24 items (Xiphophorus couchianus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC114149001	Ubiquitin-like domain-containing protein. (77 aa)
	ENSXCOP00000000335	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2879 aa)
	ENSXCOP00000001295	Lysine methyltransferase 5Ab. (257 aa)
	ENSXCOP00000001751	Uncharacterized protein. (60 aa)
	Tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (332 aa)
	ENSXCOP00000003755	Uncharacterized protein. (116 aa)
	ENSXCOP00000004077	L3MBTL histone methyl-lysine binding protein 1a. (507 aa)
	Smyd2	SET and MYND domain containing 2b. (431 aa)
	ENSXCOP00000007055	Uncharacterized protein. (520 aa)
	ENSXCOP00000007056	ANK_REP_REGION domain-containing protein. (117 aa)
	ENSXCOP00000007059	SET domain-containing protein. (158 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	Setd9	SET domain containing 9. (278 aa)
	Prmt5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (593 aa)
	ENSXCOP00000011485	ANK_REP_REGION domain-containing protein. (97 aa)
	ENSXCOP00000011491	SET domain-containing protein. (162 aa)
	Kmt5a	Lysine methyltransferase 5Aa. (227 aa)
	ENSXCOP00000015358	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (454 aa)
	ENSXCOP00000016575	Checkpoint kinase 2. (499 aa)
	ENSXCOP00000018903	E1A binding protein p300 b. (2516 aa)
	JMY	Junction mediating and regulatory protein, p53 cofactor. (822 aa)
	ENSXCOP00000026118	Uncharacterized protein. (314 aa)
	ENSXCOP00000026286	L3MBTL histone methyl-lysine binding protein 1b. (724 aa)
	ENSXCOP00000027383	KxDL motif containing 1. (193 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXCOP00000000335	ENSXCOP00000015358	ENSXCOP00000000335	ENSXCOP00000015358	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.918
ENSXCOP00000000335	ENSXCOP00000016575	ENSXCOP00000000335	ENSXCOP00000016575	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Checkpoint kinase 2.	0.972
ENSXCOP00000000335	ENSXCOP00000018903	ENSXCOP00000000335	ENSXCOP00000018903	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	E1A binding protein p300 b.	0.534
ENSXCOP00000000335	Tp53	ENSXCOP00000000335	ENSXCOP00000002276	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.980
ENSXCOP00000001295	Tp53	ENSXCOP00000001295	ENSXCOP00000002276	Lysine methyltransferase 5Ab.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.722
ENSXCOP00000001751	Tp53	ENSXCOP00000001751	ENSXCOP00000002276	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.910
ENSXCOP00000003755	Tp53	ENSXCOP00000003755	ENSXCOP00000002276	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.652
ENSXCOP00000004077	Tp53	ENSXCOP00000004077	ENSXCOP00000002276	L3MBTL histone methyl-lysine binding protein 1a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.652
ENSXCOP00000007055	ENSXCOP00000007059	ENSXCOP00000007055	ENSXCOP00000007059	Uncharacterized protein.	SET domain-containing protein.	0.894
ENSXCOP00000007055	ENSXCOP00000011491	ENSXCOP00000007055	ENSXCOP00000011491	Uncharacterized protein.	SET domain-containing protein.	0.862
ENSXCOP00000007055	ENSXCOP00000026118	ENSXCOP00000007055	ENSXCOP00000026118	Uncharacterized protein.	Uncharacterized protein.	0.636
ENSXCOP00000007055	LOC114149001	ENSXCOP00000007055	ENSXCOP00000023106	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.511
ENSXCOP00000007055	Tp53	ENSXCOP00000007055	ENSXCOP00000002276	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.607
ENSXCOP00000007055	uba52	ENSXCOP00000007055	ENSXCOP00000007438	Uncharacterized protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.511
ENSXCOP00000007056	ENSXCOP00000007059	ENSXCOP00000007056	ENSXCOP00000007059	ANK_REP_REGION domain-containing protein.	SET domain-containing protein.	0.898
ENSXCOP00000007056	ENSXCOP00000011491	ENSXCOP00000007056	ENSXCOP00000011491	ANK_REP_REGION domain-containing protein.	SET domain-containing protein.	0.898
ENSXCOP00000007056	ENSXCOP00000026118	ENSXCOP00000007056	ENSXCOP00000026118	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.899
ENSXCOP00000007056	LOC114149001	ENSXCOP00000007056	ENSXCOP00000023106	ANK_REP_REGION domain-containing protein.	Ubiquitin-like domain-containing protein.	0.511
ENSXCOP00000007056	Tp53	ENSXCOP00000007056	ENSXCOP00000002276	ANK_REP_REGION domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.607
ENSXCOP00000007056	uba52	ENSXCOP00000007056	ENSXCOP00000007438	ANK_REP_REGION domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.511