(10 nodes) Negative regulation of transcription elongation from RNA polymerase II promoter network (Xiphophorus couchianus)

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Your Input:
	ENSXCOP00000024199	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (951 aa)
	ENSXCOP00000016765	Ring finger protein 168. (353 aa)
	Nelfa	Negative elongation factor complex member A. (525 aa)
	nelfb	Negative elongation factor complex member B. (585 aa)
	sirt6	Sirtuin 6. (351 aa)
	ENSXCOP00000006971	E2f-associated phosphoprotein. (265 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (467 aa)
	ENSXCOP00000026128	Negative elongation factor complex member E. (330 aa)
	Nelfcd	Negative elongation factor complex member C/D. (608 aa)
	ENSXCOP00000017440	SPT5 homolog, DSIF elongation factor subunit. (342 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXCOP00000016765	RNF8	ENSXCOP00000016765	ENSXCOP00000002835	Ring finger protein 168.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.823
ENSXCOP00000017440	ENSXCOP00000026128	ENSXCOP00000017440	ENSXCOP00000026128	SPT5 homolog, DSIF elongation factor subunit.	Negative elongation factor complex member E.	0.934
ENSXCOP00000017440	Nelfa	ENSXCOP00000017440	ENSXCOP00000011973	SPT5 homolog, DSIF elongation factor subunit.	Negative elongation factor complex member A.	0.973
ENSXCOP00000017440	Nelfcd	ENSXCOP00000017440	ENSXCOP00000024817	SPT5 homolog, DSIF elongation factor subunit.	Negative elongation factor complex member C/D.	0.959
ENSXCOP00000017440	nelfb	ENSXCOP00000017440	ENSXCOP00000011467	SPT5 homolog, DSIF elongation factor subunit.	Negative elongation factor complex member B.	0.975
ENSXCOP00000026128	ENSXCOP00000017440	ENSXCOP00000026128	ENSXCOP00000017440	Negative elongation factor complex member E.	SPT5 homolog, DSIF elongation factor subunit.	0.934
ENSXCOP00000026128	Nelfa	ENSXCOP00000026128	ENSXCOP00000011973	Negative elongation factor complex member E.	Negative elongation factor complex member A.	0.988
ENSXCOP00000026128	Nelfcd	ENSXCOP00000026128	ENSXCOP00000024817	Negative elongation factor complex member E.	Negative elongation factor complex member C/D.	0.988
ENSXCOP00000026128	nelfb	ENSXCOP00000026128	ENSXCOP00000011467	Negative elongation factor complex member E.	Negative elongation factor complex member B.	0.988
Nelfa	ENSXCOP00000017440	ENSXCOP00000011973	ENSXCOP00000017440	Negative elongation factor complex member A.	SPT5 homolog, DSIF elongation factor subunit.	0.973
Nelfa	ENSXCOP00000026128	ENSXCOP00000011973	ENSXCOP00000026128	Negative elongation factor complex member A.	Negative elongation factor complex member E.	0.988
Nelfa	Nelfcd	ENSXCOP00000011973	ENSXCOP00000024817	Negative elongation factor complex member A.	Negative elongation factor complex member C/D.	0.992
Nelfa	nelfb	ENSXCOP00000011973	ENSXCOP00000011467	Negative elongation factor complex member A.	Negative elongation factor complex member B.	0.991
Nelfcd	ENSXCOP00000017440	ENSXCOP00000024817	ENSXCOP00000017440	Negative elongation factor complex member C/D.	SPT5 homolog, DSIF elongation factor subunit.	0.959
Nelfcd	ENSXCOP00000026128	ENSXCOP00000024817	ENSXCOP00000026128	Negative elongation factor complex member C/D.	Negative elongation factor complex member E.	0.988
Nelfcd	Nelfa	ENSXCOP00000024817	ENSXCOP00000011973	Negative elongation factor complex member C/D.	Negative elongation factor complex member A.	0.992
Nelfcd	nelfb	ENSXCOP00000024817	ENSXCOP00000011467	Negative elongation factor complex member C/D.	Negative elongation factor complex member B.	0.991
RNF8	ENSXCOP00000016765	ENSXCOP00000002835	ENSXCOP00000016765	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Ring finger protein 168.	0.823
nelfb	ENSXCOP00000017440	ENSXCOP00000011467	ENSXCOP00000017440	Negative elongation factor complex member B.	SPT5 homolog, DSIF elongation factor subunit.	0.975
nelfb	ENSXCOP00000026128	ENSXCOP00000011467	ENSXCOP00000026128	Negative elongation factor complex member B.	Negative elongation factor complex member E.	0.988