STRINGSTRING
ENSXCOP00000024230 ENSXCOP00000024230 Ccne1 Ccne1 ccnd1 ccnd1 ENSXCOP00000023621 ENSXCOP00000023621 LOC114149001 LOC114149001 LOC114149126 LOC114149126 Pole Pole ENSXCOP00000000012 ENSXCOP00000000012 Psmc5 Psmc5 Psma1 Psma1 LOC114140865 LOC114140865 PSMA4 PSMA4 rpa2 rpa2 mcm7 mcm7 Ppp4r4 Ppp4r4 ENSXCOP00000001246 ENSXCOP00000001246 ENSXCOP00000001390 ENSXCOP00000001390 psmd9 psmd9 Psmd5 Psmd5 Psma2 Psma2 ENSXCOP00000022541 ENSXCOP00000022541 ENSXCOP00000022524 ENSXCOP00000022524 Orc4 Orc4 Ccnh Ccnh Ppp4r1 Ppp4r1 ENSXCOP00000022020 ENSXCOP00000022020 ENSXCOP00000022016 ENSXCOP00000022016 SRC SRC psmb7 psmb7 ENSXCOP00000021665 ENSXCOP00000021665 ENSXCOP00000021664 ENSXCOP00000021664 ENSXCOP00000021522 ENSXCOP00000021522 Cables1 Cables1 Cul1 Cul1 ENSXCOP00000021077 ENSXCOP00000021077 ENSXCOP00000020986 ENSXCOP00000020986 ENSXCOP00000020723 ENSXCOP00000020723 Psme2 Psme2 ENSXCOP00000020405 ENSXCOP00000020405 ENSXCOP00000020233 ENSXCOP00000020233 ENSXCOP00000020133 ENSXCOP00000020133 ccna2 ccna2 Psmd12 Psmd12 ENSXCOP00000019701 ENSXCOP00000019701 LOC114160673 LOC114160673 ENSXCOP00000019065 ENSXCOP00000019065 ENSXCOP00000018871 ENSXCOP00000018871 Fndc3b Fndc3b ENSXCOP00000018820 ENSXCOP00000018820 ENSXCOP00000018801 ENSXCOP00000018801 Psmd14 Psmd14 Lin37 Lin37 LOC114161603 LOC114161603 pola2 pola2 ENSXCOP00000002728 ENSXCOP00000002728 ENSXCOP00000003114 ENSXCOP00000003114 ENSXCOP00000003123 ENSXCOP00000003123 LOC114149228 LOC114149228 ENSXCOP00000003215 ENSXCOP00000003215 ENSXCOP00000003408 ENSXCOP00000003408 Abl1 Abl1 ENSXCOP00000003814 ENSXCOP00000003814 Rpa3 Rpa3 ENSXCOP00000004053 ENSXCOP00000004053 ENSXCOP00000004149 ENSXCOP00000004149 Psmd1 Psmd1 ENSXCOP00000004330 ENSXCOP00000004330 Mcm10 Mcm10 ENSXCOP00000004664 ENSXCOP00000004664 LOC114136223 LOC114136223 LOC114138068 LOC114138068 ENSXCOP00000004968 ENSXCOP00000004968 Psme3 Psme3 skp1 skp1 Ppp2ca Ppp2ca Orc3 Orc3 Lin9 Lin9 PSMD2 PSMD2 ENSXCOP00000006371 ENSXCOP00000006371 LOC114149322 LOC114149322 Psme1 Psme1 ENSXCOP00000006969 ENSXCOP00000006969 ENSXCOP00000007098 ENSXCOP00000007098 uba52 uba52 ENSXCOP00000007470 ENSXCOP00000007470 ENSXCOP00000007574 ENSXCOP00000007574 Fndc3a Fndc3a ENSXCOP00000008263 ENSXCOP00000008263 psmc6 psmc6 ENSXCOP00000008401 ENSXCOP00000008401 ENSXCOP00000008470 ENSXCOP00000008470 ENSXCOP00000008629 ENSXCOP00000008629 ENSXCOP00000008872 ENSXCOP00000008872 ENSXCOP00000008968 ENSXCOP00000008968 ENSXCOP00000009602 ENSXCOP00000009602 LOC114147096 LOC114147096 ENSXCOP00000010411 ENSXCOP00000010411 ENSXCOP00000010446 ENSXCOP00000010446 ppp2r1b ppp2r1b Mcm2 Mcm2 ENSXCOP00000010985 ENSXCOP00000010985 ENSXCOP00000011040 ENSXCOP00000011040 Psmc1 Psmc1 ENSXCOP00000011179 ENSXCOP00000011179 Mnat1 Mnat1 LOC114138792 LOC114138792 ENSXCOP00000012493 ENSXCOP00000012493 ENSXCOP00000012623 ENSXCOP00000012623 ENSXCOP00000012693 ENSXCOP00000012693 ENSXCOP00000012819 ENSXCOP00000012819 ENSXCOP00000013093 ENSXCOP00000013093 ENSXCOP00000013308 ENSXCOP00000013308 Ccna1 Ccna1 LOC114150313 LOC114150313 Wee1 Wee1 ENSXCOP00000028006 ENSXCOP00000028006 Psmc4 Psmc4 ENSXCOP00000027383 ENSXCOP00000027383 psmd7 psmd7 ENSXCOP00000013704 ENSXCOP00000013704 psmd6 psmd6 ENSXCOP00000013978 ENSXCOP00000013978 ENSXCOP00000014070 ENSXCOP00000014070 ENSXCOP00000014165 ENSXCOP00000014165 Pole4 Pole4 Cdkn2c Cdkn2c Lin52 Lin52 ENSXCOP00000014609 ENSXCOP00000014609 Akt1 Akt1 Psmd10 Psmd10 cdkn2b cdkn2b ENSXCOP00000015019 ENSXCOP00000015019 Psmb3 Psmb3 ENSXCOP00000015223 ENSXCOP00000015223 Prim1 Prim1 ENSXCOP00000015546 ENSXCOP00000015546 Prim2 Prim2 Psmc3 Psmc3 Psmb1 Psmb1 ENSXCOP00000016598 ENSXCOP00000016598 Psmb6 Psmb6 ENSXCOP00000018797 ENSXCOP00000018797 ENSXCOP00000018793 ENSXCOP00000018793 ENSXCOP00000018558 ENSXCOP00000018558 Psma6 Psma6 LOC114160881 LOC114160881 Cdkn2d Cdkn2d ENSXCOP00000017654 ENSXCOP00000017654 ENSXCOP00000017651 ENSXCOP00000017651 Ppp2r3c Ppp2r3c gmnn gmnn ENSXCOP00000026541 ENSXCOP00000026541 ENSXCOP00000026291 ENSXCOP00000026291 ENSXCOP00000026249 ENSXCOP00000026249 ENSXCOP00000026215 ENSXCOP00000026215 psmb4 psmb4 psmb2 psmb2 Tfdp1 Tfdp1 PPP2R3B PPP2R3B Cdk4 Cdk4 CDK2 CDK2 psma5 psma5 ENSXCOP00000024324 ENSXCOP00000024324
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSXCOP00000024230Cyclin Dx; Belongs to the cyclin family. (294 aa)
Ccne1Cyclin E1; Belongs to the cyclin family. (284 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
ENSXCOP00000023621Lin-54 DREAM MuvB core complex component. (562 aa)
LOC114149001Ubiquitin-like domain-containing protein. (77 aa)
LOC114149126Proteasome subunit beta. (301 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2225 aa)
ENSXCOP00000000012E2F transcription factor 1. (426 aa)
Psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (398 aa)
Psma1Proteasome subunit alpha type. (262 aa)
LOC114140865Tyrosine-protein kinase. (527 aa)
PSMA4Proteasome subunit beta; Belongs to the peptidase T1B family. (237 aa)
rpa2Replication protein A2. (278 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa)
Ppp4r4Uncharacterized protein. (156 aa)
ENSXCOP00000001246Uncharacterized protein. (110 aa)
ENSXCOP00000001390F-box domain-containing protein. (391 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
Psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
Psma2Proteasome endopeptidase complex. (164 aa)
ENSXCOP00000022541Cyclin-dependent kinase 7. (302 aa)
ENSXCOP00000022524Tyrosine-protein kinase. (440 aa)
Orc4AAA_16 domain-containing protein. (142 aa)
CcnhCyclin H; Belongs to the cyclin family. (319 aa)
Ppp4r1Uncharacterized protein. (219 aa)
ENSXCOP00000022020WRNPLPNID domain-containing protein. (234 aa)
ENSXCOP00000022016Uncharacterized protein. (186 aa)
SRCTyrosine-protein kinase. (559 aa)
psmb7Proteasome subunit beta. (298 aa)
ENSXCOP00000021665E2F_CC-MB domain-containing protein. (213 aa)
ENSXCOP00000021664E2F transcription factor 3. (208 aa)
ENSXCOP00000021522V-myb avian myeloblastosis viral oncogene homolog-like 2b. (331 aa)
Cables1Cdk5 and Abl enzyme substrate 1. (307 aa)
Cul1Cullin 1b; Belongs to the cullin family. (332 aa)
ENSXCOP00000021077Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (444 aa)
ENSXCOP00000020986Minichromosome maintenance complex component 5; Belongs to the MCM family. (688 aa)
ENSXCOP00000020723CYCLIN domain-containing protein; Belongs to the cyclin family. (401 aa)
Psme2Proteasome activator subunit 2. (273 aa)
ENSXCOP00000020405Retinoblastoma 1. (519 aa)
ENSXCOP00000020233Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (393 aa)
ENSXCOP00000020133DNA helicase; Belongs to the MCM family. (810 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (432 aa)
Psmd12Proteasome 26S subunit, non-ATPase 12. (436 aa)
ENSXCOP00000019701Origin recognition complex, subunit 5. (400 aa)
LOC114160673Cyclin-dependent kinase inhibitor 1D. (178 aa)
ENSXCOP00000019065Cdk5 and Abl enzyme substrate 2a; Belongs to the cyclin family. (396 aa)
ENSXCOP00000018871Protein phosphatase 2, regulatory subunit B'', alpha. (1159 aa)
Fndc3bFibronectin type III domain containing 3Ba. (1174 aa)
ENSXCOP00000018820Chromatin licensing and DNA replication factor 1. (634 aa)
ENSXCOP00000018801Proteasome subunit beta 9a. (170 aa)
Psmd14Proteasome 26S subunit, non-ATPase 14. (302 aa)
Lin37Lin-37 DREAM MuvB core complex component. (238 aa)
LOC114161603Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (604 aa)
ENSXCOP00000002728Formin binding protein 4. (706 aa)
ENSXCOP00000003114Retinoblastoma-like 1 (p107). (1010 aa)
ENSXCOP00000003123Proteasome inhibitor subunit 1. (267 aa)
LOC114149228Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
ENSXCOP00000003215PROTEASOME_ALPHA_1 domain-containing protein. (77 aa)
ENSXCOP00000003408CDC45 cell division cycle 45 homolog (S. cerevisiae). (527 aa)
Abl1Protein kinase domain-containing protein. (223 aa)
ENSXCOP00000003814Methionine sulfoxide reductase B1b. (403 aa)
Rpa3Replication protein A3. (120 aa)
ENSXCOP00000004053Uncharacterized protein. (774 aa)
ENSXCOP00000004149PI31_Prot_N domain-containing protein. (154 aa)
Psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (951 aa)
ENSXCOP00000004330E2F_TDP domain-containing protein. (102 aa)
Mcm10Zf-primase domain-containing protein. (210 aa)
ENSXCOP00000004664Cyclin D3; Belongs to the cyclin family. (261 aa)
LOC114136223Cyclin-dependent kinase inhibitor 1A. (156 aa)
LOC114138068Ribosomal protein S27a. (156 aa)
ENSXCOP00000004968DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (523 aa)
Psme3Proteasome activator subunit 3. (255 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
Ppp2caSerine/threonine-protein phosphatase. (221 aa)
Orc3Origin recognition complex, subunit 3. (684 aa)
Lin9Lin-9 DREAM MuvB core complex component. (467 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (828 aa)
ENSXCOP00000006371Si:ch211-160f23.5. (434 aa)
LOC114149322Tyrosine-protein kinase. (1124 aa)
Psme1Proteasome activator subunit 1. (259 aa)
ENSXCOP00000006969Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (420 aa)
ENSXCOP00000007098Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (301 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
ENSXCOP00000007470Cyclin D2, a; Belongs to the cyclin family. (296 aa)
ENSXCOP00000007574E2F transcription factor 4. (357 aa)
Fndc3aFibronectin type III domain containing 3A. (1215 aa)
ENSXCOP00000008263Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (760 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
ENSXCOP00000008401Retinoblastoma-like 2 (p130). (774 aa)
ENSXCOP00000008470RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1114 aa)
ENSXCOP00000008629Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (568 aa)
ENSXCOP00000008872DNA polymerase. (1344 aa)
ENSXCOP00000008968Wee1-like protein kinase. (526 aa)
ENSXCOP00000009602Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (435 aa)
LOC114147096Proteasome subunit beta. (271 aa)
ENSXCOP00000010411Origin recognition complex, subunit 2. (391 aa)
ENSXCOP00000010446DNA helicase; Belongs to the MCM family. (662 aa)
ppp2r1bProtein phosphatase 2, regulatory subunit A, beta b. (589 aa)
Mcm2DNA helicase; Belongs to the MCM family. (902 aa)
ENSXCOP00000010985V-akt murine thymoma viral oncogene homolog 3b; Belongs to the protein kinase superfamily. (498 aa)
ENSXCOP00000011040Cyclin-dependent kinase inhibitor 1Cb. (219 aa)
Psmc1Proteasome 26S subunit, ATPase 1b. (257 aa)
ENSXCOP00000011179Proteasome subunit alpha type. (233 aa)
Mnat1MNAT1 component of CDK activating kinase. (302 aa)
LOC114138792Serine/threonine-protein phosphatase. (309 aa)
ENSXCOP00000012493DNA helicase; Belongs to the MCM family. (757 aa)
ENSXCOP00000012623Tyrosine-protein kinase. (1119 aa)
ENSXCOP00000012693Proteasome 26S subunit, non-ATPase 13. (357 aa)
ENSXCOP00000012819Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B. (703 aa)
ENSXCOP00000013093Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (554 aa)
ENSXCOP00000013308Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (589 aa)
Ccna1Cyclin A1; Belongs to the cyclin family. (397 aa)
LOC114150313Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
Wee1Wee1-like protein kinase. (620 aa)
ENSXCOP00000028006Cyclin-dependent kinase inhibitor 1Bb. (176 aa)
Psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (401 aa)
ENSXCOP00000027383KxDL motif containing 1. (193 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (330 aa)
ENSXCOP00000013704Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (432 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
ENSXCOP00000013978Proteasome 26S subunit, non-ATPase 11a. (420 aa)
ENSXCOP00000014070Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b. (685 aa)
ENSXCOP00000014165SCY domain-containing protein. (122 aa)
Pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (145 aa)
Cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (141 aa)
Lin52Lin-52 DREAM MuvB core complex component. (116 aa)
ENSXCOP00000014609Proteasome subunit beta 8A. (160 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (442 aa)
Psmd10ANK_REP_REGION domain-containing protein. (73 aa)
cdkn2bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)
ENSXCOP00000015019Uncharacterized protein. (423 aa)
Psmb3Proteasome subunit beta. (204 aa)
ENSXCOP00000015223E2F_TDP domain-containing protein. (184 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
ENSXCOP00000015546Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (683 aa)
Prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (499 aa)
Psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (421 aa)
Psmb1Proteasome subunit beta. (240 aa)
ENSXCOP00000016598Serine/threonine-protein phosphatase. (300 aa)
Psmb6Proteasome subunit beta 6. (251 aa)
ENSXCOP00000018797Proteasome subunit beta 12. (192 aa)
ENSXCOP00000018793Proteasome subunit beta 13a. (218 aa)
ENSXCOP00000018558Peptidase_S39 domain-containing protein. (152 aa)
Psma6Proteasome subunit alpha type. (252 aa)
LOC114160881Cyclin D2, b; Belongs to the cyclin family. (294 aa)
Cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (178 aa)
ENSXCOP00000017654Protein kinase domain-containing protein. (75 aa)
ENSXCOP00000017651V-akt murine thymoma viral oncogene homolog 3a. (162 aa)
Ppp2r3cProtein phosphatase 2, regulatory subunit B'', gamma. (439 aa)
gmnnGeminin DNA replication inhibitor. (216 aa)
ENSXCOP00000026541Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (63 aa)
ENSXCOP00000026291E2F_TDP domain-containing protein. (273 aa)
ENSXCOP00000026249DBF4 zinc finger. (527 aa)
ENSXCOP00000026215Proteasome 26S subunit, non-ATPase 4b. (350 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
psmb2Proteasome subunit beta. (199 aa)
Tfdp1Transcription factor. (401 aa)
PPP2R3BEF-hand domain-containing protein. (531 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (316 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (264 aa)
psma5Proteasome subunit alpha type. (241 aa)
ENSXCOP00000024324Proteasome 26S subunit, non-ATPase 3. (462 aa)
Your Current Organism:
Xiphophorus couchianus
NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus
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