(69 nodes) Signaling by PTK6 network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXCOP00000024722	Engulfment and cell motility 2. (667 aa)
	ENSXCOP00000028006	Cyclin-dependent kinase inhibitor 1Bb. (176 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	ENSXCOP00000027383	KxDL motif containing 1. (193 aa)
	ENSXCOP00000027374	Erb-b2 receptor tyrosine kinase 4a. (725 aa)
	ENSXCOP00000027049	EGF-like domain-containing protein. (96 aa)
	elmo1	Engulfment and cell motility 1. (726 aa)
	ENSXCOP00000026651	Protein kinase domain-containing protein. (514 aa)
	ENSXCOP00000026650	Uncharacterized protein. (97 aa)
	ENSXCOP00000025236	ELMO/CED-12 domain containing 1. (308 aa)
	CBL	Uncharacterized protein. (479 aa)
	ENSXCOP00000024891	UBA domain-containing protein. (130 aa)
	Cdk4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (316 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (264 aa)
	LOC114160036	Zgc:55558. (187 aa)
	Ccne1	Cyclin E1; Belongs to the cyclin family. (284 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	ENSXCOP00000023584	Uncharacterized protein. (204 aa)
	ENSXCOP00000023583	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (519 aa)
	ENSXCOP00000023350	Paraspeckle component 1. (423 aa)
	LOC114149001	Ubiquitin-like domain-containing protein. (77 aa)
	Nrg2	Neuregulin 2a. (697 aa)
	ENSXCOP00000022826	Neuregulin domain-containing protein. (554 aa)
	ENSXCOP00000022524	Tyrosine-protein kinase. (440 aa)
	ENSXCOP00000022519	Tyrosine-protein kinase. (499 aa)
	ENSXCOP00000022345	RAS p21 protein activator (GTPase activating protein) 1a. (983 aa)
	Egfr	Receptor protein-tyrosine kinase. (1206 aa)
	ENSXCOP00000020834	ELMO/CED-12 domain containing 3. (285 aa)
	nono	Non-POU domain containing, octamer-binding. (439 aa)
	ENSXCOP00000019096	Tyrosine-protein phosphatase non-receptor type. (427 aa)
	ENSXCOP00000018748	Uncharacterized protein. (299 aa)
	ENSXCOP00000018489	Receptor protein-tyrosine kinase. (1093 aa)
	Sfpq	RRM domain-containing protein. (140 aa)
	ENSXCOP00000017654	Protein kinase domain-containing protein. (75 aa)
	ENSXCOP00000017651	V-akt murine thymoma viral oncogene homolog 3a. (162 aa)
	ENSXCOP00000017197	C2H2-type domain-containing protein. (389 aa)
	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (668 aa)
	ENSXCOP00000017026	Arf-GAP domain-containing protein. (106 aa)
	ENSXCOP00000016923	Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family. (209 aa)
	ENSXCOP00000016904	Cbl proto-oncogene, E3 ubiquitin protein ligase. (903 aa)
	Arhgap35	Uncharacterized protein. (1483 aa)
	ENSXCOP00000016659	Neuregulin 2b. (620 aa)
	ENSXCOP00000015694	KH domain containing, RNA binding, signal transduction associated 2. (279 aa)
	ENSXCOP00000014541	KH domain containing, RNA binding, signal transduction associated 1a. (337 aa)
	ENSXCOP00000014127	Suppressor of cytokine signaling 3a. (232 aa)
	KHDRBS3	KH RNA binding domain containing, signal transduction associated 3. (291 aa)
	ENSXCOP00000012555	EGF-like domain-containing protein. (132 aa)
	LOC114139518	Heparin-binding EGF-like growth factor a. (236 aa)
	ENSXCOP00000010985	V-akt murine thymoma viral oncogene homolog 3b; Belongs to the protein kinase superfamily. (498 aa)
	ENSXCOP00000010807	Signal transducing adaptor family member 2a. (337 aa)
	ENSXCOP00000010389	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (545 aa)
	Cblc	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (507 aa)
	ENSXCOP00000009302	Uncharacterized protein. (113 aa)
	ENSXCOP00000009040	Erb-b2 receptor tyrosine kinase 3b. (1180 aa)
	LOC114153331	Rho GTPase activating protein 35b. (1529 aa)
	ENSXCOP00000008173	Uncharacterized protein. (89 aa)
	ENSXCOP00000007663	Suppressor of cytokine signaling 3. (218 aa)
	ENSXCOP00000007578	Engulfment and cell motility 3. (442 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	ENSXCOP00000007242	ANK_REP_REGION domain-containing protein. (1137 aa)
	ENSXCOP00000006903	Docking protein 1b. (584 aa)
	CRK	CRK proto-oncogene, adaptor protein. (315 aa)
	LOC114138068	Ribosomal protein S27a. (156 aa)
	ENSXCOP00000004522	Qua1 domain-containing protein. (87 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (466 aa)
	Erbb2	Uncharacterized protein. (268 aa)
	ENSXCOP00000001154	Receptor protein-tyrosine kinase. (610 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (605 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARAP1	ENSXCOP00000017026	ENSXCOP00000017027	ENSXCOP00000017026	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	Arf-GAP domain-containing protein.	0.905
Arhgap35	ENSXCOP00000022345	ENSXCOP00000016800	ENSXCOP00000022345	Uncharacterized protein.	RAS p21 protein activator (GTPase activating protein) 1a.	0.840
Arhgap35	ENSXCOP00000022519	ENSXCOP00000016800	ENSXCOP00000022519	Uncharacterized protein.	Tyrosine-protein kinase.	0.405
Arhgap35	ENSXCOP00000022524	ENSXCOP00000016800	ENSXCOP00000022524	Uncharacterized protein.	Tyrosine-protein kinase.	0.405
Arhgap35	LOC114153331	ENSXCOP00000016800	ENSXCOP00000008183	Uncharacterized protein.	Rho GTPase activating protein 35b.	0.901
CBL	CRK	ENSXCOP00000024893	ENSXCOP00000005850	Uncharacterized protein.	CRK proto-oncogene, adaptor protein.	0.786
CBL	Cblc	ENSXCOP00000024893	ENSXCOP00000010328	Uncharacterized protein.	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.902
CBL	ENSXCOP00000001154	ENSXCOP00000024893	ENSXCOP00000001154	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.604
CBL	ENSXCOP00000009040	ENSXCOP00000024893	ENSXCOP00000009040	Uncharacterized protein.	Erb-b2 receptor tyrosine kinase 3b.	0.604
CBL	ENSXCOP00000009302	ENSXCOP00000024893	ENSXCOP00000009302	Uncharacterized protein.	Uncharacterized protein.	0.604
CBL	ENSXCOP00000012555	ENSXCOP00000024893	ENSXCOP00000012555	Uncharacterized protein.	EGF-like domain-containing protein.	0.436
CBL	ENSXCOP00000017197	ENSXCOP00000024893	ENSXCOP00000017197	Uncharacterized protein.	C2H2-type domain-containing protein.	0.604
CBL	ENSXCOP00000018489	ENSXCOP00000024893	ENSXCOP00000018489	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.604
CBL	ENSXCOP00000022519	ENSXCOP00000024893	ENSXCOP00000022519	Uncharacterized protein.	Tyrosine-protein kinase.	0.544
CBL	ENSXCOP00000022524	ENSXCOP00000024893	ENSXCOP00000022524	Uncharacterized protein.	Tyrosine-protein kinase.	0.544
CBL	ENSXCOP00000024891	ENSXCOP00000024893	ENSXCOP00000024891	Uncharacterized protein.	UBA domain-containing protein.	0.693
CBL	ENSXCOP00000026650	ENSXCOP00000024893	ENSXCOP00000026650	Uncharacterized protein.	Uncharacterized protein.	0.604
CBL	ENSXCOP00000026651	ENSXCOP00000024893	ENSXCOP00000026651	Uncharacterized protein.	Protein kinase domain-containing protein.	0.604
CBL	ENSXCOP00000027374	ENSXCOP00000024893	ENSXCOP00000027374	Uncharacterized protein.	Erb-b2 receptor tyrosine kinase 4a.	0.604
CBL	Egfr	ENSXCOP00000024893	ENSXCOP00000021790	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.958