(38 nodes) Downstream signaling of activated FGFR1 network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CSDE1	Cold shock domain containing E1, RNA-binding. (605 aa)
	Grb2	Growth factor receptor-bound protein 2b. (210 aa)
	ENSXCOP00000002045	Fibronectin leucine rich transmembrane protein 1b. (672 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (177 aa)
	ENSXCOP00000006639	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	ENSXCOP00000007475	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (68 aa)
	FLRT1	Fibronectin leucine rich transmembrane protein 1. (681 aa)
	fgf1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
	ENSXCOP00000009526	PH domain-containing protein. (389 aa)
	flrt3	Fibronectin leucine rich transmembrane 3. (650 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	ENSXCOP00000010603	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
	ENSXCOP00000010846	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (944 aa)
	ENSXCOP00000010848	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (128 aa)
	ENSXCOP00000011255	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (149 aa)
	Fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	ENSXCOP00000011650	Fibroblast growth factor receptor substrate 3. (605 aa)
	LOC114150449	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	LOC114134660	Fibronectin leucine rich transmembrane protein 2. (651 aa)
	ENSXCOP00000012424	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (189 aa)
	ENSXCOP00000012523	Uncharacterized protein. (69 aa)
	ENSXCOP00000014719	GRB2-associated binding protein 1. (697 aa)
	LOC114139226	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	ENSXCOP00000018291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (68 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	ENSXCOP00000018718	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	ENSXCOP00000019691	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	ENSXCOP00000020409	Receptor protein-tyrosine kinase. (417 aa)
	Fgfr1	Protein kinase domain-containing protein. (301 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	Fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
	LOC114160036	Zgc:55558. (187 aa)
	ENSXCOP00000026173	SHC (Src homology 2 domain containing) transforming protein 1. (459 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)
	ENSXCOP00000027869	Fibroblast growth factor receptor substrate 2b. (498 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSXCOP00000010846	ENSXCOP00000000038	ENSXCOP00000010846	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.526
CSDE1	ENSXCOP00000010848	ENSXCOP00000000038	ENSXCOP00000010848	Cold shock domain containing E1, RNA-binding.	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.526
CSDE1	ENSXCOP00000011650	ENSXCOP00000000038	ENSXCOP00000011650	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.429
CSDE1	ENSXCOP00000018718	ENSXCOP00000000038	ENSXCOP00000018718	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.420
CSDE1	ENSXCOP00000026173	ENSXCOP00000000038	ENSXCOP00000026173	Cold shock domain containing E1, RNA-binding.	SHC (Src homology 2 domain containing) transforming protein 1.	0.442
CSDE1	ENSXCOP00000027869	ENSXCOP00000000038	ENSXCOP00000027869	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.429
CSDE1	Fgf17	ENSXCOP00000000038	ENSXCOP00000011438	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
CSDE1	Fgf3	ENSXCOP00000000038	ENSXCOP00000023728	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.442
CSDE1	Grb2	ENSXCOP00000000038	ENSXCOP00000000623	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.666
CSDE1	PIK3CA	ENSXCOP00000000038	ENSXCOP00000009802	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.526
CSDE1	fgf23	ENSXCOP00000000038	ENSXCOP00000018293	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.417
CSDE1	fgf5	ENSXCOP00000000038	ENSXCOP00000010839	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.403
ENSXCOP00000002045	ENSXCOP00000018718	ENSXCOP00000002045	ENSXCOP00000018718	Fibronectin leucine rich transmembrane protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.435
ENSXCOP00000002045	Fgf17	ENSXCOP00000002045	ENSXCOP00000011438	Fibronectin leucine rich transmembrane protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.451
ENSXCOP00000002045	Fgf3	ENSXCOP00000002045	ENSXCOP00000023728	Fibronectin leucine rich transmembrane protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.451
ENSXCOP00000002045	fgf23	ENSXCOP00000002045	ENSXCOP00000018293	Fibronectin leucine rich transmembrane protein 1b.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.451
ENSXCOP00000002045	fgf5	ENSXCOP00000002045	ENSXCOP00000010839	Fibronectin leucine rich transmembrane protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.401
ENSXCOP00000006639	ENSXCOP00000011255	ENSXCOP00000006639	ENSXCOP00000011255	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.488
ENSXCOP00000006639	ENSXCOP00000018718	ENSXCOP00000006639	ENSXCOP00000018718	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.521
ENSXCOP00000006639	ENSXCOP00000020409	ENSXCOP00000006639	ENSXCOP00000020409	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Receptor protein-tyrosine kinase.	0.498