(83 nodes) Melanogenesis network (Xiphophorus couchianus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	LOC114154374	Uncharacterized protein. (359 aa)
	Wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (427 aa)
	ENSXCOP00000001809	Endothelin 1. (173 aa)
	Adcy3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
	tyrp1	Tyrosinase related protein 1. (525 aa)
	Prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (333 aa)
	GNAS	GNAS complex locus. (379 aa)
	ENSXCOP00000004781	Adenylate cyclase 1a; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (348 aa)
	Fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	LOC114152040	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	ENSXCOP00000006465	Uncharacterized protein. (75 aa)
	ENSXCOP00000007266	Protein kinase C, beta a. (287 aa)
	LOC114144764	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	LOC114152015	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	ENSXCOP00000011147	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family. (200 aa)
	Kit	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (835 aa)
	Wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	LOC114134997	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (355 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (309 aa)
	ENSXCOP00000013313	Kit ligand a. (263 aa)
	Lef1	Lymphoid enhancer-binding factor 1. (331 aa)
	ENSXCOP00000013460	Guanine nucleotide binding protein (G protein), alpha 11a (Gq class). (328 aa)
	ENSXCOP00000013488	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (386 aa)
	ENSXCOP00000013732	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
	LOC114140646	Proopiomelanocortin. (184 aa)
	ENSXCOP00000013734	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
	ENSXCOP00000013776	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (342 aa)
	Adcy5	AC_N domain-containing protein. (440 aa)
	ENSXCOP00000014275	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (303 aa)
	Mapk1	Mitogen-activated protein kinase. (357 aa)
	ENSXCOP00000014725	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
	ENSXCOP00000015197	Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b. (285 aa)
	Mc1r	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (319 aa)
	ENSXCOP00000015403	Agouti domain-containing protein. (125 aa)
	ENSXCOP00000015511	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (280 aa)
	TYR	Tyrosinase. (545 aa)
	ENSXCOP00000016824	Uncharacterized protein. (448 aa)
	Adcy7	Adenylate cyclase 7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (476 aa)
	ENSXCOP00000016992	Uncharacterized protein. (117 aa)
	Tyr	Tyrosinase. (537 aa)
	Fzd9	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
	EDNRB	Endothelin receptor type B. (338 aa)
	ENSXCOP00000017838	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
	ENSXCOP00000018121	KIT proto-oncogene, receptor tyrosine kinase b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (920 aa)
	ENSXCOP00000018139	Tyrosinase_Cu-bd domain-containing protein. (244 aa)
	ENSXCOP00000018453	GNAS complex locus. (378 aa)
	Dvl1	DIX domain-containing protein. (82 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
	Wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (148 aa)
	ENSXCOP00000019552	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (114 aa)
	Creb3l2	cAMP responsive element binding protein 3-like 2. (532 aa)
	ENSXCOP00000019718	Uncharacterized protein. (315 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (663 aa)
	ENSXCOP00000019943	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
	LOC114146401	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	Wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa)
	Fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	ENSXCOP00000021088	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
	ctnnb1	Catenin (cadherin-associated protein), beta 1. (783 aa)
	ENSXCOP00000022335	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Fzd6	FZ domain-containing protein. (126 aa)
	ENSXCOP00000022978	FZ domain-containing protein. (220 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
	ENSXCOP00000024246	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (407 aa)
	LOC114160036	Zgc:55558. (187 aa)
	Calml4	Calmodulin-like 4a. (117 aa)
	ENSXCOP00000024535	CaMKII_AD domain-containing protein. (146 aa)
	ENSXCOP00000024825	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (576 aa)
	Gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (423 aa)
	ENSXCOP00000025512	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	Dct	Dopachrome tautomerase. (513 aa)
	LOC114155974	Uncharacterized protein. (209 aa)
	LOC114139694	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
	LOC114135550	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (355 aa)
	ENSXCOP00000027005	Uncharacterized protein. (740 aa)
	ENSXCOP00000027368	cAMP responsive element binding protein 1. (324 aa)
	LOC114159947	Uncharacterized protein. (354 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	Hras	HRas proto-oncogene, GTPase a. (201 aa)
	ENSXCOP00000028003	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)

Your Current Organism:

Xiphophorus couchianus

NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adcy3	Calml4	ENSXCOP00000002841	ENSXCOP00000024394	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like 4a.	0.912
Adcy3	ENSXCOP00000004781	ENSXCOP00000002841	ENSXCOP00000004781	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 1a; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.406
Adcy3	ENSXCOP00000011147	ENSXCOP00000002841	ENSXCOP00000011147	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.920
Adcy3	ENSXCOP00000014275	ENSXCOP00000002841	ENSXCOP00000014275	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.437
Adcy3	ENSXCOP00000018453	ENSXCOP00000002841	ENSXCOP00000018453	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.960
Adcy3	ENSXCOP00000019718	ENSXCOP00000002841	ENSXCOP00000019718	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.767
Adcy3	GNAS	ENSXCOP00000002841	ENSXCOP00000004157	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.960
Adcy3	LOC114134997	ENSXCOP00000002841	ENSXCOP00000013064	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.767
Adcy3	LOC114135550	ENSXCOP00000002841	ENSXCOP00000026787	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	0.767
Adcy3	LOC114144764	ENSXCOP00000002841	ENSXCOP00000008039	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.767
Adcy3	LOC114146401	ENSXCOP00000002841	ENSXCOP00000019991	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.921
Adcy3	LOC114159947	ENSXCOP00000002841	ENSXCOP00000027388	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.767
Adcy3	Prkacb	ENSXCOP00000002841	ENSXCOP00000003931	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.921
Adcy5	Adcy7	ENSXCOP00000013835	ENSXCOP00000016848	AC_N domain-containing protein.	Adenylate cyclase 7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.513
Adcy5	ENSXCOP00000018453	ENSXCOP00000013835	ENSXCOP00000018453	AC_N domain-containing protein.	GNAS complex locus.	0.959
Adcy5	ENSXCOP00000019718	ENSXCOP00000013835	ENSXCOP00000019718	AC_N domain-containing protein.	Uncharacterized protein.	0.755
Adcy5	GNAS	ENSXCOP00000013835	ENSXCOP00000004157	AC_N domain-containing protein.	GNAS complex locus.	0.959
Adcy5	LOC114134997	ENSXCOP00000013835	ENSXCOP00000013064	AC_N domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.755
Adcy5	LOC114135550	ENSXCOP00000013835	ENSXCOP00000026787	AC_N domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	0.755
Adcy5	LOC114144764	ENSXCOP00000013835	ENSXCOP00000008039	AC_N domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.755