64 items (Xiphophorus couchianus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXCOP00000010603	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (605 aa)
	LOC114140865	Tyrosine-protein kinase. (527 aa)
	Grb2	Growth factor receptor-bound protein 2b. (210 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (466 aa)
	ENSXCOP00000003816	Uncharacterized protein. (282 aa)
	LOC114138068	Ribosomal protein S27a. (156 aa)
	ENSXCOP00000004855	Leucine-rich repeats and immunoglobulin-like domains 3. (688 aa)
	ENSXCOP00000005262	Protein tyrosine phosphatase receptor type K. (1333 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	Fndc3a	Fibronectin type III domain containing 3A. (1215 aa)
	ENSXCOP00000008291	Sprouty homolog 4 (Drosophila). (289 aa)
	ENSXCOP00000008580	Tyrosine-protein phosphatase domain-containing protein. (255 aa)
	ENSXCOP00000009526	PH domain-containing protein. (389 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	ENSXCOP00000010032	Uncharacterized protein. (363 aa)
	Cblc	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (507 aa)
	ENSXCOP00000010389	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (545 aa)
	ENSXCOP00000010806	SH3-domain GRB2-like 1a. (342 aa)
	ENSXCOP00000010846	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (944 aa)
	ENSXCOP00000010848	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (128 aa)
	ENSXCOP00000011610	Transforming growth factor, alpha. (139 aa)
	LOC114139518	Heparin-binding EGF-like growth factor a. (236 aa)
	LOC114154014	EGF-like domain-containing protein. (164 aa)
	ENSXCOP00000012555	EGF-like domain-containing protein. (132 aa)
	Sh3gl1	SH3-domain GRB2-like 1b. (348 aa)
	LOC114147918	Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2. (517 aa)
	ENSXCOP00000014285	Uncharacterized protein. (383 aa)
	Eps15	EH domain-containing protein. (95 aa)
	Hgs	Hepatocyte growth factor-regulated tyrosine kinase substrate. (737 aa)
	ENSXCOP00000014629	SH3 domain containing GRB2 like 2a, endophilin A1. (338 aa)
	ENSXCOP00000014719	GRB2-associated binding protein 1. (697 aa)
	ENSXCOP00000016904	Cbl proto-oncogene, E3 ubiquitin protein ligase. (903 aa)
	ENSXCOP00000016923	Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family. (209 aa)
	ENSXCOP00000017117	SH3 domain containing 21. (423 aa)
	Fndc3b	Fibronectin type III domain containing 3Ba. (1174 aa)
	CDC42	Cell division cycle 42. (191 aa)
	Sh3kbp1	SH3-domain kinase binding protein 1. (530 aa)
	ENSXCOP00000020656	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (272 aa)
	ENSXCOP00000021881	Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (489 aa)
	ENSXCOP00000021910	Tyrosine-protein kinase. (445 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	ENSXCOP00000022953	Ig-like domain-containing protein. (134 aa)
	ENSXCOP00000022956	Uncharacterized protein. (115 aa)
	LOC114149001	Ubiquitin-like domain-containing protein. (77 aa)
	Spry2	Sprouty RTK signaling antagonist 2. (354 aa)
	ENSXCOP00000023583	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (519 aa)
	ENSXCOP00000023584	Uncharacterized protein. (204 aa)
	LOC114160036	Zgc:55558. (187 aa)
	ENSXCOP00000024891	UBA domain-containing protein. (130 aa)
	CBL	Uncharacterized protein. (479 aa)
	EPS15L1	Epidermal growth factor receptor pathway substrate 15 like 1. (431 aa)
	ENSXCOP00000025136	Rho guanine nucleotide exchange factor (GEF) 7a. (402 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (405 aa)
	ENSXCOP00000025535	Uncharacterized protein. (196 aa)
	LOC114142284	Uncharacterized protein. (191 aa)
	Ptprm	Uncharacterized protein. (330 aa)
	ENSXCOP00000025800	Uncharacterized protein. (298 aa)
	ENSXCOP00000026173	SHC (Src homology 2 domain containing) transforming protein 1. (459 aa)
	ENSXCOP00000026295	Protein tyrosine phosphatase non-receptor type 3. (757 aa)
	ENSXCOP00000027171	Rho guanine nucleotide exchange factor (GEF) 7b. (520 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	aamp	Angio-associated, migratory cell protein. (418 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF7	CBL	ENSXCOP00000025139	ENSXCOP00000024893	Rho guanine nucleotide exchange factor 7.	Uncharacterized protein.	0.532
ARHGEF7	CDC42	ENSXCOP00000025139	ENSXCOP00000018921	Rho guanine nucleotide exchange factor 7.	Cell division cycle 42.	0.737
ARHGEF7	Cblc	ENSXCOP00000025139	ENSXCOP00000010328	Rho guanine nucleotide exchange factor 7.	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.532
ARHGEF7	ENSXCOP00000012555	ENSXCOP00000025139	ENSXCOP00000012555	Rho guanine nucleotide exchange factor 7.	EGF-like domain-containing protein.	0.432
ARHGEF7	ENSXCOP00000016904	ENSXCOP00000025139	ENSXCOP00000016904	Rho guanine nucleotide exchange factor 7.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.532
ARHGEF7	ENSXCOP00000024891	ENSXCOP00000025139	ENSXCOP00000024891	Rho guanine nucleotide exchange factor 7.	UBA domain-containing protein.	0.532
ARHGEF7	ENSXCOP00000025136	ENSXCOP00000025139	ENSXCOP00000025136	Rho guanine nucleotide exchange factor 7.	Rho guanine nucleotide exchange factor (GEF) 7a.	0.891
ARHGEF7	ENSXCOP00000025535	ENSXCOP00000025139	ENSXCOP00000025535	Rho guanine nucleotide exchange factor 7.	Uncharacterized protein.	0.609
ARHGEF7	Grb2	ENSXCOP00000025139	ENSXCOP00000000623	Rho guanine nucleotide exchange factor 7.	Growth factor receptor-bound protein 2b.	0.476
ARHGEF7	LOC114142284	ENSXCOP00000025139	ENSXCOP00000025719	Rho guanine nucleotide exchange factor 7.	Uncharacterized protein.	0.609
CBL	ARHGEF7	ENSXCOP00000024893	ENSXCOP00000025139	Uncharacterized protein.	Rho guanine nucleotide exchange factor 7.	0.532
CBL	CDC42	ENSXCOP00000024893	ENSXCOP00000018921	Uncharacterized protein.	Cell division cycle 42.	0.548
CBL	Cblc	ENSXCOP00000024893	ENSXCOP00000010328	Uncharacterized protein.	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.902
CBL	ENSXCOP00000008291	ENSXCOP00000024893	ENSXCOP00000008291	Uncharacterized protein.	Sprouty homolog 4 (Drosophila).	0.785
CBL	ENSXCOP00000010032	ENSXCOP00000024893	ENSXCOP00000010032	Uncharacterized protein.	Uncharacterized protein.	0.417
CBL	ENSXCOP00000010603	ENSXCOP00000024893	ENSXCOP00000010603	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.407
CBL	ENSXCOP00000010806	ENSXCOP00000024893	ENSXCOP00000010806	Uncharacterized protein.	SH3-domain GRB2-like 1a.	0.415
CBL	ENSXCOP00000010846	ENSXCOP00000024893	ENSXCOP00000010846	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.406
CBL	ENSXCOP00000010848	ENSXCOP00000024893	ENSXCOP00000010848	Uncharacterized protein.	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.406
CBL	ENSXCOP00000011610	ENSXCOP00000024893	ENSXCOP00000011610	Uncharacterized protein.	Transforming growth factor, alpha.	0.445