(32 nodes) Downstream signal transduction network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXCOP00000013173	Cas scaffold protein family member 4. (750 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	nck2	Cytoplasmic protein. (396 aa)
	LOC114160036	Zgc:55558. (187 aa)
	ENSXCOP00000023958	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (476 aa)
	ENSXCOP00000022271	Signal transducer and activator of transcription. (695 aa)
	ENSXCOP00000022345	RAS p21 protein activator (GTPase activating protein) 1a. (983 aa)
	ENSXCOP00000022656	STAT_int domain-containing protein. (442 aa)
	ENSXCOP00000010603	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	ENSXCOP00000008377	Signal transducer and activator of transcription. (681 aa)
	Fndc3a	Fibronectin type III domain containing 3A. (1215 aa)
	ENSXCOP00000007202	BCAR1 scaffold protein, Cas family member. (897 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (299 aa)
	Pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	CRK	CRK proto-oncogene, adaptor protein. (315 aa)
	Pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1037 aa)
	Nedd9	Neural precursor cell expressed, developmentally down-regulated 9. (790 aa)
	ENSXCOP00000001764	Rap guanine nucleotide exchange factor (GEF) 1b. (1048 aa)
	Grb2	Growth factor receptor-bound protein 2b. (210 aa)
	LOC114140865	Tyrosine-protein kinase. (527 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (605 aa)
	ENSXCOP00000010848	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (128 aa)
	ENSXCOP00000010846	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (944 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	ENSXCOP00000021977	Signal transducer and activator of transcription. (722 aa)
	ENSXCOP00000021202	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (475 aa)
	ENSXCOP00000021130	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (191 aa)
	Fndc3b	Fibronectin type III domain containing 3Ba. (1174 aa)
	nck1	Cytoplasmic protein. (394 aa)
	ENSXCOP00000013751	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (197 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRK	ENSXCOP00000001764	ENSXCOP00000005850	ENSXCOP00000001764	CRK proto-oncogene, adaptor protein.	Rap guanine nucleotide exchange factor (GEF) 1b.	0.954
CRK	ENSXCOP00000007202	ENSXCOP00000005850	ENSXCOP00000007202	CRK proto-oncogene, adaptor protein.	BCAR1 scaffold protein, Cas family member.	0.802
CRK	ENSXCOP00000013173	ENSXCOP00000005850	ENSXCOP00000013173	CRK proto-oncogene, adaptor protein.	Cas scaffold protein family member 4.	0.723
CRK	ENSXCOP00000021202	ENSXCOP00000005850	ENSXCOP00000021202	CRK proto-oncogene, adaptor protein.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.500
CRK	ENSXCOP00000022345	ENSXCOP00000005850	ENSXCOP00000022345	CRK proto-oncogene, adaptor protein.	RAS p21 protein activator (GTPase activating protein) 1a.	0.468
CRK	ENSXCOP00000023958	ENSXCOP00000005850	ENSXCOP00000023958	CRK proto-oncogene, adaptor protein.	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	0.500
CRK	Grb2	ENSXCOP00000005850	ENSXCOP00000000623	CRK proto-oncogene, adaptor protein.	Growth factor receptor-bound protein 2b.	0.835
CRK	LOC114140865	ENSXCOP00000005850	ENSXCOP00000000604	CRK proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.525
CRK	Nedd9	ENSXCOP00000005850	ENSXCOP00000001791	CRK proto-oncogene, adaptor protein.	Neural precursor cell expressed, developmentally down-regulated 9.	0.802
CRK	Pdgfrb	ENSXCOP00000005850	ENSXCOP00000004128	CRK proto-oncogene, adaptor protein.	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.652
CRK	SRC	ENSXCOP00000005850	ENSXCOP00000021988	CRK proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.525
CRK	crkl	ENSXCOP00000005850	ENSXCOP00000006931	CRK proto-oncogene, adaptor protein.	V-crk avian sarcoma virus CT10 oncogene homolog-like.	0.912
CSDE1	ENSXCOP00000001764	ENSXCOP00000000038	ENSXCOP00000001764	Cold shock domain containing E1, RNA-binding.	Rap guanine nucleotide exchange factor (GEF) 1b.	0.484
CSDE1	ENSXCOP00000010846	ENSXCOP00000000038	ENSXCOP00000010846	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.526
CSDE1	ENSXCOP00000010848	ENSXCOP00000000038	ENSXCOP00000010848	Cold shock domain containing E1, RNA-binding.	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.526
CSDE1	ENSXCOP00000022345	ENSXCOP00000000038	ENSXCOP00000022345	Cold shock domain containing E1, RNA-binding.	RAS p21 protein activator (GTPase activating protein) 1a.	0.794
CSDE1	Grb2	ENSXCOP00000000038	ENSXCOP00000000623	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.666
CSDE1	LOC114140865	ENSXCOP00000000038	ENSXCOP00000000604	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.417
CSDE1	PIK3CA	ENSXCOP00000000038	ENSXCOP00000009802	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.526
CSDE1	Pdgfrb	ENSXCOP00000000038	ENSXCOP00000004128	Cold shock domain containing E1, RNA-binding.	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.481