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leuA leuA leuB leuB leuC leuC leuD leuD maeA maeA Sbal_0858 Sbal_0858 oadG oadG Sbal_1025 Sbal_1025 Sbal_1026 Sbal_1026 Sbal_2243 Sbal_2243 Sbal_2294 Sbal_2294 Sbal_2386 Sbal_2386 Sbal_2387 Sbal_2387 Sbal_3841 Sbal_3841 ilvA ilvA ilvD ilvD Sbal_4030 Sbal_4030 Sbal_4031 Sbal_4031 Sbal_4032 Sbal_4032
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (522 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
maeAMalate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: shn:Shewana3_0750 malic enzyme, NAD-binding; Belongs to the malic enzymes family. (562 aa)
Sbal_0858PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: shn:Shewana3_3319 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (329 aa)
oadGSodium pump decarboxylases, gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (100 aa)
Sbal_1025TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: biotin/lipoyl attachment domain-containing protein; pyruvate carboxyltransferase; Conserved carboxylase region; KEGG: she:Shewmr4_2986 oxaloacetate decarboxylase alpha subunit. (606 aa)
Sbal_1026Sodium ion-translocating decarboxylase, beta subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (376 aa)
Sbal_2243PFAM: pyruvate kinase; KEGG: shn:Shewana3_2153 pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
Sbal_2294Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: chu:CHU_2249 pyruvate dehydrogenase (pyruvate oxidase); Belongs to the TPP enzyme family. (578 aa)
Sbal_2386TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: shn:Shewana3_2269 acetolactate synthase, large subunit, biosynthetic type. (572 aa)
Sbal_2387TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: shn:Shewana3_2270 acetolactate synthase, small subunit. (164 aa)
Sbal_3841Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: shn:Shewana3_3669 malic enzyme, NAD-binding. (414 aa)
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (531 aa)
ilvDKEGG: shn:Shewana3_0358 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (624 aa)
Sbal_4030Acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: shn:Shewana3_0357 acetolactate synthase small subunit. (85 aa)
Sbal_4031TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: shn:Shewana3_0356 acetolactate synthase, large subunit, biosynthetic type. (557 aa)
Sbal_4032Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (492 aa)
Your Current Organism:
Shewanella baltica
NCBI taxonomy Id: 325240
Other names: S. baltica OS155, Shewanella baltica OS155, Shewanella baltica str. OS155, Shewanella baltica strain OS155
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