(13 nodes) JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, and Free ubiquitin chain polymerization network (Neolamprologus brichardi)

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Your Input:
	LOC102777348	Ubiquitin-like domain-containing protein. (126 aa)
	ENSNBRP00000004179	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (163 aa)
	LOC102791696	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	LOC102780233	Ubiquitin-conjugating enzyme E2 variant 1. (151 aa)
	LOC102786804	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	LOC102798988	Ribosomal protein S27a. (156 aa)
	LOC102795343	Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
	LOC102785573	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	ENSNBRP00000024395	UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa)
	LOC102798684	Zinc finger, AN1-type domain 4. (687 aa)
	LOC102788123	Baculoviral IAP repeat containing 6. (4745 aa)
	LOC102783470	Ubiquitin-like domain-containing protein. (128 aa)
	LOC102787073	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)

Your Current Organism:

Neolamprologus brichardi

NCBI taxonomy Id: 32507
Other names: Lamprologus brichardi, N. brichardi, lyretail cichlid

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSNBRP00000004179	ENSNBRP00000024395	ENSNBRP00000004179	ENSNBRP00000024395	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.988
ENSNBRP00000004179	LOC102777348	ENSNBRP00000004179	ENSNBRP00000002034	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.955
ENSNBRP00000004179	LOC102780233	ENSNBRP00000004179	ENSNBRP00000009279	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 variant 1.	0.990
ENSNBRP00000004179	LOC102783470	ENSNBRP00000004179	ENSNBRP00000028817	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.955
ENSNBRP00000004179	LOC102785573	ENSNBRP00000004179	ENSNBRP00000020821	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.857
ENSNBRP00000004179	LOC102786804	ENSNBRP00000004179	ENSNBRP00000011887	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.857
ENSNBRP00000004179	LOC102787073	ENSNBRP00000004179	ENSNBRP00000028967	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.983
ENSNBRP00000004179	LOC102788123	ENSNBRP00000004179	ENSNBRP00000027828	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Baculoviral IAP repeat containing 6.	0.908
ENSNBRP00000004179	LOC102791696	ENSNBRP00000004179	ENSNBRP00000004798	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family.	0.841
ENSNBRP00000004179	LOC102795343	ENSNBRP00000004179	ENSNBRP00000015224	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 variant 2.	0.995
ENSNBRP00000004179	LOC102798684	ENSNBRP00000004179	ENSNBRP00000027403	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Zinc finger, AN1-type domain 4.	0.827
ENSNBRP00000004179	LOC102798988	ENSNBRP00000004179	ENSNBRP00000013855	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ribosomal protein S27a.	0.985
ENSNBRP00000024395	ENSNBRP00000004179	ENSNBRP00000024395	ENSNBRP00000004179	UBIQUITIN_CONJUGAT_2 domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.988
ENSNBRP00000024395	LOC102777348	ENSNBRP00000024395	ENSNBRP00000002034	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.999
ENSNBRP00000024395	LOC102780233	ENSNBRP00000024395	ENSNBRP00000009279	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-conjugating enzyme E2 variant 1.	0.986
ENSNBRP00000024395	LOC102783470	ENSNBRP00000024395	ENSNBRP00000028817	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.999
ENSNBRP00000024395	LOC102785573	ENSNBRP00000024395	ENSNBRP00000020821	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.998
ENSNBRP00000024395	LOC102786804	ENSNBRP00000024395	ENSNBRP00000011887	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.998
ENSNBRP00000024395	LOC102787073	ENSNBRP00000024395	ENSNBRP00000028967	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.960
ENSNBRP00000024395	LOC102788123	ENSNBRP00000024395	ENSNBRP00000027828	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Baculoviral IAP repeat containing 6.	0.999