(83 nodes) Downstream signaling events of B Cell Receptor (BCR) network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Psmc4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (401 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (605 aa)
	Psmc5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (398 aa)
	Psma1	Proteasome subunit alpha type. (262 aa)
	PSMA4	Proteasome subunit beta; Belongs to the peptidase T1B family. (237 aa)
	ENSXCOP00000001031	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (433 aa)
	ENSXCOP00000001107	RHD domain-containing protein. (452 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (212 aa)
	Nfatc1	RHD domain-containing protein. (674 aa)
	Psmd5	Proteasome 26S subunit, non-ATPase 5. (505 aa)
	Psmd14	Proteasome 26S subunit, non-ATPase 14. (302 aa)
	ENSXCOP00000002136	Inhibitor of nuclear factor kappa B kinase subunit beta. (708 aa)
	nfkbie	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon. (343 aa)
	ENSXCOP00000003123	Proteasome inhibitor subunit 1. (267 aa)
	ENSXCOP00000004149	PI31_Prot_N domain-containing protein. (154 aa)
	Psmd1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (951 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (733 aa)
	LOC114138068	Ribosomal protein S27a. (156 aa)
	Psme3	Proteasome activator subunit 3. (255 aa)
	skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	Psme1	Proteasome activator subunit 1. (259 aa)
	ENSXCOP00000007098	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (301 aa)
	ENSXCOP00000007366	Proteasome activator subunit 4b. (1682 aa)
	LOC114157395	V-rel avian reticuloendotheliosis viral oncogene homolog A. (628 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	psmc6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	REL	REL proto-oncogene, NF-kB subunit. (624 aa)
	PAFAH1B1-2	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (396 aa)
	LOC114147096	Proteasome subunit beta. (271 aa)
	ENSXCOP00000010336	Proteasome subunit beta. (287 aa)
	Fkbp1b	Peptidylprolyl isomerase. (110 aa)
	Psmc1	Proteasome 26S subunit, ATPase 1b. (257 aa)
	LOC114158792	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (301 aa)
	ENSXCOP00000011179	Proteasome subunit alpha type. (233 aa)
	ENSXCOP00000011233	Proteasome subunit beta. (287 aa)
	ENSXCOP00000012693	Proteasome 26S subunit, non-ATPase 13. (357 aa)
	ENSXCOP00000012718	MALT paracaspase 1. (782 aa)
	Psme4	Proteasome activator subunit 4a. (1804 aa)
	psmd6	Proteasome 26S subunit, non-ATPase 6. (389 aa)
	ENSXCOP00000013978	Proteasome 26S subunit, non-ATPase 11a. (420 aa)
	ENSXCOP00000014064	RHD domain-containing protein. (225 aa)
	ENSXCOP00000014609	Proteasome subunit beta 8A. (160 aa)
	Psmd10	ANK_REP_REGION domain-containing protein. (73 aa)
	ENSXCOP00000014928	Nuclear factor of activated T cells 5b. (1332 aa)
	Psmb3	Proteasome subunit beta. (204 aa)
	ENSXCOP00000015859	Component of inhibitor of nuclear factor kappa B kinase complex. (701 aa)
	Psmc3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (421 aa)
	Psmb1	Proteasome subunit beta. (240 aa)
	Nfatc3	Nuclear factor of activated T cells 3a. (1069 aa)
	ENSXCOP00000016650	Serine/threonine-protein phosphatase. (476 aa)
	PAFAH1B1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (426 aa)
	Psmb6	Proteasome subunit beta 6. (251 aa)
	wdr92	WD repeat domain 92. (358 aa)
	PPP3R1	Protein phosphatase 3 regulatory subunit B, alpha. (184 aa)
	Psma6	Proteasome subunit alpha type. (252 aa)
	Nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (323 aa)
	ENSXCOP00000018793	Proteasome subunit beta 13a. (218 aa)
	ENSXCOP00000018797	Proteasome subunit beta 12. (192 aa)
	ENSXCOP00000018801	Proteasome subunit beta 9a. (170 aa)
	LOC114140892	Peptidylprolyl isomerase. (109 aa)
	psma8	Proteasome subunit alpha type. (251 aa)
	Psmd12	Proteasome 26S subunit, non-ATPase 12. (436 aa)
	ENSXCOP00000020233	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (393 aa)
	Psme2	Proteasome activator subunit 2. (273 aa)
	Cul1	Cullin 1b; Belongs to the cullin family. (332 aa)
	psmb7	Proteasome subunit beta. (298 aa)
	Psma2	Proteasome endopeptidase complex. (164 aa)
	LOC114149126	Proteasome subunit beta. (301 aa)
	ENSXCOP00000022928	Serine/threonine-protein phosphatase. (490 aa)
	LOC114149001	Ubiquitin-like domain-containing protein. (77 aa)
	ENSXCOP00000023718	Caspase recruitment domain family, member 11. (944 aa)
	ENSXCOP00000024324	Proteasome 26S subunit, non-ATPase 3. (462 aa)
	LOC114160036	Zgc:55558. (187 aa)
	psma5	Proteasome subunit alpha type. (241 aa)
	ENSXCOP00000025153	Nuclear factor of activated T cells 1. (395 aa)
	psmb2	Proteasome subunit beta. (199 aa)
	psmb4	Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
	ENSXCOP00000026215	Proteasome 26S subunit, non-ATPase 4b. (350 aa)
	ENSXCOP00000027078	MALT paracaspase 3. (570 aa)
	ENSXCOP00000027341	Nuclear factor of activated T cells 5a. (1399 aa)
	psmd7	Proteasome 26S subunit, non-ATPase 7. (330 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	Cul1	ENSXCOP00000004485	ENSXCOP00000021184	Component of inhibitor of nuclear factor kappa B kinase complex.	Cullin 1b; Belongs to the cullin family.	0.571
CHUK	ENSXCOP00000001031	ENSXCOP00000004485	ENSXCOP00000001031	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.819
CHUK	ENSXCOP00000002136	ENSXCOP00000004485	ENSXCOP00000002136	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.499
CHUK	ENSXCOP00000012718	ENSXCOP00000004485	ENSXCOP00000012718	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 1.	0.465
CHUK	ENSXCOP00000015859	ENSXCOP00000004485	ENSXCOP00000015859	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.431
CHUK	ENSXCOP00000023718	ENSXCOP00000004485	ENSXCOP00000023718	Component of inhibitor of nuclear factor kappa B kinase complex.	Caspase recruitment domain family, member 11.	0.602
CHUK	ENSXCOP00000027078	ENSXCOP00000004485	ENSXCOP00000027078	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 3.	0.465
CHUK	LOC114138068	ENSXCOP00000004485	ENSXCOP00000004814	Component of inhibitor of nuclear factor kappa B kinase complex.	Ribosomal protein S27a.	0.579
CHUK	LOC114149001	ENSXCOP00000004485	ENSXCOP00000023106	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-like domain-containing protein.	0.532
CHUK	LOC114157395	ENSXCOP00000004485	ENSXCOP00000007384	Component of inhibitor of nuclear factor kappa B kinase complex.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.642
CHUK	LOC114158792	ENSXCOP00000004485	ENSXCOP00000011178	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.568
CHUK	Nfkbia	ENSXCOP00000004485	ENSXCOP00000018615	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.568
CHUK	REL	ENSXCOP00000004485	ENSXCOP00000008647	Component of inhibitor of nuclear factor kappa B kinase complex.	REL proto-oncogene, NF-kB subunit.	0.642
CHUK	nfkbie	ENSXCOP00000004485	ENSXCOP00000002821	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon.	0.568
CHUK	skp1	ENSXCOP00000004485	ENSXCOP00000005302	Component of inhibitor of nuclear factor kappa B kinase complex.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.553
CHUK	uba52	ENSXCOP00000004485	ENSXCOP00000007438	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.532
CSDE1	LOC114138068	ENSXCOP00000000038	ENSXCOP00000004814	Cold shock domain containing E1, RNA-binding.	Ribosomal protein S27a.	0.484
CSDE1	LOC114149001	ENSXCOP00000000038	ENSXCOP00000023106	Cold shock domain containing E1, RNA-binding.	Ubiquitin-like domain-containing protein.	0.442
CSDE1	uba52	ENSXCOP00000000038	ENSXCOP00000007438	Cold shock domain containing E1, RNA-binding.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.442
Cul1	CHUK	ENSXCOP00000021184	ENSXCOP00000004485	Cullin 1b; Belongs to the cullin family.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.571