(41 nodes) RIG-I-like receptor signaling pathway network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXCOP00000000005	B30.2/SPRY domain-containing protein. (264 aa)
	ENSXCOP00000001533	Mitogen-activated protein kinase. (420 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (299 aa)
	ENSXCOP00000002875	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (289 aa)
	Mapk10	Mitogen-activated protein kinase. (384 aa)
	LOC114149726	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	LOC114139131	Mitogen-activated protein kinase. (420 aa)
	Tbkbp1	TBK1 binding protein 1. (637 aa)
	ENSXCOP00000004885	Protein kinase domain-containing protein. (209 aa)
	ENSXCOP00000005178	Uncharacterized protein. (169 aa)
	Mavs	CARD_2 domain-containing protein. (542 aa)
	Pin1	WW domain-containing protein. (132 aa)
	LOC114157395	V-rel avian reticuloendotheliosis viral oncogene homolog A. (628 aa)
	ENSXCOP00000008879	Si:ch211-1n9.6. (50 aa)
	tkfc	Triokinase/FMN cyclase. (578 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (584 aa)
	ENSXCOP00000010789	DED domain-containing protein. (136 aa)
	LOC114158792	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (301 aa)
	LOC114154033	Uncharacterized protein. (117 aa)
	LOC114157299	C-X-C motif chemokine. (104 aa)
	ENSXCOP00000012115	Protein kinase domain-containing protein. (159 aa)
	IL12B-2	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (335 aa)
	Tradd	Tnfrsf1a-associated via death domain. (247 aa)
	ENSXCOP00000015312	RING-type domain-containing protein. (103 aa)
	ENSXCOP00000015339	Mitogen-activated protein kinase. (353 aa)
	Tbk1	Protein kinase domain-containing protein. (134 aa)
	ENSXCOP00000015859	Component of inhibitor of nuclear factor kappa B kinase complex. (701 aa)
	ENSXCOP00000015874	Mitogen-activated protein kinase. (384 aa)
	sting1	Transmembrane protein 173. (398 aa)
	Cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (919 aa)
	LOC114143947	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	Nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (323 aa)
	Nfkb1	RHD domain-containing protein. (80 aa)
	fadd	Uncharacterized protein. (196 aa)
	Ddx3x	DEAD-box helicase 3 X-linked a; Belongs to the DEAD box helicase family. (693 aa)
	ENSXCOP00000024620	Mitogen-activated protein kinase 14b. (103 aa)
	Ifih1	Interferon induced with helicase C domain 1. (974 aa)
	Tank	TBD domain-containing protein. (233 aa)
	atg12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (117 aa)
	Irf7	Interferon regulatory factor 7. (502 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cyld	ENSXCOP00000010789	ENSXCOP00000017244	ENSXCOP00000010789	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	DED domain-containing protein.	0.917
Cyld	ENSXCOP00000012115	ENSXCOP00000017244	ENSXCOP00000012115	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Protein kinase domain-containing protein.	0.452
Cyld	ENSXCOP00000015859	ENSXCOP00000017244	ENSXCOP00000015859	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.578
Cyld	Ifih1	ENSXCOP00000017244	ENSXCOP00000025894	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Interferon induced with helicase C domain 1.	0.593
Cyld	LOC114149726	ENSXCOP00000017244	ENSXCOP00000003601	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.509
Cyld	Tbk1	ENSXCOP00000017244	ENSXCOP00000015834	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Protein kinase domain-containing protein.	0.573
Cyld	Tradd	ENSXCOP00000017244	ENSXCOP00000015167	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Tnfrsf1a-associated via death domain.	0.687
Cyld	fadd	ENSXCOP00000017244	ENSXCOP00000023094	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.606
Cyld	map3k7	ENSXCOP00000017244	ENSXCOP00000009743	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Mitogen-activated protein kinase kinase kinase 7.	0.452
Cyld	traf6	ENSXCOP00000017244	ENSXCOP00000018560	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.817
Ddx3x	Tbk1	ENSXCOP00000024089	ENSXCOP00000015834	DEAD-box helicase 3 X-linked a; Belongs to the DEAD box helicase family.	Protein kinase domain-containing protein.	0.932
ENSXCOP00000000005	ENSXCOP00000008879	ENSXCOP00000000005	ENSXCOP00000008879	B30.2/SPRY domain-containing protein.	Si:ch211-1n9.6.	0.900
ENSXCOP00000000005	ENSXCOP00000015312	ENSXCOP00000000005	ENSXCOP00000015312	B30.2/SPRY domain-containing protein.	RING-type domain-containing protein.	0.900
ENSXCOP00000001533	ENSXCOP00000012115	ENSXCOP00000001533	ENSXCOP00000012115	Mitogen-activated protein kinase.	Protein kinase domain-containing protein.	0.929
ENSXCOP00000001533	LOC114139131	ENSXCOP00000001533	ENSXCOP00000004298	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.911
ENSXCOP00000001533	map3k7	ENSXCOP00000001533	ENSXCOP00000009743	Mitogen-activated protein kinase.	Mitogen-activated protein kinase kinase kinase 7.	0.929
ENSXCOP00000002875	ENSXCOP00000012115	ENSXCOP00000002875	ENSXCOP00000012115	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Protein kinase domain-containing protein.	0.929
ENSXCOP00000002875	map3k7	ENSXCOP00000002875	ENSXCOP00000009743	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase kinase kinase 7.	0.929
ENSXCOP00000004885	ENSXCOP00000012115	ENSXCOP00000004885	ENSXCOP00000012115	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.929
ENSXCOP00000004885	map3k7	ENSXCOP00000004885	ENSXCOP00000009743	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.929