(48 nodes) Mitophagy - animal network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC114140865	Tyrosine-protein kinase. (527 aa)
	LOC114142078	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
	ENSXCOP00000001319	Zgc:86598; Belongs to the protein kinase superfamily. (336 aa)
	GABARAPL2	GABA type A receptor associated protein like 2. (122 aa)
	ENSXCOP00000001533	Mitogen-activated protein kinase. (420 aa)
	LOC114149301	Zgc:73226. (182 aa)
	Tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (332 aa)
	Mfn2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (737 aa)
	Gabarap	GABA(A) receptor-associated protein b. (144 aa)
	Mapk10	Mitogen-activated protein kinase. (384 aa)
	ENSXCOP00000003227	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (332 aa)
	Mfn1	Mitofusin 1b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (657 aa)
	LOC114134723	Fork-head domain-containing protein. (604 aa)
	LOC114139131	Mitogen-activated protein kinase. (420 aa)
	ENSXCOP00000004360	Fork-head domain-containing protein. (241 aa)
	Calcoco2	SKICH domain-containing protein. (155 aa)
	LOC114138068	Ribosomal protein S27a. (156 aa)
	foxo3	Forkhead box O3b. (659 aa)
	Eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1018 aa)
	LOC114149929	BCL2 interacting protein 3 like b. (221 aa)
	LOC114157395	V-rel avian reticuloendotheliosis viral oncogene homolog A. (628 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	Becn1	Beclin 1, autophagy related. (439 aa)
	LOC114147892	RAS related. (197 aa)
	Jun	BZIP domain-containing protein; Belongs to the bZIP family. (329 aa)
	bnip3	BCL2 interacting protein 3. (191 aa)
	Rhot2	Ras homolog family member T2. (499 aa)
	Tfe3	Transcription factor binding to IGHM enhancer 3b. (442 aa)
	Tbk1	Protein kinase domain-containing protein. (134 aa)
	ENSXCOP00000015874	Mitogen-activated protein kinase. (384 aa)
	Atg9a	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (835 aa)
	MRAS	Muscle RAS oncogene homolog. (132 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	Usp15	USP domain-containing protein; Belongs to the peptidase C19 family. (175 aa)
	ENSXCOP00000020196	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (742 aa)
	pgam5	PGAM family member 5, serine/threonine protein phosphatase, mitochondrial. (297 aa)
	ENSXCOP00000021206	Activating transcription factor 4a. (426 aa)
	Ambra1	Autophagy/beclin-1 regulator 1b. (1303 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	BCL2L1	BCL2 like 1. (219 aa)
	FUNDC1	FUN14 domain containing 1. (173 aa)
	LOC114135099	Si:dkey-13a21.4. (204 aa)
	Fundc1	Uncharacterized protein. (153 aa)
	LOC114160036	Zgc:55558. (187 aa)
	Tfeb	Transcription factor EB. (513 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ambra1	Becn1	ENSXCOP00000021310	ENSXCOP00000008229	Autophagy/beclin-1 regulator 1b.	Beclin 1, autophagy related.	0.991
Ambra1	FUNDC1	ENSXCOP00000021310	ENSXCOP00000023519	Autophagy/beclin-1 regulator 1b.	FUN14 domain containing 1.	0.408
Ambra1	Fundc1	ENSXCOP00000021310	ENSXCOP00000024124	Autophagy/beclin-1 regulator 1b.	Uncharacterized protein.	0.408
Atg9a	Becn1	ENSXCOP00000018744	ENSXCOP00000008229	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Beclin 1, autophagy related.	0.836
Atg9a	ENSXCOP00000020196	ENSXCOP00000018744	ENSXCOP00000020196	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.902
Atg9a	GABARAPL2	ENSXCOP00000018744	ENSXCOP00000001415	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	GABA type A receptor associated protein like 2.	0.476
Atg9a	Gabarap	ENSXCOP00000018744	ENSXCOP00000002948	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	GABA(A) receptor-associated protein b.	0.476
Atg9a	pink1	ENSXCOP00000018744	ENSXCOP00000019270	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	PTEN induced kinase 1.	0.437
BCL2L1	Becn1	ENSXCOP00000023518	ENSXCOP00000008229	BCL2 like 1.	Beclin 1, autophagy related.	0.995
BCL2L1	ENSXCOP00000001533	ENSXCOP00000023518	ENSXCOP00000001533	BCL2 like 1.	Mitogen-activated protein kinase.	0.933
BCL2L1	ENSXCOP00000015874	ENSXCOP00000023518	ENSXCOP00000015874	BCL2 like 1.	Mitogen-activated protein kinase.	0.933
BCL2L1	Hras	ENSXCOP00000023518	ENSXCOP00000027630	BCL2 like 1.	HRas proto-oncogene, GTPase a.	0.583
BCL2L1	KRAS	ENSXCOP00000023518	ENSXCOP00000027471	BCL2 like 1.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.583
BCL2L1	LOC114139131	ENSXCOP00000023518	ENSXCOP00000004298	BCL2 like 1.	Mitogen-activated protein kinase.	0.928
BCL2L1	LOC114149301	ENSXCOP00000023518	ENSXCOP00000002089	BCL2 like 1.	Zgc:73226.	0.937
BCL2L1	LOC114149929	ENSXCOP00000023518	ENSXCOP00000006965	BCL2 like 1.	BCL2 interacting protein 3 like b.	0.579
BCL2L1	LOC114160036	ENSXCOP00000023518	ENSXCOP00000024372	BCL2 like 1.	Zgc:55558.	0.583
BCL2L1	Mapk10	ENSXCOP00000023518	ENSXCOP00000002985	BCL2 like 1.	Mitogen-activated protein kinase.	0.933
BCL2L1	Mfn1	ENSXCOP00000023518	ENSXCOP00000003773	BCL2 like 1.	Mitofusin 1b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.461
BCL2L1	Mfn2	ENSXCOP00000023518	ENSXCOP00000002651	BCL2 like 1.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.461