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| | fbp | D-fructose 1,6-bisphosphatase. (335 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (517 aa) |
| | Noc_0101 | Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (551 aa) |
| | Noc_0111 | 2-oxoglutarate dehydrogenase E1 component. (940 aa) |
| | Noc_0112 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (435 aa) |
| | Noc_0113 | Dihydrolipoamide dehydrogenase. (480 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa) |
| | Noc_0173 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (387 aa) |
| | Noc_0174 | Chorismate mutase. (361 aa) |
| | hisC1 | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa) |
| | Noc_0176 | Prephenate dehydrogenase. (286 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (444 aa) |
| | Noc_0244 | Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). (401 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (190 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa) |
| | Noc_0255 | Aminodeoxychorismate synthase, subunit I. (471 aa) |
| | Noc_0268 | Transketolase. (606 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (376 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (417 aa) |
| | Noc_0391 | Aldehyde dehydrogenase. (454 aa) |
| | Noc_0494 | Kinase-like protein. (371 aa) |
| | gcvT | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (371 aa) |
| | argH | Argininosuccinate lyase. (467 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (336 aa) |
| | Noc_0603 | Thioredoxin domain-containing protein. (287 aa) |
| | Noc_0712 | Prolyl aminopeptidase, Serine peptidase, MEROPS family S33; Belongs to the peptidase S33 family. (314 aa) |
| | sucC | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (957 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (490 aa) |
| | Noc_0826 | Short chain enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (672 aa) |
| | Noc_0827 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (434 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (426 aa) |
| | Noc_0864 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (657 aa) |
| | acyP | Acylphosphatase. (89 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (549 aa) |
| | gcvH | Glycine cleavage H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa) |
| | gcvPA | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (452 aa) |
| | Noc_0927 | Aspartate kinase; Belongs to the aspartokinase family. (413 aa) |
| | Noc_0965 | Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component-like enzyme. (467 aa) |
| | Noc_0983 | Ribose-phosphate pyrophosphokinase. (332 aa) |
| | Noc_0990 | Pyruvate kinase; Belongs to the pyruvate kinase family. (492 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (362 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (206 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa) |
| | Noc_1029 | Aspartate/glutamate/uridylate kinase. (480 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa) |
| | Noc_1138 | Aminotransferase. (395 aa) |
| | Noc_1254 | 2-oxo-acid dehydrogenase E1 component homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (891 aa) |
| | Noc_1255 | Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component-like enzyme. (447 aa) |
| | Noc_1256 | Dihydrolipoamide dehydrogenase. (472 aa) |
| | Noc_1266 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (602 aa) |
| | Noc_1267 | Hypothetical protein. (266 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (242 aa) |
| | Noc_1378 | Isocitrate dehydrogenase (NADP). (422 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (240 aa) |
| | Noc_1433 | Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component-like enzyme. (374 aa) |
| | Noc_1434 | Transketolase. (326 aa) |
| | pdhA | Pyruvate dehydrogenase (lipoamide); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (358 aa) |
| | Noc_1436 | Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (375 aa) |
| | Noc_1446 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (794 aa) |
| | Noc_1491 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (366 aa) |
| | Noc_1555 | Acyl-CoA dehydrogenase. (639 aa) |
| | Noc_1582 | Allosteric NADP-dependent malic enzyme; Phosphate acetyltransferase. (783 aa) |
| | Noc_1583 | Conserved hypothetical protein. (1170 aa) |
| | Noc_1603 | Glutamate synthase (NADH) small subunit. (480 aa) |
| | Noc_1604 | Glutamate synthase (NADH) large subunit. (1554 aa) |
| | Noc_1608 | NADPH-glutathione reductase; Maintains high levels of reduced glutathione. (452 aa) |
| | Noc_1622 | DAHP synthetase I/KDSA. (370 aa) |
| | fumC | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa) |
| | Noc_1697 | Carbohydrate kinase, FGGY. (426 aa) |
| | Noc_1705 | L-proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1044 aa) |
| | Noc_1710 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (513 aa) |
| | Noc_1711 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (409 aa) |
| | Noc_1712 | Arginase; Belongs to the arginase family. (309 aa) |
| | Noc_1719 | Phosphoglucomutase/phosphomannomutase. (563 aa) |
| | Noc_1733 | Short chain enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (744 aa) |
| | Noc_1734 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa) |
| | Noc_1735 | Acyl-CoA dehydrogenase-like protein. (781 aa) |
| | Noc_1736 | Conserved hypothetical protein. (728 aa) |
| | Noc_1788 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (907 aa) |
| | Noc_1888 | hydroxymethylglutaryl-CoA lyase. (306 aa) |
| | Noc_1889 | Enoyl-CoA hydratase/isomerase. (261 aa) |
| | Noc_1890 | Propionyl-CoA carboxylase. (535 aa) |
| | Noc_1891 | Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | Noc_1893 | Methylmalonyl-CoA mutase-like protein. (1139 aa) |
| | Noc_1957 | Orn/DAP/Arg decarboxylase 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (410 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (617 aa) |
| | argA | N-acetylglutamate synthase; ArgA; Belongs to the acetyltransferase family. ArgA subfamily. (460 aa) |
| | Noc_2017 | HAD-superfamily subfamily IB, PSPase-like protein. (242 aa) |
| | Noc_2046 | Zinc-containing alcohol dehydrogenase superfamily. (333 aa) |
| | Noc_2047 | Acetoacetyl-CoA synthase. (651 aa) |
| | Noc_2054 | Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (419 aa) |
| | tal-2 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (376 aa) |
| | Noc_2061 | 6-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (481 aa) |
| | zwf-2 | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa) |
| | Noc_2077 | 6-phosphogluconate dehydrogenase, NAD-binding protein. (285 aa) |
| | Noc_2103 | Aconitase; Belongs to the aconitase/IPM isomerase family. (850 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | Noc_2109 | Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component-like enzyme. (902 aa) |
| | Noc_2110 | Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa) |
| | pdhA-2 | Dehydrogenase, E1 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (339 aa) |
| | Noc_2123 | Protein of unknown function DUF815. (294 aa) |
| | Noc_2124 | Aminotransferase. (399 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (376 aa) |
| | Noc_2127 | Conserved hypothetical protein. (348 aa) |
| | Noc_2207 | 2-methylcitrate dehydratase. (483 aa) |
| | Noc_2208 | 2-methylcitrate synthase; Belongs to the citrate synthase family. (374 aa) |
| | prpB | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (294 aa) |
| | Noc_2280 | UDP-glucose pyrophosphorylase. (297 aa) |
| | Noc_2420 | NUDIX hydrolase. (184 aa) |
| | argD | Acetylornithine aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (304 aa) |
| | Noc_2453 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (360 aa) |
| | Noc_2454 | Homoserine dehydrogenase. (436 aa) |
| | Noc_2455 | Aminotransferase. (393 aa) |
| | Noc_2470 | Succinate dehydrogenase subunit B. (231 aa) |
| | Noc_2471 | Succinate dehydrogenase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (587 aa) |
| | Noc_2472 | Succinate dehydrogenase subunit D. (105 aa) |
| | Noc_2473 | Succinate dehydrogenase subunit C. (140 aa) |
| | Noc_2492 | Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (223 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (492 aa) |
| | Noc_2495 | Anthranilate synthase, component II. (193 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (271 aa) |
| | Noc_2504 | Phosphoserine phosphatase. (278 aa) |
| | Noc_2512 | NUDIX hydrolase; Belongs to the Nudix hydrolase family. (172 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | Noc_2519 | Acetolactate synthase, small subunit. (164 aa) |
| | Noc_2520 | Acetolactate synthase, large subunit. (582 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | gcvPB | Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (486 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (282 aa) |
| | hisZ | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (397 aa) |
| | Noc_2605 | Aldehyde dehydrogenase (acceptor). (494 aa) |
| | Noc_2606 | L-threonine aldolase. (346 aa) |
| | Noc_2607 | Acetylornithine deacetylase. (379 aa) |
| | Noc_2628 | Citrate synthase; Belongs to the citrate synthase family. (387 aa) |
| | Noc_2652 | L-glutamine synthetase. (469 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (509 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (220 aa) |
| | Noc_2707 | Aconitase. (660 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (408 aa) |
| | Noc_2717 | Fructose-6-phosphate phosphoketolase. (804 aa) |
| | hisC2 | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (360 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (433 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (213 aa) |
| | mdh | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (311 aa) |
| | Noc_2804 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | Noc_2805 | Pyruvate kinase; Belongs to the pyruvate kinase family. (483 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (392 aa) |
| | Noc_2807 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa) |
| | Noc_2808 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (271 aa) |
| | pfp | Pyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (421 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (405 aa) |
| | Noc_2916 | Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (519 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (369 aa) |
| | Noc_2957 | Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (510 aa) |
| | Noc_2978 | Glutamate dehydrogenase (NAD). (1594 aa) |
| | Noc_2994 | Phosphomannomutase. (468 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (278 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (249 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (132 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (104 aa) |
| | Noc_3057 | Histidine triad (HIT) protein. (115 aa) |
| | tatA | Twin-arginine translocation protein TatA/E; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (90 aa) |
| | tatB | Sec-independent protein translocase TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (96 aa) |
| | tatC | Sec-independent protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (250 aa) |
