35 items (Xiphophorus couchianus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC114143405	RING-type domain-containing protein. (361 aa)
	ENSXCOP00000027383	KxDL motif containing 1. (193 aa)
	OTUD7A	OTU deubiquitinase 7A. (801 aa)
	ENSXCOP00000000583	Uncharacterized protein. (333 aa)
	ENSXCOP00000000856	Homeobox domain-containing protein. (128 aa)
	ENSXCOP00000001113	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (445 aa)
	ENSXCOP00000001240	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (400 aa)
	Tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (332 aa)
	ENSXCOP00000003313	OTU deubiquitinase 3. (334 aa)
	rnf13	Ring finger protein 13. (377 aa)
	LOC114138068	Ribosomal protein S27a. (156 aa)
	Esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (614 aa)
	ENSXCOP00000006117	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (581 aa)
	Zranb1	Uncharacterized protein. (342 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	Cskmt	Methyltransf_25 domain-containing protein. (221 aa)
	Otub1	OTU deubiquitinase, ubiquitin aldehyde binding 1b. (259 aa)
	ENSXCOP00000009536	APC regulator of WNT signaling pathway 2. (1466 aa)
	ENSXCOP00000009735	Receptor-interacting serine-threonine kinase 2. (575 aa)
	ENSXCOP00000010718	Ring finger protein 167. (404 aa)
	GUF1	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (562 aa)
	ENSXCOP00000012124	TNFAIP3 interacting protein 1. (634 aa)
	ENSXCOP00000013029	Zinc finger, RAN-binding domain containing 1b. (741 aa)
	Tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (800 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	Cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (224 aa)
	ENSXCOP00000019342	Zgc:136908; Belongs to the AAA ATPase family. (725 aa)
	ENSXCOP00000019983	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (668 aa)
	SPATA5	Spermatogenesis associated 5; Belongs to the AAA ATPase family. (684 aa)
	yod1	YOD1 deubiquitinase. (300 aa)
	Vcpip1	OTU domain-containing protein. (1192 aa)
	ENSXCOP00000022549	OTU deubiquitinase 5a. (330 aa)
	Vcp	Valosin containing protein; Belongs to the AAA ATPase family. (761 aa)
	Nod1	Nucleotide-binding oligomerization domain containing 1. (912 aa)
	LOC114149001	Ubiquitin-like domain-containing protein. (77 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdk1	LOC114138068	ENSXCOP00000018783	ENSXCOP00000004814	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Ribosomal protein S27a.	0.658
Cdk1	LOC114149001	ENSXCOP00000018783	ENSXCOP00000023106	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Ubiquitin-like domain-containing protein.	0.559
Cdk1	Tp53	ENSXCOP00000018783	ENSXCOP00000002276	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.698
Cdk1	Vcpip1	ENSXCOP00000018783	ENSXCOP00000022165	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	OTU domain-containing protein.	0.538
Cdk1	uba52	ENSXCOP00000018783	ENSXCOP00000007438	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.559
Cskmt	ENSXCOP00000010718	ENSXCOP00000007456	ENSXCOP00000010718	Methyltransf_25 domain-containing protein.	Ring finger protein 167.	0.527
Cskmt	LOC114138068	ENSXCOP00000007456	ENSXCOP00000004814	Methyltransf_25 domain-containing protein.	Ribosomal protein S27a.	0.843
Cskmt	LOC114143405	ENSXCOP00000007456	ENSXCOP00000024647	Methyltransf_25 domain-containing protein.	RING-type domain-containing protein.	0.527
Cskmt	LOC114149001	ENSXCOP00000007456	ENSXCOP00000023106	Methyltransf_25 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.748
Cskmt	Tp53	ENSXCOP00000007456	ENSXCOP00000002276	Methyltransf_25 domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.438
Cskmt	rnf13	ENSXCOP00000007456	ENSXCOP00000004247	Methyltransf_25 domain-containing protein.	Ring finger protein 13.	0.527
Cskmt	uba52	ENSXCOP00000007456	ENSXCOP00000007438	Methyltransf_25 domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.748
ENSXCOP00000000583	ENSXCOP00000013029	ENSXCOP00000000583	ENSXCOP00000013029	Uncharacterized protein.	Zinc finger, RAN-binding domain containing 1b.	0.572
ENSXCOP00000000583	OTUD7A	ENSXCOP00000000583	ENSXCOP00000026876	Uncharacterized protein.	OTU deubiquitinase 7A.	0.472
ENSXCOP00000000583	Tnfaip3	ENSXCOP00000000583	ENSXCOP00000017665	Uncharacterized protein.	Tumor necrosis factor, alpha-induced protein 3.	0.472
ENSXCOP00000000583	Vcpip1	ENSXCOP00000000583	ENSXCOP00000022165	Uncharacterized protein.	OTU domain-containing protein.	0.472
ENSXCOP00000000583	Zranb1	ENSXCOP00000000583	ENSXCOP00000007319	Uncharacterized protein.	Uncharacterized protein.	0.572
ENSXCOP00000001113	ENSXCOP00000003313	ENSXCOP00000001113	ENSXCOP00000003313	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	OTU deubiquitinase 3.	0.638
ENSXCOP00000001113	GUF1	ENSXCOP00000001113	ENSXCOP00000011676	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.	0.411
ENSXCOP00000001113	LOC114138068	ENSXCOP00000001113	ENSXCOP00000004814	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	Ribosomal protein S27a.	0.561