(8 nodes) Sir2 family network (Neolamprologus brichardi)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	LOC102787645	Si:dkey-103i16.6. (441 aa)
	LOC102784512	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (325 aa)
	LOC102794067	Deacetylase sirtuin-type domain-containing protein. (695 aa)
	LOC102784398	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (260 aa)
	LOC102797521	Sirtuin 6. (351 aa)
	LOC102781225	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (330 aa)
	LOC102796672	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (301 aa)
	LOC102796760	Sirtuin 7. (405 aa)

Your Current Organism:

Neolamprologus brichardi

NCBI taxonomy Id: 32507
Other names: Lamprologus brichardi, N. brichardi, lyretail cichlid

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102781225	LOC102784398	ENSNBRP00000029150	ENSNBRP00000019817	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.936
LOC102781225	LOC102784512	ENSNBRP00000029150	ENSNBRP00000017260	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.917
LOC102781225	LOC102787645	ENSNBRP00000029150	ENSNBRP00000004123	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	Si:dkey-103i16.6.	0.936
LOC102781225	LOC102794067	ENSNBRP00000029150	ENSNBRP00000021743	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	Deacetylase sirtuin-type domain-containing protein.	0.915
LOC102781225	LOC102796672	ENSNBRP00000029150	ENSNBRP00000030234	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.915
LOC102781225	LOC102796760	ENSNBRP00000029150	ENSNBRP00000031149	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	Sirtuin 7.	0.922
LOC102781225	LOC102797521	ENSNBRP00000029150	ENSNBRP00000026535	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	Sirtuin 6.	0.939
LOC102784398	LOC102781225	ENSNBRP00000019817	ENSNBRP00000029150	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.936
LOC102784398	LOC102784512	ENSNBRP00000019817	ENSNBRP00000017260	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.886
LOC102784398	LOC102794067	ENSNBRP00000019817	ENSNBRP00000021743	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Deacetylase sirtuin-type domain-containing protein.	0.918
LOC102784398	LOC102796672	ENSNBRP00000019817	ENSNBRP00000030234	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.887
LOC102784398	LOC102796760	ENSNBRP00000019817	ENSNBRP00000031149	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 7.	0.887
LOC102784398	LOC102797521	ENSNBRP00000019817	ENSNBRP00000026535	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 6.	0.898
LOC102784512	LOC102781225	ENSNBRP00000017260	ENSNBRP00000029150	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.917
LOC102784512	LOC102784398	ENSNBRP00000017260	ENSNBRP00000019817	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.886
LOC102784512	LOC102787645	ENSNBRP00000017260	ENSNBRP00000004123	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Si:dkey-103i16.6.	0.889
LOC102784512	LOC102794067	ENSNBRP00000017260	ENSNBRP00000021743	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Deacetylase sirtuin-type domain-containing protein.	0.875
LOC102784512	LOC102796760	ENSNBRP00000017260	ENSNBRP00000031149	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 7.	0.938
LOC102784512	LOC102797521	ENSNBRP00000017260	ENSNBRP00000026535	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 6.	0.937
LOC102787645	LOC102781225	ENSNBRP00000004123	ENSNBRP00000029150	Si:dkey-103i16.6.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.936