(119 nodes) Cellular senescence network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Mtor	Mechanistic target of rapamycin kinase. (922 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	LOC114138091	Voltage-dependent anion channel 2. (283 aa)
	smad3	Mothers against decapentaplegic homolog. (425 aa)
	ENSXCOP00000001107	RHD domain-containing protein. (452 aa)
	ENSXCOP00000001113	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (445 aa)
	ENSXCOP00000001311	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (309 aa)
	Nfatc1	RHD domain-containing protein. (674 aa)
	Ets1	V-ets avian erythroblastosis virus E26 oncogene homolog 1. (397 aa)
	LOC114139436	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	Traf3ip2	SEFIR domain-containing protein. (105 aa)
	Lin37	Lin-37 DREAM MuvB core complex component. (238 aa)
	LOC114134172	Zinc finger protein 36, C3H type-like 1a. (370 aa)
	LOC114161603	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	Tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (332 aa)
	Rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (396 aa)
	ENSXCOP00000002875	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (289 aa)
	ENSXCOP00000002896	Cyclin B2; Belongs to the cyclin family. (386 aa)
	Rad1	RAD1 homolog (S. pombe). (202 aa)
	Nfatc4	RHD domain-containing protein. (237 aa)
	Cacna1d	Ion_trans domain-containing protein. (212 aa)
	LOC114134723	Fork-head domain-containing protein. (604 aa)
	ENSXCOP00000004330	E2F_TDP domain-containing protein. (102 aa)
	ENSXCOP00000004360	Fork-head domain-containing protein. (241 aa)
	ENSXCOP00000004664	Cyclin D3; Belongs to the cyclin family. (261 aa)
	LOC114136223	Cyclin-dependent kinase inhibitor 1A. (156 aa)
	ENSXCOP00000004885	Protein kinase domain-containing protein. (209 aa)
	Vdac1	Voltage-dependent anion channel 1. (261 aa)
	foxo3	Forkhead box O3b. (659 aa)
	Lin9	Lin-9 DREAM MuvB core complex component. (467 aa)
	LOC114151072	Insulin-like growth factor binding protein 3. (285 aa)
	Itpr1	Inositol 1,4,5-trisphosphate receptor, type 1b. (993 aa)
	LOC114158174	Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (223 aa)
	Pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	Slc25a4	Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
	LOC114157395	V-rel avian reticuloendotheliosis viral oncogene homolog A. (628 aa)
	ENSXCOP00000007470	Cyclin D2, a; Belongs to the cyclin family. (296 aa)
	Foxo1	Forkhead box O1 a. (663 aa)
	VDAC2	Voltage dependent anion channel 2. (283 aa)
	Sirt1	Sirtuin 1. (677 aa)
	Serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
	ENSXCOP00000008004	Ig-like domain-containing protein; Belongs to the MHC class I family. (320 aa)
	ENSXCOP00000008237	Uncharacterized protein. (408 aa)
	Gadd45g	Growth arrest and DNA-damage-inducible, gamma a. (154 aa)
	LOC114153516	Fork-head domain-containing protein. (635 aa)
	LOC114152903	Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	Gadd45a	Growth arrest and DNA-damage-inducible, alpha, a. (159 aa)
	LOC114141391	Uncharacterized protein. (461 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	LOC114147892	RAS related. (197 aa)
	ENSXCOP00000010846	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (944 aa)
	ENSXCOP00000010985	V-akt murine thymoma viral oncogene homolog 3b; Belongs to the protein kinase superfamily. (498 aa)
	ENSXCOP00000011039	SEFIR domain-containing protein. (108 aa)
	gata4	GATA binding protein 4. (396 aa)
	ENSXCOP00000011147	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family. (200 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
	ENSXCOP00000011821	Zgc:55262; Belongs to the peptidase C2 family. (677 aa)
	LOC114157299	C-X-C motif chemokine. (104 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	ENSXCOP00000012982	Transforming growth factor beta; Belongs to the TGF-beta family. (389 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	ENSXCOP00000013013	Uncharacterized protein; Belongs to the peptidase C2 family. (837 aa)
	ENSXCOP00000013028	Calpain 1, (mu/I) large subunit a; Belongs to the peptidase C2 family. (712 aa)
	Ccna1	Cyclin A1; Belongs to the cyclin family. (397 aa)
	ENSXCOP00000013576	Calpain 2, (m/II) large subunit b; Belongs to the peptidase C2 family. (377 aa)
	Lin52	Lin-52 DREAM MuvB core complex component. (116 aa)
	Mapk1	Mitogen-activated protein kinase. (357 aa)
	ENSXCOP00000014535	Retinoblastoma binding protein 4. (452 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (442 aa)
	cdkn2b	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)
	ENSXCOP00000015339	Mitogen-activated protein kinase. (353 aa)
	Nfatc3	Nuclear factor of activated T cells 3a. (1069 aa)
	ENSXCOP00000016600	Uncharacterized protein. (453 aa)
	ENSXCOP00000016650	Serine/threonine-protein phosphatase. (476 aa)
	Mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (664 aa)
	ENSXCOP00000017651	V-akt murine thymoma viral oncogene homolog 3a. (162 aa)
	LOC114143947	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
	LOC114160881	Cyclin D2, b; Belongs to the cyclin family. (294 aa)
	PPP3R1	Protein phosphatase 3 regulatory subunit B, alpha. (184 aa)
	Cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (224 aa)
	ENSXCOP00000018784	Ig-like domain-containing protein; Belongs to the MHC class I family. (317 aa)
	ENSXCOP00000018792	MHC_I-like_Ag-recog domain-containing protein. (145 aa)
	ENSXCOP00000018839	Ribosomal_L7Ae domain-containing protein. (186 aa)
	MRAS	Muscle RAS oncogene homolog. (132 aa)
	Nfkb1	RHD domain-containing protein. (80 aa)
	LOC114160673	Cyclin-dependent kinase inhibitor 1D. (178 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (282 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	ENSXCOP00000020549	Homeodomain interacting protein kinase 1a. (1079 aa)
	ENSXCOP00000021013	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (84 aa)
	ENSXCOP00000022353	Myelocytomatosis oncogene homolog. (357 aa)
	Trpv4	Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (819 aa)
	ENSXCOP00000022928	Serine/threonine-protein phosphatase. (490 aa)
	ENSXCOP00000022969	Serine/threonine-protein phosphatase. (491 aa)
	LOC114155135	Uncharacterized protein. (119 aa)
	ENSXCOP00000023377	Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (330 aa)
	ENSXCOP00000023549	Uncharacterized protein. (100 aa)
	ENSXCOP00000023682	Retinoblastoma binding protein 4, like. (382 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	Pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (521 aa)
	Ccne1	Cyclin E1; Belongs to the cyclin family. (284 aa)
	ENSXCOP00000024175	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	ENSXCOP00000024230	Cyclin Dx; Belongs to the cyclin family. (294 aa)
	ENSXCOP00000024246	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (407 aa)
	Trpm7	LSDAT_euk domain-containing protein. (316 aa)
	LOC114160036	Zgc:55558. (187 aa)
	Calml4	Calmodulin-like 4a. (117 aa)
	SMAD3	Mothers against decapentaplegic homolog. (427 aa)
	ENSXCOP00000024620	Mitogen-activated protein kinase 14b. (103 aa)
	Cdk4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (316 aa)
	ENSXCOP00000024964	Ig-like domain-containing protein; Belongs to the MHC class I family. (424 aa)
	ENSXCOP00000025011	Inositol 1,4,5-trisphosphate receptor, type 1a. (2683 aa)
	ENSXCOP00000025153	Nuclear factor of activated T cells 1. (395 aa)
	Rheb	Ras homolog, mTORC1 binding. (189 aa)
	ENSXCOP00000026227	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	ENSXCOP00000001113	ENSXCOP00000014687	ENSXCOP00000001113	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.487
Akt1	ENSXCOP00000004360	ENSXCOP00000014687	ENSXCOP00000004360	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.962
Akt1	ENSXCOP00000008237	ENSXCOP00000014687	ENSXCOP00000008237	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.799
Akt1	ENSXCOP00000010846	ENSXCOP00000014687	ENSXCOP00000010846	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.822
Akt1	ENSXCOP00000011147	ENSXCOP00000014687	ENSXCOP00000011147	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.420
Akt1	ENSXCOP00000016600	ENSXCOP00000014687	ENSXCOP00000016600	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.799
Akt1	ENSXCOP00000024246	ENSXCOP00000014687	ENSXCOP00000024246	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.925
Akt1	Foxo1	ENSXCOP00000014687	ENSXCOP00000007707	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1 a.	0.962
Akt1	LOC114134172	ENSXCOP00000014687	ENSXCOP00000002248	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Zinc finger protein 36, C3H type-like 1a.	0.402
Akt1	LOC114134723	ENSXCOP00000014687	ENSXCOP00000004290	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.962
Akt1	LOC114136223	ENSXCOP00000014687	ENSXCOP00000004782	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1A.	0.949
Akt1	LOC114141391	ENSXCOP00000014687	ENSXCOP00000009701	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.799
Akt1	LOC114153516	ENSXCOP00000014687	ENSXCOP00000008963	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.959
Akt1	LOC114160673	ENSXCOP00000014687	ENSXCOP00000019541	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1D.	0.949
Akt1	Mapk1	ENSXCOP00000014687	ENSXCOP00000014487	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.925
Akt1	Mtor	ENSXCOP00000014687	ENSXCOP00000000077	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mechanistic target of rapamycin kinase.	0.970
Akt1	PIK3CA	ENSXCOP00000014687	ENSXCOP00000009802	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.822
Akt1	Pik3cb	ENSXCOP00000014687	ENSXCOP00000006609	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.822
Akt1	Pik3r1	ENSXCOP00000014687	ENSXCOP00000023771	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	0.799
Akt1	Rheb	ENSXCOP00000014687	ENSXCOP00000025792	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras homolog, mTORC1 binding.	0.475