(28 nodes) Translesion Synthesis by POLH network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Rfc4	Replication factor C (activator 1) 4. (325 aa)
	ENSXCOP00000027383	KxDL motif containing 1. (193 aa)
	ENSXCOP00000027069	CHY-type domain-containing protein. (215 aa)
	ENSXCOP00000025464	SprT-like N-terminal domain. (443 aa)
	RCBTB1	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	ENSXCOP00000024658	ATPase family AAA domain containing 5a. (1287 aa)
	LOC114149001	Ubiquitin-like domain-containing protein. (77 aa)
	Vcp	Valosin containing protein; Belongs to the AAA ATPase family. (761 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	SPATA5	Spermatogenesis associated 5; Belongs to the AAA ATPase family. (684 aa)
	ENSXCOP00000019342	Zgc:136908; Belongs to the AAA ATPase family. (725 aa)
	ENSXCOP00000018218	BRCT domain-containing protein. (450 aa)
	ENSXCOP00000018217	RFC1 domain-containing protein. (149 aa)
	ENSXCOP00000013308	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (589 aa)
	Rfc3	Replication factor C (activator 1) 3. (333 aa)
	ENSXCOP00000013093	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (554 aa)
	ENSXCOP00000011761	Uncharacterized protein. (316 aa)
	LOC114133261	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	LOC114138068	Ribosomal protein S27a. (156 aa)
	Nploc4	NPL4 homolog, ubiquitin recognition factor. (505 aa)
	Rpa3	Replication protein A3. (120 aa)
	ENSXCOP00000003814	Methionine sulfoxide reductase B1b. (403 aa)
	ENSXCOP00000002686	Ubiquitin recognition factor in ER associated degradation 1. (283 aa)
	LOC114138536	BTB domain-containing protein. (531 aa)
	rpa2	Replication protein A2. (278 aa)
	Polh	Polymerase (DNA directed), eta. (696 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXCOP00000002686	ENSXCOP00000003814	ENSXCOP00000002686	ENSXCOP00000003814	Ubiquitin recognition factor in ER associated degradation 1.	Methionine sulfoxide reductase B1b.	0.465
ENSXCOP00000002686	ENSXCOP00000013093	ENSXCOP00000002686	ENSXCOP00000013093	Ubiquitin recognition factor in ER associated degradation 1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.530
ENSXCOP00000002686	ENSXCOP00000013308	ENSXCOP00000002686	ENSXCOP00000013308	Ubiquitin recognition factor in ER associated degradation 1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.530
ENSXCOP00000002686	ENSXCOP00000018217	ENSXCOP00000002686	ENSXCOP00000018217	Ubiquitin recognition factor in ER associated degradation 1.	RFC1 domain-containing protein.	0.620
ENSXCOP00000002686	ENSXCOP00000018218	ENSXCOP00000002686	ENSXCOP00000018218	Ubiquitin recognition factor in ER associated degradation 1.	BRCT domain-containing protein.	0.620
ENSXCOP00000002686	ENSXCOP00000019342	ENSXCOP00000002686	ENSXCOP00000019342	Ubiquitin recognition factor in ER associated degradation 1.	Zgc:136908; Belongs to the AAA ATPase family.	0.965
ENSXCOP00000002686	ENSXCOP00000024658	ENSXCOP00000002686	ENSXCOP00000024658	Ubiquitin recognition factor in ER associated degradation 1.	ATPase family AAA domain containing 5a.	0.578
ENSXCOP00000002686	ENSXCOP00000025464	ENSXCOP00000002686	ENSXCOP00000025464	Ubiquitin recognition factor in ER associated degradation 1.	SprT-like N-terminal domain.	0.813
ENSXCOP00000002686	LOC114138068	ENSXCOP00000002686	ENSXCOP00000004814	Ubiquitin recognition factor in ER associated degradation 1.	Ribosomal protein S27a.	0.945
ENSXCOP00000002686	LOC114149001	ENSXCOP00000002686	ENSXCOP00000023106	Ubiquitin recognition factor in ER associated degradation 1.	Ubiquitin-like domain-containing protein.	0.822
ENSXCOP00000002686	Nploc4	ENSXCOP00000002686	ENSXCOP00000004460	Ubiquitin recognition factor in ER associated degradation 1.	NPL4 homolog, ubiquitin recognition factor.	0.973
ENSXCOP00000002686	Polh	ENSXCOP00000002686	ENSXCOP00000000415	Ubiquitin recognition factor in ER associated degradation 1.	Polymerase (DNA directed), eta.	0.755
ENSXCOP00000002686	Rfc3	ENSXCOP00000002686	ENSXCOP00000013300	Ubiquitin recognition factor in ER associated degradation 1.	Replication factor C (activator 1) 3.	0.747
ENSXCOP00000002686	Rfc4	ENSXCOP00000002686	ENSXCOP00000007624	Ubiquitin recognition factor in ER associated degradation 1.	Replication factor C (activator 1) 4.	0.742
ENSXCOP00000002686	SPATA5	ENSXCOP00000002686	ENSXCOP00000020651	Ubiquitin recognition factor in ER associated degradation 1.	Spermatogenesis associated 5; Belongs to the AAA ATPase family.	0.950
ENSXCOP00000002686	Vcp	ENSXCOP00000002686	ENSXCOP00000022613	Ubiquitin recognition factor in ER associated degradation 1.	Valosin containing protein; Belongs to the AAA ATPase family.	0.965
ENSXCOP00000002686	pcna	ENSXCOP00000002686	ENSXCOP00000006594	Ubiquitin recognition factor in ER associated degradation 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.730
ENSXCOP00000002686	rfc2	ENSXCOP00000002686	ENSXCOP00000022248	Ubiquitin recognition factor in ER associated degradation 1.	Replication factor C (activator 1) 2.	0.742
ENSXCOP00000002686	rpa2	ENSXCOP00000002686	ENSXCOP00000000909	Ubiquitin recognition factor in ER associated degradation 1.	Replication protein A2.	0.568
ENSXCOP00000002686	uba52	ENSXCOP00000002686	ENSXCOP00000007438	Ubiquitin recognition factor in ER associated degradation 1.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.822