STRINGSTRING
ftsA ftsA divIB divIB murG murG murD murD mraY mraY LGAS_1743 LGAS_1743 murE murE murC murC LGAS_1344 LGAS_1344 whiA whiA murB murB murA murA LGAS_1232 LGAS_1232 LGAS_1225 LGAS_1225 ftsL ftsL LGAS_1207 LGAS_1207 murF murF LGAS_0273 LGAS_0273 xerD xerD scpA scpA scpB scpB LGAS_0900 LGAS_0900 xerC xerC LGAS_1022 LGAS_1022 engB engB tig tig LGAS_1180 LGAS_1180 LGAS_1197 LGAS_1197 LGAS_1199 LGAS_1199 sepF sepF ftsZ ftsZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (456 aa)
divIBCell division protein FtsQ; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily. (287 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (370 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa)
mraYPhospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (319 aa)
LGAS_1743Effector of nucleoid occlusion Noc; Belongs to the ParB family. (293 aa)
murEUDP-N-acetylmuramyl tripeptide synthase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (523 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (437 aa)
LGAS_1344DNA translocase FtsK; Belongs to the FtsK/SpoIIIE/SftA family. (808 aa)
whiAHypothetical protein; Involved in cell division and chromosome segregation. (313 aa)
murBUDP-N-acetylmuramate dehydrogenase; Cell wall formation. (303 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa)
LGAS_1232Cell division membrane protein; Belongs to the SEDS family. (398 aa)
LGAS_1225Negative regulator of septation ring formation. (580 aa)
ftsLCell division protein FtsL; Essential cell division protein; Belongs to the FtsL family. (120 aa)
LGAS_1207Cell division protein FtsI/penicillin-binding protein 2. (716 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (455 aa)
LGAS_0273Septum formation initiator. (125 aa)
xerDTyrosine recombinase XerD subunit; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (302 aa)
scpACondensin subunit ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (247 aa)
scpBCondensin subunit ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (199 aa)
LGAS_0900Integrase; Belongs to the 'phage' integrase family. (322 aa)
xerCTyrosine recombinase XerC subunit; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (307 aa)
LGAS_1022Cell division initiation protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (145 aa)
engBPredicted GTPase; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (194 aa)
tigFKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (449 aa)
LGAS_1180Cell division-specific peptidoglycan biosynthesis regulator FtsW; Belongs to the SEDS family. (394 aa)
LGAS_1197Cell division initiation protein. (263 aa)
LGAS_1199Cell division membrane protein. (98 aa)
sepFCell division protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (144 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (456 aa)
Your Current Organism:
Lactobacillus gasseri
NCBI taxonomy Id: 324831
Other names: L. gasseri ATCC 33323 = JCM 1131, Lactobacillus gasseri ATCC 33323, Lactobacillus gasseri ATCC 33323 = JCM 1131, Lactobacillus gasseri DSM 20243, Lactobacillus gasseri NCDO 2233
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.