(72 nodes) Hedgehog signaling pathway network (Neolamprologus brichardi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSNBRP00000012128	Cullin 1b; Belongs to the cullin family. (343 aa)
	LOC102796281	Si:dkey-88l16.3. (1399 aa)
	LOC102786216	Cyclin D2, b; Belongs to the cyclin family. (294 aa)
	LOC102782029	CULLIN_2 domain-containing protein; Belongs to the cullin family. (637 aa)
	LOC102789342	Cyclin D1; Belongs to the cyclin family. (318 aa)
	LOC102788644	E3 ubiquitin-protein ligase. (755 aa)
	MOSMO	Modulator of smoothened. (167 aa)
	LOC102790562	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (354 aa)
	LOC102778522	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
	SMURF2	SMAD specific E3 ubiquitin protein ligase 2. (693 aa)
	LOC102778151	Cell adhesion associated, oncogene regulated. (1033 aa)
	LOC102792310	Speckle type BTB/POZ protein. (372 aa)
	LOC102779962	Tetraspanin. (305 aa)
	ENSNBRP00000013208	Growth arrest-specific 1b. (261 aa)
	SPOP	Speckle type BTB/POZ protein. (374 aa)
	LOC102794599	Casein kinase 1, gamma 2b; Belongs to the protein kinase superfamily. (465 aa)
	LOC102792918	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (294 aa)
	LOC102779162	G kinase anchoring protein 1. (384 aa)
	LOC102779523	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	LOC102779559	GLI family zinc finger 3. (1592 aa)
	LOC102780952	Low density lipoprotein receptor-related protein 2b. (4228 aa)
	LOC102793888	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (668 aa)
	LOC102799495	BH4_2 domain-containing protein. (198 aa)
	LOC102783010	Low density lipoprotein receptor-related protein 2a. (4460 aa)
	LOC102794703	Patched 1. (1457 aa)
	ENSNBRP00000018573	BCL2 apoptosis regulator b. (224 aa)
	LOC102782412	Multiple EGF-like-domains 8. (2848 aa)
	LOC102794438	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (422 aa)
	LOC102788503	Patched 2. (1206 aa)
	ENSNBRP00000021252	Uncharacterized protein. (83 aa)
	LOC102784778	Arrestin, beta 2a. (406 aa)
	LOC102779560	Limb development membrane protein 1; Belongs to the LIMR family. (492 aa)
	LOC102797312	EvC ciliary complex subunit 1. (957 aa)
	LOC102780316	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (415 aa)
	ENSNBRP00000021766	HH_signal domain-containing protein. (138 aa)
	EVC2	EvC ciliary complex subunit 2. (1348 aa)
	LOC102783756	Limb development membrane protein 1-like. (404 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (766 aa)
	LOC102788047	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (433 aa)
	LOC102789857	Suppressor of fused homolog. (471 aa)
	LOC102786071	Cyclin D2, a; Belongs to the cyclin family. (297 aa)
	LOC102792084	Attractin-like 1b. (1380 aa)
	LOC102793170	Low density lipoprotein receptor-related protein 4. (1842 aa)
	LOC102790666	Uncharacterized protein; Belongs to the protein kinase superfamily. (365 aa)
	LOC102783800	Casein kinase 1, gamma 1; Belongs to the protein kinase superfamily. (423 aa)
	LOC102780049	Speckle type BTB/POZ protein like b. (392 aa)
	LOC102796761	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
	LOC102781676	Uncharacterized protein. (1519 aa)
	LOC102797194	Arrestin, beta 1. (416 aa)
	LOC102796796	Uncharacterized protein. (1368 aa)
	LOC102790013	Uncharacterized protein. (167 aa)
	LOC102783907	Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (415 aa)
	LOC102775717	Growth arrest-specific 1a. (253 aa)
	CSNK1D	Casein kinase 1 delta; Belongs to the protein kinase superfamily. (407 aa)
	LOC102781380	BOC cell adhesion associated, oncogene regulated. (976 aa)
	LOC102777237	Attractin. (1373 aa)
	LOC102780724	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (825 aa)
	LOC102796920	GLI family zinc finger 1. (917 aa)
	ENSNBRP00000013186	Uncharacterized protein. (1172 aa)
	LOC102776030	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
	LOC102786983	Hedgehog interacting protein. (698 aa)
	LOC102787679	SMAD specific E3 ubiquitin protein ligase 1. (708 aa)
	LOC102784880	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (481 aa)
	LOC102777062	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (517 aa)
	LOC102787292	Cyclin Dx; Belongs to the cyclin family. (296 aa)
	LOC102792316	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (353 aa)
	LOC102788905	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (421 aa)
	ENSNBRP00000010231	Uncharacterized protein. (253 aa)
	LOC102794192	Attractin-like 1a. (1269 aa)
	LOC102798763	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1263 aa)
	LOC102783924	F-box and WD repeat domain containing 11b. (527 aa)
	LOC102797016	Casein kinase 1 delta; Belongs to the protein kinase superfamily. (404 aa)

Your Current Organism:

Neolamprologus brichardi

NCBI taxonomy Id: 32507
Other names: Lamprologus brichardi, N. brichardi, lyretail cichlid

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSNK1D	LOC102778522	ENSNBRP00000030042	ENSNBRP00000003335	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.727
CSNK1D	LOC102779162	ENSNBRP00000030042	ENSNBRP00000015800	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	G kinase anchoring protein 1.	0.558
CSNK1D	LOC102779523	ENSNBRP00000030042	ENSNBRP00000015908	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.854
CSNK1D	LOC102779559	ENSNBRP00000030042	ENSNBRP00000016574	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	GLI family zinc finger 3.	0.584
CSNK1D	LOC102780724	ENSNBRP00000030042	ENSNBRP00000005611	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.859
CSNK1D	LOC102781676	ENSNBRP00000030042	ENSNBRP00000027415	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.584
CSNK1D	LOC102783800	ENSNBRP00000030042	ENSNBRP00000026328	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Casein kinase 1, gamma 1; Belongs to the protein kinase superfamily.	0.561
CSNK1D	LOC102783907	ENSNBRP00000030042	ENSNBRP00000028240	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily.	0.569
CSNK1D	LOC102783924	ENSNBRP00000030042	ENSNBRP00000011401	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	F-box and WD repeat domain containing 11b.	0.851
CSNK1D	LOC102784880	ENSNBRP00000030042	ENSNBRP00000006605	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily.	0.727
CSNK1D	LOC102788905	ENSNBRP00000030042	ENSNBRP00000009169	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily.	0.659
CSNK1D	LOC102790562	ENSNBRP00000030042	ENSNBRP00000001358	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.	0.695
CSNK1D	LOC102790666	ENSNBRP00000030042	ENSNBRP00000024120	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.695
CSNK1D	LOC102792316	ENSNBRP00000030042	ENSNBRP00000008318	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.885
CSNK1D	LOC102794599	ENSNBRP00000030042	ENSNBRP00000013796	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Casein kinase 1, gamma 2b; Belongs to the protein kinase superfamily.	0.682
CSNK1D	LOC102796761	ENSNBRP00000030042	ENSNBRP00000027018	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.695
CSNK1D	LOC102796796	ENSNBRP00000030042	ENSNBRP00000027686	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.584
CSNK1D	LOC102796920	ENSNBRP00000030042	ENSNBRP00000005624	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	GLI family zinc finger 1.	0.584
CSNK1D	LOC102797016	ENSNBRP00000030042	ENSNBRP00000011758	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	0.841
CSNK1D	LOC102797312	ENSNBRP00000030042	ENSNBRP00000021706	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	EvC ciliary complex subunit 1.	0.419