(89 nodes) Signaling by NTRK1 (TRKA) network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXCOP00000010079	Adaptor related protein complex 2 subunit alpha 1. (307 aa)
	ENSXCOP00000027869	Fibroblast growth factor receptor substrate 2b. (498 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)
	ENSXCOP00000027594	Achaete-scute family bHLH transcription factor 1b. (179 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	ENSXCOP00000027368	cAMP responsive element binding protein 1. (324 aa)
	ENSXCOP00000026934	Tribbles pseudokinase 1. (354 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (417 aa)
	ENSXCOP00000026408	Kinase D-interacting substrate 220b. (1616 aa)
	ENSXCOP00000026242	Activating transcription factor 1. (275 aa)
	ENSXCOP00000025779	Uncharacterized protein. (1773 aa)
	ENSXCOP00000025430	Uncharacterized protein. (383 aa)
	ENSXCOP00000025356	Insulin receptor substrate 2b. (999 aa)
	ENSXCOP00000024822	cAMP responsive element binding protein 1b. (280 aa)
	ENSXCOP00000024734	NGFI-A binding protein 2 (EGR1 binding protein 2). (499 aa)
	ENSXCOP00000024620	Mitogen-activated protein kinase 14b. (103 aa)
	ENSXCOP00000024537	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (402 aa)
	LOC114160036	Zgc:55558. (187 aa)
	ENSXCOP00000024246	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (407 aa)
	ENSXCOP00000023803	Alpha_adaptinC2 domain-containing protein. (850 aa)
	ENSXCOP00000023298	Insulin receptor substrate 2a. (1039 aa)
	ENSXCOP00000023163	MAPK activated protein kinase 3. (302 aa)
	ENSXCOP00000022843	Inhibitor of DNA binding 4. (157 aa)
	ENSXCOP00000022586	Uncharacterized protein. (333 aa)
	nab1	NGFI-A binding protein 1a (EGR1 binding protein 1). (508 aa)
	Ppp4r1	Uncharacterized protein. (219 aa)
	ENSXCOP00000022020	WRNPLPNID domain-containing protein. (234 aa)
	ENSXCOP00000022016	Uncharacterized protein. (186 aa)
	Egr3	Early growth response 3. (419 aa)
	LOC114136304	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (194 aa)
	Dnal4	Dynein light chain. (101 aa)
	fosl1	FOS-like antigen 1a. (337 aa)
	ENSXCOP00000019705	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (235 aa)
	ralb	V-ral simian leukemia viral oncogene homolog Ba (ras related). (207 aa)
	Dusp7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa)
	Ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (150 aa)
	ENSXCOP00000016598	Serine/threonine-protein phosphatase. (300 aa)
	LOC114144525	JunB proto-oncogene, AP-1 transcription factor subunit a. (330 aa)
	ENSXCOP00000015604	Ribosomal protein S6 kinase. (744 aa)
	ENSXCOP00000015339	Mitogen-activated protein kinase. (353 aa)
	ENSXCOP00000015144	VRK serine/threonine kinase 3. (408 aa)
	ENSXCOP00000014629	SH3 domain containing GRB2 like 2a, endophilin A1. (338 aa)
	Mapk1	Mitogen-activated protein kinase. (357 aa)
	ENSXCOP00000014403	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (195 aa)
	LOC114140641	Uncharacterized protein. (200 aa)
	RALGDS	Ral guanine nucleotide dissociation stimulator. (769 aa)
	ENSXCOP00000013609	MADS-box domain-containing protein. (313 aa)
	ENSXCOP00000013416	SHC (Src homology 2 domain containing) transforming protein 2. (386 aa)
	ENSXCOP00000013024	Adaptin_N domain-containing protein. (120 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	ENSXCOP00000012398	ETS domain-containing protein. (233 aa)
	LOC114138792	Serine/threonine-protein phosphatase. (309 aa)
	ENSXCOP00000010848	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (128 aa)
	ENSXCOP00000010846	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (944 aa)
	Ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (358 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	LOC114153742	AP complex subunit beta. (939 aa)
	trib2	Tribbles pseudokinase 2. (344 aa)
	ENSXCOP00000010072	Adaptin_N domain-containing protein. (247 aa)
	ENSXCOP00000010032	Uncharacterized protein. (363 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	LOC114146994	JunD proto-oncogene, AP-1 transcription factor subunit. (281 aa)
	ENSXCOP00000008470	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1114 aa)
	ENSXCOP00000008316	BZIP domain-containing protein. (106 aa)
	ENSXCOP00000007528	Ribosomal protein S6 kinase. (789 aa)
	JUND	BZIP domain-containing protein. (314 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (299 aa)
	SGK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (420 aa)
	Pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	ENSXCOP00000006399	Inhibitor of DNA binding 3. (117 aa)
	Rps6ka1	Non-specific serine/threonine protein kinase. (681 aa)
	ENSXCOP00000006173	BZIP domain-containing protein. (91 aa)
	CRK	CRK proto-oncogene, adaptor protein. (315 aa)
	Ppp2ca	Serine/threonine-protein phosphatase. (221 aa)
	ENSXCOP00000004961	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (229 aa)
	ENSXCOP00000004885	Protein kinase domain-containing protein. (209 aa)
	dusp6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (388 aa)
	Shc3	PID domain-containing protein. (119 aa)
	ENSXCOP00000002728	Formin binding protein 4. (706 aa)
	ENSXCOP00000002420	NTPase, KAP family P-loop domain containing 1. (520 aa)
	ENSXCOP00000002414	NTPase, KAP family P-loop domain containing 1. (529 aa)
	ENSXCOP00000001764	Rap guanine nucleotide exchange factor (GEF) 1b. (1048 aa)
	ENSXCOP00000001713	Protein kinase domain-containing protein. (199 aa)
	ENSXCOP00000001246	Uncharacterized protein. (110 aa)
	Ppp4r4	Uncharacterized protein. (156 aa)
	ENSXCOP00000000555	Early growth response 2b. (428 aa)
	Rps6ka5	Ribosomal protein S6 kinase, polypeptide 5; Belongs to the protein kinase superfamily. (413 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (605 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ap2m1	Ap2s1	ENSXCOP00000010657	ENSXCOP00000016796	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
Ap2m1	Dnal4	ENSXCOP00000010657	ENSXCOP00000021144	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Dynein light chain.	0.539
Ap2m1	ENSXCOP00000004885	ENSXCOP00000010657	ENSXCOP00000004885	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Protein kinase domain-containing protein.	0.444
Ap2m1	ENSXCOP00000010032	ENSXCOP00000010657	ENSXCOP00000010032	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Uncharacterized protein.	0.580
Ap2m1	ENSXCOP00000010072	ENSXCOP00000010657	ENSXCOP00000010072	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Adaptin_N domain-containing protein.	0.998
Ap2m1	ENSXCOP00000010079	ENSXCOP00000010657	ENSXCOP00000010079	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Adaptor related protein complex 2 subunit alpha 1.	0.987
Ap2m1	ENSXCOP00000013024	ENSXCOP00000010657	ENSXCOP00000013024	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Adaptin_N domain-containing protein.	0.996
Ap2m1	ENSXCOP00000014629	ENSXCOP00000010657	ENSXCOP00000014629	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	SH3 domain containing GRB2 like 2a, endophilin A1.	0.580
Ap2m1	ENSXCOP00000015339	ENSXCOP00000010657	ENSXCOP00000015339	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Mitogen-activated protein kinase.	0.444
Ap2m1	ENSXCOP00000019705	ENSXCOP00000010657	ENSXCOP00000019705	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.901
Ap2m1	ENSXCOP00000023298	ENSXCOP00000010657	ENSXCOP00000023298	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Insulin receptor substrate 2a.	0.448
Ap2m1	ENSXCOP00000023803	ENSXCOP00000010657	ENSXCOP00000023803	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Alpha_adaptinC2 domain-containing protein.	0.974
Ap2m1	ENSXCOP00000024246	ENSXCOP00000010657	ENSXCOP00000024246	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.552
Ap2m1	ENSXCOP00000024620	ENSXCOP00000010657	ENSXCOP00000024620	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Mitogen-activated protein kinase 14b.	0.444
Ap2m1	ENSXCOP00000025356	ENSXCOP00000010657	ENSXCOP00000025356	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Insulin receptor substrate 2b.	0.448
Ap2m1	LOC114153742	ENSXCOP00000010657	ENSXCOP00000010375	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	AP complex subunit beta.	0.997
Ap2m1	Mapk1	ENSXCOP00000010657	ENSXCOP00000014487	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Mitogen-activated protein kinase.	0.552
Ap2s1	Ap2m1	ENSXCOP00000016796	ENSXCOP00000010657	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
Ap2s1	Dnal4	ENSXCOP00000016796	ENSXCOP00000021144	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Dynein light chain.	0.533
Ap2s1	ENSXCOP00000004885	ENSXCOP00000016796	ENSXCOP00000004885	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Protein kinase domain-containing protein.	0.434