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phnC phnC LGAS_0775 LGAS_0775 gmk gmk pstB pstB ruvB ruvB purA purA radA radA LGAS_0333 LGAS_0333 adk adk fusA fusA LGAS_0283 LGAS_0283 pyrG pyrG ugpC ugpC LGAS_1863 LGAS_1863 LGAS_1742 LGAS_1742 ychF ychF LGAS_1721 LGAS_1721 LGAS_1694 LGAS_1694 LGAS_1642 LGAS_1642 LGAS_1443 LGAS_1443 prfC prfC LGAS_1350 LGAS_1350 LGAS_1344 LGAS_1344 recA recA secA secA rapZ rapZ tdk tdk atpA atpA atpD atpD typA typA eftuLG21 eftuLG21 LGAS_1120 LGAS_1120 hslU hslU ylqF ylqF obgE obgE LGAS_0818 LGAS_0818 ffh ffh
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
phnCABC-type phosphate/phosphonate transport system, ATPase component; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (261 aa)
LGAS_0775ABC-type oligopeptide transport system, ATPase component; Belongs to the ABC transporter superfamily. (322 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa)
pstBPhosphate ABC transporter ATP-binding protein, PhoT family; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (266 aa)
ruvBHolliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (339 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
radADNA replication and repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (459 aa)
LGAS_0333Predicted kinase. (311 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
fusATranslation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (698 aa)
LGAS_0283ATP-binding subunit of Clp protease and DnaK/DnaJ chaperones; Belongs to the ClpA/ClpB family. (838 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (554 aa)
ugpCCarbohydrate ABC transporter ATP-binding protein, CUT1 family; TC 3.A.1.1.-; Belongs to the ABC transporter superfamily. (367 aa)
LGAS_1863Deoxynucleoside kinase. (225 aa)
LGAS_1742Chromosome segregation ATPase. (257 aa)
ychFPredicted GTPase, probable translation factor; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (366 aa)
LGAS_1721ABC-type Mn/Zn transport system, ATPase component. (219 aa)
LGAS_1694ABC-type antimicrobial peptide transport system, ATPase component. (248 aa)
LGAS_1642Carbohydrate ABC transporter ATP-binding protein, CUT1 family; TC 3.A.1.1.-; Belongs to the ABC transporter superfamily. (361 aa)
LGAS_1443ABC-type multidrug transport system, ATPase component. (248 aa)
prfCBacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (522 aa)
LGAS_1350Hypothetical protein. (403 aa)
LGAS_1344DNA translocase FtsK; Belongs to the FtsK/SpoIIIE/SftA family. (808 aa)
recARecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (364 aa)
secAProtein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (799 aa)
rapZPredicted P-loop-containing kinase; Displays ATPase and GTPase activities. (291 aa)
tdkThymidine kinase. (199 aa)
atpAATP synthase F1 subcomplex alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (506 aa)
atpDATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (480 aa)
typAStress response membrane GTPase. (618 aa)
eftuLG21Translation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (405 aa)
LGAS_1120Phosphate starvation-inducible protein PhoH, predicted ATPase. (319 aa)
hslUATP-dependent protease HslVU (ClpYQ), ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (464 aa)
ylqFRas superfamily GTP-binding protein YlqF; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (279 aa)
obgEPredicted GTPase; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (428 aa)
LGAS_0818ATPase component of ABC transporter with duplicated ATPase domain. (501 aa)
ffhSignal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (476 aa)
Your Current Organism:
Lactobacillus gasseri
NCBI taxonomy Id: 324831
Other names: L. gasseri ATCC 33323 = JCM 1131, Lactobacillus gasseri ATCC 33323, Lactobacillus gasseri ATCC 33323 = JCM 1131, Lactobacillus gasseri DSM 20243, Lactobacillus gasseri NCDO 2233
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