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Noc_0109 Noc_0109 ubiD ubiD Noc_0213 Noc_0213 Noc_0228 Noc_0228 hemC hemC Noc_0503 Noc_0503 Noc_0504 Noc_0504 Noc_0505 Noc_0505 hemA hemA ispE ispE hemL hemL Noc_0605 Noc_0605 dxr dxr ispD ispD ispF ispF cysG cysG Noc_0918 Noc_0918 coq7 coq7 Noc_0999 Noc_0999 Noc_1042 Noc_1042 ubiA ubiA Noc_1231 Noc_1231 phnW phnW Noc_1316 Noc_1316 Noc_1317 Noc_1317 Noc_1318 Noc_1318 Noc_1320 Noc_1320 Noc_1321 Noc_1321 Noc_1322 Noc_1322 Noc_1323 Noc_1323 Noc_1326 Noc_1326 Noc_1375 Noc_1375 Noc_1376 Noc_1376 hemH hemH Noc_1586 Noc_1586 dxs dxs ispH ispH Noc_1745 Noc_1745 Noc_1747 Noc_1747 Noc_1748 Noc_1748 ispG ispG Noc_2011 Noc_2011 Noc_2037 Noc_2037 Noc_2232 Noc_2232 ubiG ubiG ubiE ubiE Noc_2344 Noc_2344 ubiB ubiB ubiX ubiX Noc_2574 Noc_2574 Noc_2580 Noc_2580 Noc_2581 Noc_2581 Noc_2749 Noc_2749 hemF hemF Noc_2849 Noc_2849 hemE hemE Noc_3032 Noc_3032
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Noc_0109Formate/nitrite transporter. (306 aa)
ubiD3-octaprenyl-4hydroxybenzoate decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (487 aa)
Noc_0213CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (197 aa)
Noc_0228Conserved hypothetical protein 701. (139 aa)
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa)
Noc_0503uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (265 aa)
Noc_0504Protein of unknown function DUF513, hemX. (582 aa)
Noc_0505HemY-like protein. (427 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (420 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (280 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (430 aa)
Noc_0605Rubredoxin-type Fe(Cys)4 protein. (54 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (393 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (234 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa)
cysGPrecorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (468 aa)
Noc_0918Hypothetical protein. (80 aa)
coq7Putative ubiquinone biosynthesis protein; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. (214 aa)
Noc_0999NAD-dependent epimerase/dehydratase. (329 aa)
Noc_1042Squalene/phytoene synthase. (286 aa)
ubiA4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (285 aa)
Noc_1231Hypothetical protein. (235 aa)
phnWAminotransferase, class V; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. (356 aa)
Noc_1316Thiamine pyrophosphate enzyme. (384 aa)
Noc_13172,3-dimethylmalate lyase. (556 aa)
Noc_1318Conserved hypothetical protein. (256 aa)
Noc_1320Terpene synthase/Squalene cyclase. (659 aa)
Noc_1321Farnesyl-diphosphate farnesyltransferase. (366 aa)
Noc_1322Hypothetical protein. (80 aa)
Noc_1323Hypothetical protein. (302 aa)
Noc_1326Sterol desaturase-related protein. (270 aa)
Noc_1375Lysophospholipase. (326 aa)
Noc_1376Conserved hypothetical protein. (181 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (368 aa)
Noc_1586Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. (221 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (640 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (320 aa)
Noc_1745Radical SAM domain Fe-S oxidoreductase. (372 aa)
Noc_1747Conserved hypothetical protein. (901 aa)
Noc_1748Conserved hypothetical protein 374. (338 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (381 aa)
Noc_2011CBS domain containing protein. (286 aa)
Noc_2037Farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (296 aa)
Noc_2232UbiE/COQ5 methyltransferase. (232 aa)
ubiG3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (236 aa)
ubiEDemethylmenaquinone methyltransferase / 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (248 aa)
Noc_2344Protein of unknown function DUF1243. (202 aa)
ubiB2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (557 aa)
ubiXPhenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (205 aa)
Noc_2574Porphobilinogen synthase; Belongs to the ALAD family. (352 aa)
Noc_25802-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase / 2-octaprenyl-6-methoxyphenol hydroxylase. (409 aa)
Noc_25812-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase. (422 aa)
Noc_2749NUDIX hydrolase. (285 aa)
hemFCoproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (317 aa)
Noc_2849Rieske (2Fe-2S) protein. (118 aa)
hemEUroporphyrinogen decarboxylase HemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (357 aa)
Noc_3032Trans-hexaprenyltranstransferase; Belongs to the FPP/GGPP synthase family. (345 aa)
Your Current Organism:
Nitrosococcus oceani
NCBI taxonomy Id: 323261
Other names: N. oceani ATCC 19707, Nitrosococcus oceani ATCC 19707, Nitrosococcus oceani C-107, Nitrosococcus oceani NCIMB 11848, Nitrosococcus oceani str. ATCC 19707, Nitrosococcus oceani strain ATCC 19707
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