(120 nodes) Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template network (Xiphophorus couchianus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC114138536	BTB domain-containing protein. (531 aa)
	ENSXCOP00000002001	REV3 like, DNA directed polymerase zeta catalytic subunit. (2197 aa)
	Rev3l	DNA_pol_B domain-containing protein. (389 aa)
	rpa2	Replication protein A2. (278 aa)
	ENSXCOP00000000673	B30.2/SPRY domain-containing protein. (423 aa)
	ENSXCOP00000000478	B30.2/SPRY domain-containing protein. (148 aa)
	ENSXCOP00000000466	B30.2/SPRY domain-containing protein. (234 aa)
	Polh	Polymerase (DNA directed), eta. (696 aa)
	ENSXCOP00000000379	Uncharacterized protein. (236 aa)
	ENSXCOP00000000359	RING-type domain-containing protein. (85 aa)
	ENSXCOP00000000190	Uncharacterized protein. (373 aa)
	LOC114146163	Uncharacterized protein. (535 aa)
	ENSXCOP00000027383	KxDL motif containing 1. (193 aa)
	ENSXCOP00000027069	CHY-type domain-containing protein. (215 aa)
	ENSXCOP00000026742	RING-type domain-containing protein. (93 aa)
	ENSXCOP00000026732	RING-type domain-containing protein. (385 aa)
	ENSXCOP00000026726	Uncharacterized protein. (269 aa)
	ENSXCOP00000026713	B30.2/SPRY domain-containing protein. (183 aa)
	ENSXCOP00000026699	RING-type domain-containing protein. (118 aa)
	ENSXCOP00000026695	Uncharacterized protein. (204 aa)
	ENSXCOP00000026694	RING-type domain-containing protein. (108 aa)
	ENSXCOP00000026693	Uncharacterized protein. (387 aa)
	ENSXCOP00000026621	Polymerase (DNA-directed), delta 3, accessory subunit. (412 aa)
	ENSXCOP00000025464	SprT-like N-terminal domain. (443 aa)
	ENSXCOP00000025145	REV1 DNA directed polymerase. (813 aa)
	RCBTB1	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	ENSXCOP00000024658	ATPase family AAA domain containing 5a. (1287 aa)
	Pold1	DNA polymerase. (1089 aa)
	ENSXCOP00000023325	Tripartite motif containing 25, like. (547 aa)
	LOC114149001	Ubiquitin-like domain-containing protein. (77 aa)
	ENSXCOP00000023007	RING-type domain-containing protein. (205 aa)
	Pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2225 aa)
	Vcp	Valosin containing protein; Belongs to the AAA ATPase family. (761 aa)
	Polk	Polymerase (DNA directed) kappa. (366 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	ENSXCOP00000021606	RING-type domain-containing protein. (74 aa)
	ENSXCOP00000021513	Uncharacterized protein. (552 aa)
	ENSXCOP00000021346	Uncharacterized protein. (436 aa)
	ENSXCOP00000021172	Uncharacterized protein. (236 aa)
	ENSXCOP00000021073	PCNA clamp associated factor. (114 aa)
	ENSXCOP00000021026	Ubiquitin specific peptidase 43b; Belongs to the peptidase C19 family. (1142 aa)
	Pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
	ENSXCOP00000020726	Uncharacterized protein. (313 aa)
	SPATA5	Spermatogenesis associated 5; Belongs to the AAA ATPase family. (684 aa)
	ENSXCOP00000020569	RING-type domain-containing protein. (138 aa)
	ENSXCOP00000019807	Uncharacterized protein. (571 aa)
	ENSXCOP00000009899	B30.2/SPRY domain-containing protein. (221 aa)
	ENSXCOP00000009940	Uncharacterized protein. (333 aa)
	ENSXCOP00000010010	Uncharacterized protein. (281 aa)
	ENSXCOP00000010035	Uncharacterized protein. (485 aa)
	ENSXCOP00000010040	B30.2/SPRY domain-containing protein. (336 aa)
	ENSXCOP00000010347	B30.2/SPRY domain-containing protein. (184 aa)
	ENSXCOP00000010628	Uncharacterized protein. (509 aa)
	ENSXCOP00000011016	B30.2/SPRY domain-containing protein. (262 aa)
	ENSXCOP00000011018	Pyrin domain-containing protein. (98 aa)
	ENSXCOP00000011173	B30.2/SPRY domain-containing protein. (271 aa)
	ENSXCOP00000011652	Uncharacterized protein. (543 aa)
	ENSXCOP00000011761	Uncharacterized protein. (316 aa)
	ENSXCOP00000011868	Ig-like domain-containing protein. (140 aa)
	ENSXCOP00000013093	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (554 aa)
	Rfc3	Replication factor C (activator 1) 3. (333 aa)
	ENSXCOP00000013308	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (589 aa)
	ENSXCOP00000013866	RING-type domain-containing protein. (185 aa)
	ENSXCOP00000014018	RING-type domain-containing protein. (100 aa)
	ENSXCOP00000014165	SCY domain-containing protein. (122 aa)
	Pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (145 aa)
	Pold4	Uncharacterized protein. (72 aa)
	ENSXCOP00000014960	Uncharacterized protein. (564 aa)
	Usp10	Ubiquitin specific peptidase 10; Belongs to the peptidase C19 family. (912 aa)
	ENSXCOP00000017110	Uncharacterized protein. (230 aa)
	ENSXCOP00000017171	Uncharacterized protein. (258 aa)
	ENSXCOP00000017306	Uncharacterized protein. (275 aa)
	ENSXCOP00000017359	Uncharacterized protein. (557 aa)
	ENSXCOP00000017362	Uncharacterized protein. (244 aa)
	ENSXCOP00000017365	B30.2/SPRY domain-containing protein. (224 aa)
	ENSXCOP00000017367	RING-type domain-containing protein. (73 aa)
	ENSXCOP00000017368	PRY domain-containing protein. (271 aa)
	ENSXCOP00000018217	RFC1 domain-containing protein. (149 aa)
	ENSXCOP00000018218	BRCT domain-containing protein. (450 aa)
	ENSXCOP00000018359	Uncharacterized protein. (556 aa)
	ENSXCOP00000018607	Uncharacterized protein. (234 aa)
	ENSXCOP00000019342	Zgc:136908; Belongs to the AAA ATPase family. (725 aa)
	ENSXCOP00000009819	B30.2/SPRY domain-containing protein. (230 aa)
	ENSXCOP00000009816	Uncharacterized protein. (236 aa)
	ENSXCOP00000009769	B30.2/SPRY domain-containing protein. (281 aa)
	ENSXCOP00000009234	Uncharacterized protein. (253 aa)
	ENSXCOP00000008949	B30.2/SPRY domain-containing protein. (202 aa)
	ENSXCOP00000008941	RING-type domain-containing protein. (312 aa)
	ENSXCOP00000008919	Uncharacterized protein. (229 aa)
	ENSXCOP00000008821	B box-type domain-containing protein. (270 aa)
	ENSXCOP00000008552	B30.2/SPRY domain-containing protein. (198 aa)
	ENSXCOP00000008535	Bloodthirsty-related gene family, member 12. (561 aa)
	ENSXCOP00000008232	Si:dkey-46i9.6. (543 aa)
	ENSXCOP00000008064	B30.2/SPRY domain-containing protein. (210 aa)
	ENSXCOP00000008061	B30.2/SPRY domain-containing protein. (190 aa)
	ENSXCOP00000008053	Uncharacterized protein. (429 aa)
	LOC114133261	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	Rfc4	Replication factor C (activator 1) 4. (325 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	ENSXCOP00000007103	Uncharacterized protein. (544 aa)
	ENSXCOP00000007009	B30.2/SPRY domain-containing protein. (211 aa)
	ENSXCOP00000006804	RING-type domain-containing protein. (96 aa)
	ENSXCOP00000006801	RING-type domain-containing protein. (128 aa)
	LOC114150032	Uncharacterized protein. (556 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	ENSXCOP00000005823	Uncharacterized protein. (366 aa)
	ENSXCOP00000005707	Uncharacterized protein. (383 aa)
	ENSXCOP00000004968	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (523 aa)
	LOC114138068	Ribosomal protein S27a. (156 aa)
	Nploc4	NPL4 homolog, ubiquitin recognition factor. (505 aa)
	Rpa3	Replication protein A3. (120 aa)
	ENSXCOP00000003814	Methionine sulfoxide reductase B1b. (403 aa)
	ENSXCOP00000003795	RING-type domain-containing protein. (326 aa)
	Mad2l2	Mitotic arrest deficient 2 like 2. (200 aa)
	ENSXCOP00000003089	Uncharacterized protein. (541 aa)
	ENSXCOP00000003085	Uncharacterized protein. (413 aa)
	ENSXCOP00000002686	Ubiquitin recognition factor in ER associated degradation 1. (283 aa)
	ENSXCOP00000002611	RING-type domain-containing protein. (182 aa)
	USP31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1276 aa)
	ENSXCOP00000002448	Uncharacterized protein. (194 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXCOP00000002001	ENSXCOP00000003814	ENSXCOP00000002001	ENSXCOP00000003814	REV3 like, DNA directed polymerase zeta catalytic subunit.	Methionine sulfoxide reductase B1b.	0.621
ENSXCOP00000002001	ENSXCOP00000004968	ENSXCOP00000002001	ENSXCOP00000004968	REV3 like, DNA directed polymerase zeta catalytic subunit.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.945
ENSXCOP00000002001	ENSXCOP00000013093	ENSXCOP00000002001	ENSXCOP00000013093	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.638
ENSXCOP00000002001	ENSXCOP00000013308	ENSXCOP00000002001	ENSXCOP00000013308	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.638
ENSXCOP00000002001	ENSXCOP00000014165	ENSXCOP00000002001	ENSXCOP00000014165	REV3 like, DNA directed polymerase zeta catalytic subunit.	SCY domain-containing protein.	0.779
ENSXCOP00000002001	ENSXCOP00000018217	ENSXCOP00000002001	ENSXCOP00000018217	REV3 like, DNA directed polymerase zeta catalytic subunit.	RFC1 domain-containing protein.	0.672
ENSXCOP00000002001	ENSXCOP00000018218	ENSXCOP00000002001	ENSXCOP00000018218	REV3 like, DNA directed polymerase zeta catalytic subunit.	BRCT domain-containing protein.	0.672
ENSXCOP00000002001	ENSXCOP00000024658	ENSXCOP00000002001	ENSXCOP00000024658	REV3 like, DNA directed polymerase zeta catalytic subunit.	ATPase family AAA domain containing 5a.	0.665
ENSXCOP00000002001	ENSXCOP00000025145	ENSXCOP00000002001	ENSXCOP00000025145	REV3 like, DNA directed polymerase zeta catalytic subunit.	REV1 DNA directed polymerase.	0.969
ENSXCOP00000002001	ENSXCOP00000025464	ENSXCOP00000002001	ENSXCOP00000025464	REV3 like, DNA directed polymerase zeta catalytic subunit.	SprT-like N-terminal domain.	0.420
ENSXCOP00000002001	ENSXCOP00000026621	ENSXCOP00000002001	ENSXCOP00000026621	REV3 like, DNA directed polymerase zeta catalytic subunit.	Polymerase (DNA-directed), delta 3, accessory subunit.	0.780
ENSXCOP00000002001	LOC114149001	ENSXCOP00000002001	ENSXCOP00000023106	REV3 like, DNA directed polymerase zeta catalytic subunit.	Ubiquitin-like domain-containing protein.	0.532
ENSXCOP00000002001	Mad2l2	ENSXCOP00000002001	ENSXCOP00000003563	REV3 like, DNA directed polymerase zeta catalytic subunit.	Mitotic arrest deficient 2 like 2.	0.970
ENSXCOP00000002001	Pold1	ENSXCOP00000002001	ENSXCOP00000024299	REV3 like, DNA directed polymerase zeta catalytic subunit.	DNA polymerase.	0.695
ENSXCOP00000002001	Pold2	ENSXCOP00000002001	ENSXCOP00000020803	REV3 like, DNA directed polymerase zeta catalytic subunit.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.976
ENSXCOP00000002001	Pold4	ENSXCOP00000002001	ENSXCOP00000014945	REV3 like, DNA directed polymerase zeta catalytic subunit.	Uncharacterized protein.	0.790
ENSXCOP00000002001	Pole	ENSXCOP00000002001	ENSXCOP00000022773	REV3 like, DNA directed polymerase zeta catalytic subunit.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.783
ENSXCOP00000002001	Pole4	ENSXCOP00000002001	ENSXCOP00000014172	REV3 like, DNA directed polymerase zeta catalytic subunit.	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.779
ENSXCOP00000002001	Polh	ENSXCOP00000002001	ENSXCOP00000000415	REV3 like, DNA directed polymerase zeta catalytic subunit.	Polymerase (DNA directed), eta.	0.943
ENSXCOP00000002001	Polk	ENSXCOP00000002001	ENSXCOP00000022457	REV3 like, DNA directed polymerase zeta catalytic subunit.	Polymerase (DNA directed) kappa.	0.906