aa)
Nwi_2693Phosphoribulokinase/uridine kinase. (290 aa)
thrBHomoserine kinase; Belongs to the pseudomonas-type ThrB family. (326 aa)
ndvAGlucan exporter ATP-binding protein; Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). (626 aa)
Nwi_2670ABC transporter, ATPase subunit. (236 aa)
Nwi_2645Gluconate kinase, SKI family. (172 aa)
Nwi_2626ATPase associated with various cellular activities, AAA_3. (337 aa)
smcCondensin subunit Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1168 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (308 aa)
glyQglycyl-tRNA synthetase alpha chain. (314 aa)
glySglycyl-tRNA synthetase beta chain. (727 aa)
groL3Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
groS-3Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (98 aa)
hisGATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (325 aa)
lpxKlipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (337 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (426 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (603 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). (999 aa)
Nwi_2541FMN adenylyltransferase; Belongs to the ribF family. (327 aa)
hisShistidyl-tRNA synthetase. (547 aa)
ychFConserved hypothetical protein 92; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (365 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (1032 aa)
Nwi_2485ABC transporter, ATPase subunit. (550 aa)
Nwi_2470Helix-turn-helix, Fis-type. (84 aa)
Nwi_2455Cobyrinic acid a,c-diamide synthase. (226 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1154 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (396 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (213 aa)
Nwi_2392LPS biosynthesis protein. (392 aa)
Nwi_2378Methionine adenosyltransferase; Belongs to the AdoMet synthase family. (398 aa)
Nwi_2361ABC transporter, ATPase subunit. (306 aa)
Nwi_2360ATP-dependent DNA helicase, Rep family. (816 aa)
miaAtRNA isopentenyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (314 aa)
Nwi_2339ABC transporter, ATPase subunit. (263 aa)
hmuVABC transporter, ATPase subunit; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. (269 aa)
Nwi_2240methylmalonyl-CoA mutase metallochaperone MeaB. (326 aa)
Nwi_22357, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (163 aa)
Nwi_2212Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family; TC 3.A.1.4.-. (247 aa)
Nwi_2211Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family; TC 3.A.1.4.-. (278 aa)
Nwi_2203AAA ATPase. (314 aa)
groL2Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (545 aa)
groS-2Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (105 aa)
Nwi_2153ABC transporter, ATPase subunit. (602 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (535 aa)
Nwi_2131DEAD/DEAH box helicase. (1099 aa)
Nwi_2129Conserved hypothetical protein. (353 aa)
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (104 aa)
groL1Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (542 aa)
Nwi_2109Filamentation induced by cAMP protein Fic. (391 aa)
Nwi_2098Conjugal transfer protein trbE. (401 aa)
Nwi_2097Type IV secretion system protein VirB4. (156 aa)
Nwi_2089AAA ATPase. (336 aa)
Nwi_2077IstB-like ATP-binding protein. (356 aa)
Nwi_2074ABC transporter, ATPase subunit. (276 aa)
Nwi_2073Periplasmic binding protein. (343 aa)
macBABC transporter, ATPase subunit; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (645 aa)
thrSSer-tRNA(Thr) hydrolase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (686 aa)
radADNA replication and repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (486 aa)
Nwi_2013DnaB helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (496 aa)
gatCaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (95 aa)
gatAaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (491 aa)
gatBaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (494 aa)
Nwi_1978Plasmid segregation oscillating ATPase ParF. (211 aa)
Nwi_1976ATPase associated with various cellular activities, AAA_5. (307 aa)
Nwi_1954Conserved hypothetical protein. (343 aa)
Nwi_1949Heavy metal translocating P-type ATPase. (665 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (589 aa)
Nwi_1941CRISPR-associated helicase, Cas3 family. (744 aa)
parCDNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (749 aa)
Nwi_1904L-glutamine synthetase. (469 aa)
Nwi_1903Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. (112 aa)
nnrEConserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...] (499 aa)
clpXClpX, ATPase regulatory subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa)
lonATP-dependent proteinase, Serine peptidase, MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (808 aa)
proSProlyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro); Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily. (439 aa)
lolDABC transporter, ATPase subunit; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (232 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (496 aa)
glnSglutaminyl-tRNA synthetase. (559 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa)
argSarginyl-tRNA synthetase. (597 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (913 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (497 aa)
Nwi_1765Serine/threonine protein kinase. (366 aa)
Nwi_1753acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa)
Nwi_1736Biotin carboxylase / biotin carboxyl carrier protein. (671 aa)
nrdRProtein of unknown function DUF193; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (160 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa)
Nwi_1700Heat shock protein DnaJ. (298 aa)
Nwi_1695AAA ATPase; Belongs to the ClpA/ClpB family. (801 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (219 aa)
Nwi_1673ABC transporter, ATPase subunit. (625 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (417 aa)
anmKProtein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (366 aa)
Nwi_1663FeS assembly ATPase SufC. (249 aa)
Nwi_1660Protein of unknown function DUF59. (126 aa)
Nwi_1657DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (483 aa)
parEDNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (685 aa)
Nwi_1642tRNA synthetase, class II (D, K and N). (347 aa)
Nwi_1604Carbamoyl-phosphate synthetase large chain. (668 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (357 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (733 aa)
aspSaspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa)
Nwi_1575Polyphosphate glucokinase. (236 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (993 aa)
Nwi_1526Amino acid ABC transporter ATP-binding protein, PAAT family; TC 3.A.1.3.-. (247 aa)
Nwi_1515ATP-dependent DNA helicase RecG. (699 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1174 aa)
pxpALamB/YcsF; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (255 aa)
Nwi_1502Allophanate hydrolase subunit 2. (339 aa)
Nwi_1501Conserved hypothetical protein. (244 aa)
Nwi_1493TOPRIM protein. (437 aa)
Nwi_1486RecA-family ATPase. (796 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (230 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (692 aa)
queCpreQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (238 aa)
Nwi_1447Two component, sigma54 specific, transcriptional regulator, Fis family. (456 aa)
Nwi_1446Multi-sensor signal transduction histidine kinase. (766 aa)
ntrCNitrogen metabolism transcriptional regulator, NtrC, Fis family; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (479 aa)
Nwi_1444Signal transduction histidine kinase, nitrogen specific, NtrB. (391 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (952 aa)
Nwi_1415Lipopolysaccharide biosynthesis. (715 aa)
Nwi_1392Recombination protein MgsA. (443 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (206 aa)
nadKATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (261 aa)
purLPhosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (737 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (233 aa)
purSPhosphoribosylformylglycinamidine synthetase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] (79 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (265 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (891 aa)
recARecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (362 aa)
Nwi_1255DEAD/DEAH box helicase. (811 aa)
Nwi_1248Protein of unknown function DUF87. (617 aa)
Nwi_1233ABC transporter, transmembrane region. (652 aa)
cysScysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (477 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (583 aa)
Nwi_1215ATP-binding protein involved in chromosome partitioning; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (379 aa)
Nwi_1212Signal transduction histidine kinase. (536 aa)
glnEGlutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (987 aa)
hldED-alpha,beta-D-heptose 7-phosphate 1-kinase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (488 aa)
Nwi_1064ABC transporter, transmembrane region. (602 aa)
Nwi_1061DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. (561 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (440 aa)
Nwi_1055D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (330 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (467 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (466 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (476 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (485 aa)
Nwi_1030Conserved hypothetical protein. (135 aa)
Nwi_1029PAS/PAC sensor signal transduction histidine kinase. (511 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (325 aa)
Nwi_1012PAS/PAC sensor signal transduction histidine kinase. (1005 aa)
potASpermidine/putrescine ABC transporter ATP-binding subunit; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (382 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (370 aa)
Nwi_0992Two component, sigma54 specific, transcriptional regulator, Fis family. (498 aa)
Nwi_0986Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
Nwi_0962Type I secretion system ATPase, PrtD. (668 aa)
selOProtein of unknown function UPF0061; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). (505 aa)
Nwi_0933Conserved hypothetical protein. (187 aa)
Nwi_0914ABC transporter, ATPase subunit. (251 aa)
Nwi_0911Heavy metal translocating P-type ATPase. (831 aa)
Nwi_0897Conserved hypothetical protein. (513 aa)
Nwi_0846Possible replication protein A. (287 aa)
Nwi_0833Cobyrinic acid a,c-diamide synthase. (350 aa)
Nwi_0820Plasmid and phage replicative helicase. (743 aa)
Nwi_0810Phage terminase GpA. (614 aa)
Nwi_0752ATP:cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
Nwi_0748glutamyl-tRNA synthetase, class Ic; Belongs to the class-I aminoacyl-tRNA synthetase family. (290 aa)
Your Current Organism:
Nitrobacter winogradskyi
NCBI taxonomy Id: 323098
Other names: N. winogradskyi Nb-255, Nitrobacter winogradskyi Nb-255, Nitrobacter winogradskyi str. Nb-255, Nitrobacter winogradskyi strain Nb-255
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