(70 nodes) Progesterone-mediated oocyte maturation network (Xiphophorus couchianus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	Cpeb1	Cytoplasmic polyadenylation element binding protein 1b. (284 aa)
	Bub1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (202 aa)
	ENSXCOP00000001533	Mitogen-activated protein kinase. (420 aa)
	Kif22	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (627 aa)
	LOC114161603	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	ENSXCOP00000002727	IlGF domain-containing protein. (187 aa)
	LOC114158441	Heat shock protein 90, alpha (cytosolic), class B member 1. (723 aa)
	Adcy3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
	ENSXCOP00000002875	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (289 aa)
	ENSXCOP00000002896	Cyclin B2; Belongs to the cyclin family. (386 aa)
	Mapk10	Mitogen-activated protein kinase. (384 aa)
	Mad2l2	Mitotic arrest deficient 2 like 2. (200 aa)
	Prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (333 aa)
	LOC114139131	Mitogen-activated protein kinase. (420 aa)
	ENSXCOP00000004781	Adenylate cyclase 1a; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (348 aa)
	ENSXCOP00000004885	Protein kinase domain-containing protein. (209 aa)
	Rps6ka1	Non-specific serine/threonine protein kinase. (681 aa)
	Pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	PLK1	Serine/threonine-protein kinase PLK. (570 aa)
	anapc13	Anaphase promoting complex subunit 13. (74 aa)
	LOC114144764	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
	ENSXCOP00000008237	Uncharacterized protein. (408 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (744 aa)
	mos	V-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily. (337 aa)
	LOC114141391	Uncharacterized protein. (461 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	Anapc10	Anaphase promoting complex subunit 10. (118 aa)
	ENSXCOP00000009982	Fizzy/cell division cycle 20 related 1b. (483 aa)
	ENSXCOP00000010846	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (944 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (493 aa)
	ENSXCOP00000010985	V-akt murine thymoma viral oncogene homolog 3b; Belongs to the protein kinase superfamily. (498 aa)
	pgr	Progesterone receptor. (638 aa)
	Cpeb2	RRM domain-containing protein. (376 aa)
	anapc7	Anaphase promoting complex subunit 7. (565 aa)
	cdc26	Cell division cycle 26 homolog. (94 aa)
	LOC114134997	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (355 aa)
	Ccna1	Cyclin A1; Belongs to the cyclin family. (397 aa)
	ENSXCOP00000013661	Cytoplasmic polyadenylation element binding protein 4a. (715 aa)
	Adcy5	AC_N domain-containing protein. (440 aa)
	ENSXCOP00000014275	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (303 aa)
	Mapk1	Mitogen-activated protein kinase. (357 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (442 aa)
	Spdya	Speedy/RINGO cell cycle regulator family member A. (305 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	ENSXCOP00000015339	Mitogen-activated protein kinase. (353 aa)
	Rps6ka6	Non-specific serine/threonine protein kinase. (694 aa)
	ENSXCOP00000015874	Mitogen-activated protein kinase. (384 aa)
	ENSXCOP00000016600	Uncharacterized protein. (453 aa)
	Adcy7	Adenylate cyclase 7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (476 aa)
	Mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast). (198 aa)
	ENSXCOP00000017651	V-akt murine thymoma viral oncogene homolog 3a. (162 aa)
	Cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (224 aa)
	ENSXCOP00000019718	Uncharacterized protein. (315 aa)
	ENSXCOP00000019943	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
	LOC114146401	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	ENSXCOP00000020037	A-Raf proto-oncogene, serine/threonine kinase. (586 aa)
	Anapc5	Anaphase promoting complex subunit 5. (740 aa)
	Rps6ka3	Ribosomal protein S6 kinase, polypeptide 3b. (312 aa)
	Pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (521 aa)
	ENSXCOP00000024246	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (407 aa)
	Cdc27	Cell division cycle 27. (329 aa)
	LOC114160036	Zgc:55558. (187 aa)
	ENSXCOP00000024620	Mitogen-activated protein kinase 14b. (103 aa)
	Cdc16	Cell division cycle 16 homolog (S. cerevisiae). (498 aa)
	LOC114135550	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (355 aa)
	ENSXCOP00000027158	Tyrosine-protein kinase receptor. (1403 aa)
	LOC114159947	Uncharacterized protein. (354 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adcy3	CPEB4	ENSXCOP00000002841	ENSXCOP00000008426	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cytoplasmic polyadenylation element binding protein 4.	0.598
Adcy3	Cpeb2	ENSXCOP00000002841	ENSXCOP00000011352	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	RRM domain-containing protein.	0.598
Adcy3	ENSXCOP00000004781	ENSXCOP00000002841	ENSXCOP00000004781	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 1a; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.406
Adcy3	ENSXCOP00000014275	ENSXCOP00000002841	ENSXCOP00000014275	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.437
Adcy3	ENSXCOP00000019718	ENSXCOP00000002841	ENSXCOP00000019718	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.767
Adcy3	LOC114134997	ENSXCOP00000002841	ENSXCOP00000013064	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.767
Adcy3	LOC114135550	ENSXCOP00000002841	ENSXCOP00000026787	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	0.767
Adcy3	LOC114144764	ENSXCOP00000002841	ENSXCOP00000008039	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.767
Adcy3	LOC114146401	ENSXCOP00000002841	ENSXCOP00000019991	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.921
Adcy3	LOC114159947	ENSXCOP00000002841	ENSXCOP00000027388	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.767
Adcy3	Prkacb	ENSXCOP00000002841	ENSXCOP00000003931	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.921
Adcy5	Adcy7	ENSXCOP00000013835	ENSXCOP00000016848	AC_N domain-containing protein.	Adenylate cyclase 7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.513
Adcy5	ENSXCOP00000019718	ENSXCOP00000013835	ENSXCOP00000019718	AC_N domain-containing protein.	Uncharacterized protein.	0.755
Adcy5	LOC114134997	ENSXCOP00000013835	ENSXCOP00000013064	AC_N domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.755
Adcy5	LOC114135550	ENSXCOP00000013835	ENSXCOP00000026787	AC_N domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	0.755
Adcy5	LOC114144764	ENSXCOP00000013835	ENSXCOP00000008039	AC_N domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.755
Adcy5	LOC114146401	ENSXCOP00000013835	ENSXCOP00000019991	AC_N domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.919
Adcy5	LOC114159947	ENSXCOP00000013835	ENSXCOP00000027388	AC_N domain-containing protein.	Uncharacterized protein.	0.755
Adcy5	Prkacb	ENSXCOP00000013835	ENSXCOP00000003931	AC_N domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.919
Adcy7	Adcy5	ENSXCOP00000016848	ENSXCOP00000013835	Adenylate cyclase 7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.513