39 items (Xiphophorus couchianus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	ENSXCOP00000018291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (68 aa)
	ENSXCOP00000016904	Cbl proto-oncogene, E3 ubiquitin protein ligase. (903 aa)
	ENSXCOP00000016598	Serine/threonine-protein phosphatase. (300 aa)
	LOC114139226	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	Mapk1	Mitogen-activated protein kinase. (357 aa)
	ENSXCOP00000013233	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (409 aa)
	ENSXCOP00000012523	Uncharacterized protein. (69 aa)
	Mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (427 aa)
	Fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC114138792	Serine/threonine-protein phosphatase. (309 aa)
	ENSXCOP00000011255	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (149 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	Cblc	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (507 aa)
	ENSXCOP00000008291	Sprouty homolog 4 (Drosophila). (289 aa)
	fgf1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
	Fndc3a	Fibronectin type III domain containing 3A. (1215 aa)
	ENSXCOP00000007475	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (68 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	Fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	Ppp2ca	Serine/threonine-protein phosphatase. (221 aa)
	Grb2	Growth factor receptor-bound protein 2b. (210 aa)
	ENSXCOP00000027869	Fibroblast growth factor receptor substrate 2b. (498 aa)
	LOC114138068	Ribosomal protein S27a. (156 aa)
	LOC114140865	Tyrosine-protein kinase. (527 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	ENSXCOP00000024246	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (407 aa)
	ENSXCOP00000024891	UBA domain-containing protein. (130 aa)
	CBL	Uncharacterized protein. (479 aa)
	Fgf18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (177 aa)
	Fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (199 aa)
	Spry2	Sprouty RTK signaling antagonist 2. (354 aa)
	LOC114149001	Ubiquitin-like domain-containing protein. (77 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ENSXCOP00000019691	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	Fndc3b	Fibronectin type III domain containing 3Ba. (1174 aa)
	ENSXCOP00000018718	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	Cblc	ENSXCOP00000024893	ENSXCOP00000010328	Uncharacterized protein.	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.902
CBL	ENSXCOP00000008291	ENSXCOP00000024893	ENSXCOP00000008291	Uncharacterized protein.	Sprouty homolog 4 (Drosophila).	0.785
CBL	ENSXCOP00000011255	ENSXCOP00000024893	ENSXCOP00000011255	Uncharacterized protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.418
CBL	ENSXCOP00000018718	ENSXCOP00000024893	ENSXCOP00000018718	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CBL	ENSXCOP00000024891	ENSXCOP00000024893	ENSXCOP00000024891	Uncharacterized protein.	UBA domain-containing protein.	0.693
CBL	ENSXCOP00000027869	ENSXCOP00000024893	ENSXCOP00000027869	Uncharacterized protein.	Fibroblast growth factor receptor substrate 2b.	0.533
CBL	Fgf17	ENSXCOP00000024893	ENSXCOP00000011438	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
CBL	Fgf18	ENSXCOP00000024893	ENSXCOP00000003848	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.452
CBL	Fgf19	ENSXCOP00000024893	ENSXCOP00000023717	Uncharacterized protein.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.510
CBL	Grb2	ENSXCOP00000024893	ENSXCOP00000000623	Uncharacterized protein.	Growth factor receptor-bound protein 2b.	0.912
CBL	LOC114138068	ENSXCOP00000024893	ENSXCOP00000004814	Uncharacterized protein.	Ribosomal protein S27a.	0.753
CBL	LOC114140865	ENSXCOP00000024893	ENSXCOP00000000604	Uncharacterized protein.	Tyrosine-protein kinase.	0.485
CBL	LOC114149001	ENSXCOP00000024893	ENSXCOP00000023106	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.605
CBL	SRC	ENSXCOP00000024893	ENSXCOP00000021988	Uncharacterized protein.	Tyrosine-protein kinase.	0.485
CBL	Spry2	ENSXCOP00000024893	ENSXCOP00000023455	Uncharacterized protein.	Sprouty RTK signaling antagonist 2.	0.868
CBL	fgf1	ENSXCOP00000024893	ENSXCOP00000008287	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.572
CBL	fgf23	ENSXCOP00000024893	ENSXCOP00000018293	Uncharacterized protein.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.444
CBL	ppp2r1b	ENSXCOP00000024893	ENSXCOP00000010554	Uncharacterized protein.	Protein phosphatase 2, regulatory subunit A, beta b.	0.429
CBL	uba52	ENSXCOP00000024893	ENSXCOP00000007438	Uncharacterized protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.605
Cblc	CBL	ENSXCOP00000010328	ENSXCOP00000024893	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	Uncharacterized protein.	0.902