(7 nodes) MCM OB domain network (Neolamprologus brichardi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC102777806	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (723 aa)
	LOC102787461	Minichromosome maintenance complex component 3; Belongs to the MCM family. (644 aa)
	LOC102784751	DNA helicase; Belongs to the MCM family. (825 aa)
	LOC102776830	DNA helicase; Belongs to the MCM family. (914 aa)
	LOC102783740	DNA helicase; Belongs to the MCM family. (694 aa)
	LOC102795632	DNA helicase; Belongs to the MCM family. (809 aa)
	LOC102797411	Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (609 aa)

Your Current Organism:

Neolamprologus brichardi

NCBI taxonomy Id: 32507
Other names: Lamprologus brichardi, N. brichardi, lyretail cichlid

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102776830	LOC102777806	ENSNBRP00000017795	ENSNBRP00000032110	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
LOC102776830	LOC102783740	ENSNBRP00000017795	ENSNBRP00000015606	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
LOC102776830	LOC102784751	ENSNBRP00000017795	ENSNBRP00000020525	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
LOC102776830	LOC102787461	ENSNBRP00000017795	ENSNBRP00000022735	DNA helicase; Belongs to the MCM family.	Minichromosome maintenance complex component 3; Belongs to the MCM family.	0.999
LOC102776830	LOC102795632	ENSNBRP00000017795	ENSNBRP00000015275	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
LOC102776830	LOC102797411	ENSNBRP00000017795	ENSNBRP00000011878	DNA helicase; Belongs to the MCM family.	Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family.	0.993
LOC102777806	LOC102776830	ENSNBRP00000032110	ENSNBRP00000017795	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
LOC102777806	LOC102783740	ENSNBRP00000032110	ENSNBRP00000015606	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
LOC102777806	LOC102784751	ENSNBRP00000032110	ENSNBRP00000020525	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
LOC102777806	LOC102787461	ENSNBRP00000032110	ENSNBRP00000022735	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Minichromosome maintenance complex component 3; Belongs to the MCM family.	0.999
LOC102777806	LOC102795632	ENSNBRP00000032110	ENSNBRP00000015275	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
LOC102777806	LOC102797411	ENSNBRP00000032110	ENSNBRP00000011878	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family.	0.998
LOC102783740	LOC102776830	ENSNBRP00000015606	ENSNBRP00000017795	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
LOC102783740	LOC102777806	ENSNBRP00000015606	ENSNBRP00000032110	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
LOC102783740	LOC102784751	ENSNBRP00000015606	ENSNBRP00000020525	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
LOC102783740	LOC102787461	ENSNBRP00000015606	ENSNBRP00000022735	DNA helicase; Belongs to the MCM family.	Minichromosome maintenance complex component 3; Belongs to the MCM family.	0.999
LOC102783740	LOC102795632	ENSNBRP00000015606	ENSNBRP00000015275	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
LOC102783740	LOC102797411	ENSNBRP00000015606	ENSNBRP00000011878	DNA helicase; Belongs to the MCM family.	Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family.	0.998
LOC102784751	LOC102776830	ENSNBRP00000020525	ENSNBRP00000017795	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
LOC102784751	LOC102777806	ENSNBRP00000020525	ENSNBRP00000032110	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999