(37 nodes) RAF-independent MAPK1/3 activation network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	Dusp7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa)
	Styx	Serine/threonine/tyrosine interacting protein. (219 aa)
	Dusp16	Dual specificity phosphatase 16. (370 aa)
	ENSXCOP00000024246	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (407 aa)
	ENSXCOP00000026202	IG domain-containing protein. (539 aa)
	LOC114138196	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
	ENSXCOP00000015446	Dual specificity phosphatase 22a. (202 aa)
	Mapk1	Mitogen-activated protein kinase. (357 aa)
	ENSXCOP00000012978	Slingshot protein phosphatase 2b. (702 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	ENSXCOP00000012623	Tyrosine-protein kinase. (1119 aa)
	dusp1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	ENSXCOP00000010958	Tyrosine-protein kinase. (1075 aa)
	Dusp19	Dual specificity phosphatase 19a. (215 aa)
	Dusp12	Dual specificity phosphatase 12. (297 aa)
	pea15	Proliferation and apoptosis adaptor protein 15. (130 aa)
	ENSXCOP00000007566	Si:dkey-175m17.7. (865 aa)
	LOC114149259	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
	LOC114149322	Tyrosine-protein kinase. (1124 aa)
	Dusp22	Uncharacterized protein. (162 aa)
	dusp6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (388 aa)
	ENSXCOP00000004172	Uncharacterized protein. (112 aa)
	ENSXCOP00000003969	Si:ch211-203d1.3. (594 aa)
	Dusp10	Dual specificity phosphatase 10. (200 aa)
	ENSXCOP00000002847	Dual specificity phosphatase 10. (162 aa)
	ENSXCOP00000023001	Slingshot protein phosphatase 1a. (674 aa)
	ENSXCOP00000002211	Rhodanese domain-containing protein. (190 aa)
	Dusp8	Dual specificity phosphatase 8a. (656 aa)
	LOC114138163	Uncharacterized protein. (203 aa)
	Cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (224 aa)
	dusp5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	ENSXCOP00000019985	Dual specificity phosphatase 22b. (160 aa)
	Dusp28	Dual specificity phosphatase 28. (158 aa)
	ENSXCOP00000002312	Slingshot protein phosphatase 2a. (860 aa)
	ENSXCOP00000002501	Uncharacterized protein. (196 aa)
	Mob2	MOB kinase activator 2a. (243 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdk1	ENSXCOP00000024246	ENSXCOP00000018783	ENSXCOP00000024246	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.416
Cdk1	Mapk1	ENSXCOP00000018783	ENSXCOP00000014487	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.420
Cdk1	map2k1	ENSXCOP00000018783	ENSXCOP00000000126	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.582
Cdk1	map2k2	ENSXCOP00000018783	ENSXCOP00000012706	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily.	0.579
Dusp10	ENSXCOP00000002847	ENSXCOP00000002850	ENSXCOP00000002847	Dual specificity phosphatase 10.	Dual specificity phosphatase 10.	0.899
Dusp10	ENSXCOP00000024246	ENSXCOP00000002850	ENSXCOP00000024246	Dual specificity phosphatase 10.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.952
Dusp10	Mapk1	ENSXCOP00000002850	ENSXCOP00000014487	Dual specificity phosphatase 10.	Mitogen-activated protein kinase.	0.952
Dusp12	ENSXCOP00000024246	ENSXCOP00000010626	ENSXCOP00000024246	Dual specificity phosphatase 12.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.433
Dusp12	Mapk1	ENSXCOP00000010626	ENSXCOP00000014487	Dual specificity phosphatase 12.	Mitogen-activated protein kinase.	0.433
Dusp16	ENSXCOP00000024246	ENSXCOP00000015845	ENSXCOP00000024246	Dual specificity phosphatase 16.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.952
Dusp16	Mapk1	ENSXCOP00000015845	ENSXCOP00000014487	Dual specificity phosphatase 16.	Mitogen-activated protein kinase.	0.952
Dusp7	ENSXCOP00000024246	ENSXCOP00000017988	ENSXCOP00000024246	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.980
Dusp7	Mapk1	ENSXCOP00000017988	ENSXCOP00000014487	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.980
Dusp8	ENSXCOP00000002211	ENSXCOP00000002799	ENSXCOP00000002211	Dual specificity phosphatase 8a.	Rhodanese domain-containing protein.	0.705
Dusp8	ENSXCOP00000024246	ENSXCOP00000002799	ENSXCOP00000024246	Dual specificity phosphatase 8a.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.952
Dusp8	Mapk1	ENSXCOP00000002799	ENSXCOP00000014487	Dual specificity phosphatase 8a.	Mitogen-activated protein kinase.	0.952
ENSXCOP00000002211	Dusp8	ENSXCOP00000002211	ENSXCOP00000002799	Rhodanese domain-containing protein.	Dual specificity phosphatase 8a.	0.705
ENSXCOP00000002211	ENSXCOP00000024246	ENSXCOP00000002211	ENSXCOP00000024246	Rhodanese domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.542
ENSXCOP00000002211	Mapk1	ENSXCOP00000002211	ENSXCOP00000014487	Rhodanese domain-containing protein.	Mitogen-activated protein kinase.	0.542
ENSXCOP00000002847	Dusp10	ENSXCOP00000002847	ENSXCOP00000002850	Dual specificity phosphatase 10.	Dual specificity phosphatase 10.	0.899