(103 nodes) Tyrosine-protein kinase, active site network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXCOP00000009826	Eph receptor B3a. (927 aa)
	ENSXCOP00000009900	Tyrosine-protein kinase receptor. (641 aa)
	Blk	Tyrosine-protein kinase. (404 aa)
	ENSXCOP00000009950	Tyrosine-protein kinase. (591 aa)
	ENSXCOP00000009957	TXK tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (235 aa)
	ENSXCOP00000010215	Tyrosine kinase, non-receptor, 2b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	ENSXCOP00000010269	Tyrosine-protein kinase. (463 aa)
	ENSXCOP00000010730	Eph receptor A4b. (909 aa)
	ENSXCOP00000010754	Uncharacterized protein. (929 aa)
	Ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (922 aa)
	ENSXCOP00000010958	Tyrosine-protein kinase. (1075 aa)
	Kit	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (835 aa)
	Lmtk2	Lemur tyrosine kinase 2. (1468 aa)
	ENSXCOP00000011734	Protein kinase domain-containing protein. (143 aa)
	Plk4	Polo-like kinase 4 (Drosophila). (863 aa)
	ENSXCOP00000012050	Protein kinase domain-containing protein. (374 aa)
	ENSXCOP00000012089	Discoidin domain receptor tyrosine kinase 2a. (820 aa)
	ENSXCOP00000012341	Uncharacterized protein. (951 aa)
	ENSXCOP00000012609	Eph receptor A7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (389 aa)
	ENSXCOP00000012623	Tyrosine-protein kinase. (1119 aa)
	Flt1	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1206 aa)
	AXL	AXL receptor tyrosine kinase. (826 aa)
	ENSXCOP00000013295	Discoidin domain receptor tyrosine kinase 2b. (842 aa)
	ENSXCOP00000013415	Protein kinase domain-containing protein. (262 aa)
	ENSXCOP00000013466	Protein kinase domain-containing protein. (258 aa)
	ENSXCOP00000014244	Apoptosis-associated tyrosine kinase a. (1451 aa)
	Abl2	Tyrosine-protein kinase. (1177 aa)
	ENSXCOP00000014956	Protein kinase domain-containing protein. (706 aa)
	fes	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (828 aa)
	ENSXCOP00000015386	C-mer proto-oncogene tyrosine kinase a. (936 aa)
	YES1	Tyrosine-protein kinase. (548 aa)
	ENSXCOP00000016721	Tyrosine-protein kinase receptor. (986 aa)
	CSK	Tyrosine-protein kinase. (394 aa)
	ENSXCOP00000017449	Eph receptor B4b. (933 aa)
	lck	Tyrosine-protein kinase. (500 aa)
	ENSXCOP00000017571	Tyrosine-protein kinase receptor. (517 aa)
	ENSXCOP00000018121	KIT proto-oncogene, receptor tyrosine kinase b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (920 aa)
	ENSXCOP00000018489	Receptor protein-tyrosine kinase. (1093 aa)
	ENSXCOP00000018652	Tyrosine-protein kinase. (482 aa)
	ENSXCOP00000019411	Uncharacterized protein. (425 aa)
	ENSXCOP00000020395	Protein kinase domain-containing protein. (197 aa)
	Fgfr1	Protein kinase domain-containing protein. (301 aa)
	Ephb2	Eph receptor B2b. (975 aa)
	ENSXCOP00000021048	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1171 aa)
	ENSXCOP00000021618	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (970 aa)
	Egfr	Receptor protein-tyrosine kinase. (1206 aa)
	ENSXCOP00000021820	Fibroblast growth factor receptor. (695 aa)
	Tp53rk	TP53 regulating kinase. (214 aa)
	ENSXCOP00000005103	Fibroblast growth factor receptor. (761 aa)
	ENSXCOP00000005612	Tyrosine-protein kinase receptor. (588 aa)
	Fgfr3	Fibroblast growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (382 aa)
	Epha4	Eph receptor A4, like. (928 aa)
	ENSXCOP00000021901	Tyrosine-protein kinase. (543 aa)
	ENSXCOP00000021910	Tyrosine-protein kinase. (445 aa)
	tyk2	Tyrosine-protein kinase. (1155 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	Btk	Tyrosine-protein kinase. (620 aa)
	ENSXCOP00000022519	Tyrosine-protein kinase. (499 aa)
	ENSXCOP00000024141	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
	ENSXCOP00000024152	Uncharacterized protein. (941 aa)
	ENSXCOP00000024244	Tyrosine-protein kinase receptor. (761 aa)
	ENSXCOP00000025041	Discoidin domain receptor family, member 2, like. (790 aa)
	Insr	Tyrosine-protein kinase receptor. (1334 aa)
	ENSXCOP00000025934	Receptor protein-tyrosine kinase. (712 aa)
	ENSXCOP00000026618	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (944 aa)
	ENSXCOP00000026983	Tyrosine-protein kinase. (463 aa)
	ENSXCOP00000027158	Tyrosine-protein kinase receptor. (1403 aa)
	ENSXCOP00000027981	Pseudopodium-enriched atypical kinase 1. (1777 aa)
	ENSXCOP00000022370	Eph receptor B2a. (941 aa)
	Met	Protein kinase domain-containing protein. (237 aa)
	LOC114149322	Tyrosine-protein kinase. (1124 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (863 aa)
	ENSXCOP00000006686	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (883 aa)
	Hck	Tyrosine-protein kinase. (518 aa)
	LOC114140865	Tyrosine-protein kinase. (527 aa)
	matk	Tyrosine-protein kinase. (459 aa)
	ENSXCOP00000001154	Receptor protein-tyrosine kinase. (610 aa)
	Epha3	Eph receptor A3. (819 aa)
	Pdgfra	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. (783 aa)
	ENSXCOP00000002272	Tyrosine-protein kinase receptor. (578 aa)
	ENSXCOP00000002457	EPH receptor B1. (927 aa)
	Epha2	Eph receptor A2 b. (906 aa)
	Tnk1	Tyrosine kinase, non-receptor, 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (740 aa)
	PRAG1	PEAK1 related, kinase-activating pseudokinase 1. (1143 aa)
	Abl1	Protein kinase domain-containing protein. (223 aa)
	Pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1037 aa)
	LOC114139479	Colony stimulating factor 1 receptor, a. (994 aa)
	ENSXCOP00000004382	Apoptosis-associated tyrosine kinase b. (1181 aa)
	ENSXCOP00000004420	Uncharacterized protein. (909 aa)
	jak3	Tyrosine-protein kinase. (1104 aa)
	ENSXCOP00000004744	Protein kinase domain-containing protein. (248 aa)
	ENSXCOP00000006722	Uncharacterized protein. (838 aa)
	NTRK3	Tyrosine-protein kinase receptor. (803 aa)
	ENSXCOP00000007305	Tyrosine-protein kinase. (546 aa)
	ENSXCOP00000007832	Receptor like tyrosine kinase. (540 aa)
	Ret	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1087 aa)
	ENSXCOP00000007973	Si:ch211-167j9.5. (221 aa)
	LOC114158825	Tyrosine-protein kinase. (521 aa)
	ENSXCOP00000008405	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (377 aa)
	ENSXCOP00000008918	Fibroblast growth factor receptor. (720 aa)
	ENSXCOP00000009063	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (517 aa)
	Ephb4	Eph receptor B4a. (952 aa)
	ENSXCOP00000009583	NIMA-related kinase 10. (973 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abl1	Abl2	ENSXCOP00000003743	ENSXCOP00000014316	Protein kinase domain-containing protein.	Tyrosine-protein kinase.	0.912
Abl2	Abl1	ENSXCOP00000014316	ENSXCOP00000003743	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.912
Blk	CSK	ENSXCOP00000009930	ENSXCOP00000016756	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.581
Blk	ENSXCOP00000001154	ENSXCOP00000009930	ENSXCOP00000001154	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.415
Blk	ENSXCOP00000006686	ENSXCOP00000009930	ENSXCOP00000006686	Tyrosine-protein kinase.	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.542
Blk	ENSXCOP00000007305	ENSXCOP00000009930	ENSXCOP00000007305	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.424
Blk	ENSXCOP00000009900	ENSXCOP00000009930	ENSXCOP00000009900	Tyrosine-protein kinase.	Tyrosine-protein kinase receptor.	0.401
Blk	ENSXCOP00000011734	ENSXCOP00000009930	ENSXCOP00000011734	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.557
Blk	ENSXCOP00000012050	ENSXCOP00000009930	ENSXCOP00000012050	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.422
Blk	ENSXCOP00000013415	ENSXCOP00000009930	ENSXCOP00000013415	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.541
Blk	ENSXCOP00000013466	ENSXCOP00000009930	ENSXCOP00000013466	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.538
Blk	ENSXCOP00000018652	ENSXCOP00000009930	ENSXCOP00000018652	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.427
Blk	ENSXCOP00000021618	ENSXCOP00000009930	ENSXCOP00000021618	Tyrosine-protein kinase.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.542
Blk	ENSXCOP00000021910	ENSXCOP00000009930	ENSXCOP00000021910	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.664
Blk	ENSXCOP00000022519	ENSXCOP00000009930	ENSXCOP00000022519	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.432
Blk	ENSXCOP00000026618	ENSXCOP00000009930	ENSXCOP00000026618	Tyrosine-protein kinase.	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.542
Blk	ENSXCOP00000026983	ENSXCOP00000009930	ENSXCOP00000026983	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.422
Blk	Met	ENSXCOP00000009930	ENSXCOP00000006308	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.533
Blk	Pdgfrb	ENSXCOP00000009930	ENSXCOP00000004128	Tyrosine-protein kinase.	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.538
Blk	Ret	ENSXCOP00000009930	ENSXCOP00000007884	Tyrosine-protein kinase.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.414