(44 nodes) Phosphotyrosine residue binding network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXCOP00000016904	Cbl proto-oncogene, E3 ubiquitin protein ligase. (903 aa)
	ENSXCOP00000000002	SH2 domain-containing protein. (86 aa)
	ENSXCOP00000000034	Tyrosine-protein phosphatase domain-containing protein. (231 aa)
	Grb2	Growth factor receptor-bound protein 2b. (210 aa)
	Samsn1	SAM domain, SH3 domain and nuclear localisation signals 1a. (297 aa)
	Ptpn5	Uncharacterized protein. (156 aa)
	Shc3	PID domain-containing protein. (119 aa)
	Abl1	Protein kinase domain-containing protein. (223 aa)
	ENSXCOP00000003765	Tyrosine-protein phosphatase domain-containing protein. (139 aa)
	ENSXCOP00000004323	Low density lipoprotein receptor adaptor protein 1a. (143 aa)
	grap2	GRB2 related adaptor protein 2a. (288 aa)
	CRK	CRK proto-oncogene, adaptor protein. (315 aa)
	ENSXCOP00000006434	SH2 domain containing 3Ca. (581 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (299 aa)
	ENSXCOP00000007173	Uncharacterized protein. (731 aa)
	ENSXCOP00000007400	SH2 domain-containing protein. (83 aa)
	ENSXCOP00000007663	Suppressor of cytokine signaling 3. (218 aa)
	ENSXCOP00000008237	Uncharacterized protein. (408 aa)
	ENSXCOP00000008632	SH3-domain binding protein 2. (371 aa)
	ENSXCOP00000009300	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (662 aa)
	LOC114141391	Uncharacterized protein. (461 aa)
	ENSXCOP00000010067	Uncharacterized protein. (509 aa)
	Cblc	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (507 aa)
	ENSXCOP00000010793	BCAR3 adaptor protein, NSP family member. (756 aa)
	ENSXCOP00000010815	Src homology 2 domain containing E. (423 aa)
	Syk	Spleen tyrosine kinase. (271 aa)
	ENSXCOP00000011734	Protein kinase domain-containing protein. (143 aa)
	ENSXCOP00000012274	Uncharacterized protein. (100 aa)
	ENSXCOP00000013440	Src homology 2 domain containing transforming protein D, b. (361 aa)
	ENSXCOP00000014127	Suppressor of cytokine signaling 3a. (232 aa)
	Abl2	Tyrosine-protein kinase. (1177 aa)
	Ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (147 aa)
	ENSXCOP00000016600	Uncharacterized protein. (453 aa)
	ENSXCOP00000018819	Src homology 2 domain containing transforming protein D, a. (395 aa)
	SHF	Src homology 2 domain containing F. (438 aa)
	She	SH2 domain-containing protein. (451 aa)
	ENSXCOP00000026173	SHC (Src homology 2 domain containing) transforming protein 1. (459 aa)
	Ptpn6	Protein tyrosine phosphatase non-receptor type 6. (549 aa)
	CBL	Uncharacterized protein. (479 aa)
	ENSXCOP00000024891	UBA domain-containing protein. (130 aa)
	ENSXCOP00000024108	GRB2 related adaptor protein a. (239 aa)
	Pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (521 aa)
	ENSXCOP00000023527	SH2 domain-containing protein. (67 aa)
	ENSXCOP00000022345	RAS p21 protein activator (GTPase activating protein) 1a. (983 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abl1	Abl2	ENSXCOP00000003743	ENSXCOP00000014316	Protein kinase domain-containing protein.	Tyrosine-protein kinase.	0.912
Abl1	CBL	ENSXCOP00000003743	ENSXCOP00000024893	Protein kinase domain-containing protein.	Uncharacterized protein.	0.492
Abl1	CRK	ENSXCOP00000003743	ENSXCOP00000005850	Protein kinase domain-containing protein.	CRK proto-oncogene, adaptor protein.	0.970
Abl1	Cblc	ENSXCOP00000003743	ENSXCOP00000010328	Protein kinase domain-containing protein.	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.492
Abl1	ENSXCOP00000007400	ENSXCOP00000003743	ENSXCOP00000007400	Protein kinase domain-containing protein.	SH2 domain-containing protein.	0.400
Abl1	ENSXCOP00000016904	ENSXCOP00000003743	ENSXCOP00000016904	Protein kinase domain-containing protein.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.492
Abl1	ENSXCOP00000024108	ENSXCOP00000003743	ENSXCOP00000024108	Protein kinase domain-containing protein.	GRB2 related adaptor protein a.	0.400
Abl1	ENSXCOP00000024891	ENSXCOP00000003743	ENSXCOP00000024891	Protein kinase domain-containing protein.	UBA domain-containing protein.	0.492
Abl1	Grb2	ENSXCOP00000003743	ENSXCOP00000000623	Protein kinase domain-containing protein.	Growth factor receptor-bound protein 2b.	0.727
Abl1	crkl	ENSXCOP00000003743	ENSXCOP00000006931	Protein kinase domain-containing protein.	V-crk avian sarcoma virus CT10 oncogene homolog-like.	0.970
Abl1	grap2	ENSXCOP00000003743	ENSXCOP00000005470	Protein kinase domain-containing protein.	GRB2 related adaptor protein 2a.	0.400
Abl2	Abl1	ENSXCOP00000014316	ENSXCOP00000003743	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.912
Abl2	CBL	ENSXCOP00000014316	ENSXCOP00000024893	Tyrosine-protein kinase.	Uncharacterized protein.	0.492
Abl2	CRK	ENSXCOP00000014316	ENSXCOP00000005850	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.970
Abl2	Cblc	ENSXCOP00000014316	ENSXCOP00000010328	Tyrosine-protein kinase.	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.492
Abl2	ENSXCOP00000007400	ENSXCOP00000014316	ENSXCOP00000007400	Tyrosine-protein kinase.	SH2 domain-containing protein.	0.400
Abl2	ENSXCOP00000016904	ENSXCOP00000014316	ENSXCOP00000016904	Tyrosine-protein kinase.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.492
Abl2	ENSXCOP00000024108	ENSXCOP00000014316	ENSXCOP00000024108	Tyrosine-protein kinase.	GRB2 related adaptor protein a.	0.400
Abl2	ENSXCOP00000024891	ENSXCOP00000014316	ENSXCOP00000024891	Tyrosine-protein kinase.	UBA domain-containing protein.	0.492
Abl2	Grb2	ENSXCOP00000014316	ENSXCOP00000000623	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2b.	0.727