(23 nodes) FRS-mediated FGFR4 signaling network (Xiphophorus couchianus)

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Your Input:
	ENSXCOP00000027869	Fibroblast growth factor receptor substrate 2b. (498 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (605 aa)
	Grb2	Growth factor receptor-bound protein 2b. (210 aa)
	Fgf18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (177 aa)
	Fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	ENSXCOP00000007475	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (68 aa)
	fgf1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
	ENSXCOP00000011255	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (149 aa)
	Fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	ENSXCOP00000011650	Fibroblast growth factor receptor substrate 3. (605 aa)
	ENSXCOP00000012523	Uncharacterized protein. (69 aa)
	LOC114139226	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	ENSXCOP00000018291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (68 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	ENSXCOP00000018718	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	ENSXCOP00000019691	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	Fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (199 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	LOC114160036	Zgc:55558. (187 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSXCOP00000011650	ENSXCOP00000000038	ENSXCOP00000011650	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.429
CSDE1	ENSXCOP00000018718	ENSXCOP00000000038	ENSXCOP00000018718	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.420
CSDE1	ENSXCOP00000027869	ENSXCOP00000000038	ENSXCOP00000027869	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.429
CSDE1	Fgf17	ENSXCOP00000000038	ENSXCOP00000011438	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
CSDE1	Fgf18	ENSXCOP00000000038	ENSXCOP00000003848	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.517
CSDE1	Grb2	ENSXCOP00000000038	ENSXCOP00000000623	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.666
CSDE1	fgf23	ENSXCOP00000000038	ENSXCOP00000018293	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.417
ENSXCOP00000007475	Fgf19	ENSXCOP00000007475	ENSXCOP00000023717	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.447
ENSXCOP00000007475	Grb2	ENSXCOP00000007475	ENSXCOP00000000623	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.441
ENSXCOP00000007475	fgf23	ENSXCOP00000007475	ENSXCOP00000018293	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.514
ENSXCOP00000011255	ENSXCOP00000011650	ENSXCOP00000011255	ENSXCOP00000011650	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor substrate 3.	0.423
ENSXCOP00000011255	ENSXCOP00000012523	ENSXCOP00000011255	ENSXCOP00000012523	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Uncharacterized protein.	0.407
ENSXCOP00000011255	ENSXCOP00000018718	ENSXCOP00000011255	ENSXCOP00000018718	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.569
ENSXCOP00000011255	ENSXCOP00000027869	ENSXCOP00000011255	ENSXCOP00000027869	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor substrate 2b.	0.423
ENSXCOP00000011255	FGF4	ENSXCOP00000011255	ENSXCOP00000004415	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.457
ENSXCOP00000011255	Fgf17	ENSXCOP00000011255	ENSXCOP00000011438	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.615
ENSXCOP00000011255	Fgf18	ENSXCOP00000011255	ENSXCOP00000003848	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.555
ENSXCOP00000011255	Fgf19	ENSXCOP00000011255	ENSXCOP00000023717	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.463
ENSXCOP00000011255	Grb2	ENSXCOP00000011255	ENSXCOP00000000623	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Growth factor receptor-bound protein 2b.	0.531
ENSXCOP00000011255	fgf23	ENSXCOP00000011255	ENSXCOP00000018293	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.561