(40 nodes) Neural tube closure network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXCOP00000026419	Uncharacterized protein. (95 aa)
	ENSXCOP00000002133	Dishevelled segment polarity protein 2. (736 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (661 aa)
	Abl1	Protein kinase domain-containing protein. (223 aa)
	ENSXCOP00000003757	Phosphatase and actin regulator. (121 aa)
	Prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (333 aa)
	ENSXCOP00000004757	Phosphatase and actin regulator. (525 aa)
	ENSXCOP00000005549	DEAF1 transcription factor. (524 aa)
	Mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (367 aa)
	ENSXCOP00000006227	HECT domain containing 1. (1967 aa)
	Hectd1	Uncharacterized protein. (164 aa)
	ENSXCOP00000007004	Uncharacterized protein. (245 aa)
	ENSXCOP00000008676	Bromo domain-containing protein. (1081 aa)
	ENSXCOP00000009599	Glomulin, FKBP associated protein a. (579 aa)
	ENSXCOP00000011851	Phosphatase and actin regulator. (757 aa)
	Mks1	MKS transition zone complex subunit 1. (512 aa)
	ENSXCOP00000012982	Transforming growth factor beta; Belongs to the TGF-beta family. (389 aa)
	Abl2	Tyrosine-protein kinase. (1177 aa)
	ENSXCOP00000014635	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (933 aa)
	ENSXCOP00000016743	Uncharacterized protein. (266 aa)
	ENSXCOP00000016823	DIX domain-containing protein. (55 aa)
	ENSXCOP00000016824	Uncharacterized protein. (448 aa)
	ENSXCOP00000017018	FZ domain-containing protein. (137 aa)
	ENSXCOP00000018976	Dishevelled segment polarity protein 1a. (672 aa)
	Dvl1	DIX domain-containing protein. (82 aa)
	ENSXCOP00000019260	TSC complex subunit 2. (1718 aa)
	ENSXCOP00000019334	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (339 aa)
	ENSXCOP00000019948	Phosphatase and actin regulator. (587 aa)
	LOC114146401	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	ENSXCOP00000020644	Spalt-like transcription factor 4. (1025 aa)
	Cthrc1	Collagen triple helix repeat containing 1b. (113 aa)
	ENSXCOP00000021691	Cobl domain-containing protein. (845 aa)
	ENSXCOP00000027087	Lysine (K)-specific demethylase 6A, like. (1373 aa)
	ENSXCOP00000026475	Serine peptidase inhibitor, Kunitz type 1 b. (508 aa)
	ENSXCOP00000026438	Uncharacterized protein. (732 aa)
	ccdc85b	Coiled-coil domain containing 85B. (200 aa)
	ENSXCOP00000023215	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (196 aa)
	tmed2	Transmembrane p24 trafficking protein 2. (201 aa)
	ENSXCOP00000024371	Bardet-Biedl syndrome 4. (520 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abl1	Abl2	ENSXCOP00000003743	ENSXCOP00000014316	Protein kinase domain-containing protein.	Tyrosine-protein kinase.	0.912
Abl2	Abl1	ENSXCOP00000014316	ENSXCOP00000003743	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.912
Dvl1	ENSXCOP00000016824	ENSXCOP00000018986	ENSXCOP00000016824	DIX domain-containing protein.	Uncharacterized protein.	0.908
Dvl1	ENSXCOP00000017018	ENSXCOP00000018986	ENSXCOP00000017018	DIX domain-containing protein.	FZ domain-containing protein.	0.470
Dvl1	sfrp2	ENSXCOP00000018986	ENSXCOP00000002513	DIX domain-containing protein.	Secreted frizzled-related protein 2.	0.470
ENSXCOP00000002133	ENSXCOP00000017018	ENSXCOP00000002133	ENSXCOP00000017018	Dishevelled segment polarity protein 2.	FZ domain-containing protein.	0.470
ENSXCOP00000002133	sfrp2	ENSXCOP00000002133	ENSXCOP00000002513	Dishevelled segment polarity protein 2.	Secreted frizzled-related protein 2.	0.470
ENSXCOP00000006227	Hectd1	ENSXCOP00000006227	ENSXCOP00000006962	HECT domain containing 1.	Uncharacterized protein.	0.917
ENSXCOP00000007004	ENSXCOP00000019260	ENSXCOP00000007004	ENSXCOP00000019260	Uncharacterized protein.	TSC complex subunit 2.	0.998
ENSXCOP00000007004	ENSXCOP00000027087	ENSXCOP00000007004	ENSXCOP00000027087	Uncharacterized protein.	Lysine (K)-specific demethylase 6A, like.	0.735
ENSXCOP00000008676	ENSXCOP00000026438	ENSXCOP00000008676	ENSXCOP00000026438	Bromo domain-containing protein.	Uncharacterized protein.	0.535
ENSXCOP00000012982	ENSXCOP00000023215	ENSXCOP00000012982	ENSXCOP00000023215	Transforming growth factor beta; Belongs to the TGF-beta family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.685
ENSXCOP00000014635	Mthfd1l	ENSXCOP00000014635	ENSXCOP00000005682	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.901
ENSXCOP00000014635	mthfr	ENSXCOP00000014635	ENSXCOP00000003360	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.969
ENSXCOP00000016823	ENSXCOP00000017018	ENSXCOP00000016823	ENSXCOP00000017018	DIX domain-containing protein.	FZ domain-containing protein.	0.470
ENSXCOP00000016823	sfrp2	ENSXCOP00000016823	ENSXCOP00000002513	DIX domain-containing protein.	Secreted frizzled-related protein 2.	0.470
ENSXCOP00000016824	Dvl1	ENSXCOP00000016824	ENSXCOP00000018986	Uncharacterized protein.	DIX domain-containing protein.	0.908
ENSXCOP00000016824	ENSXCOP00000017018	ENSXCOP00000016824	ENSXCOP00000017018	Uncharacterized protein.	FZ domain-containing protein.	0.470
ENSXCOP00000016824	sfrp2	ENSXCOP00000016824	ENSXCOP00000002513	Uncharacterized protein.	Secreted frizzled-related protein 2.	0.470
ENSXCOP00000017018	Dvl1	ENSXCOP00000017018	ENSXCOP00000018986	FZ domain-containing protein.	DIX domain-containing protein.	0.470