STRINGSTRING
mdh mdh fbp fbp Sbal_0830 Sbal_0830 Sbal_0871 Sbal_0871 Sbal_0985 Sbal_0985 acsA acsA Sbal_1848 Sbal_1848 serC serC Sbal_2418 Sbal_2418 Sbal_2419 Sbal_2419 Sbal_2488 Sbal_2488 ackA ackA Sbal_2675 Sbal_2675 eno eno glyA glyA Sbal_3212 Sbal_3212 torD torD Sbal_3222 Sbal_3222 Sbal_3502 Sbal_3502 Sbal_4027 Sbal_4027 ppc ppc Sbal_4136 Sbal_4136 Sbal_4137 Sbal_4137 Sbal_4138 Sbal_4138 Sbal_4140 Sbal_4140 Sbal_4141 Sbal_4141 Sbal_4142 Sbal_4142 gpmI gpmI
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
fbpPFAM: Inositol phosphatase/fructose-1,6-bisphosphatase; KEGG: shm:Shewmr7_3373 inositol phosphatase/fructose-1,6-bisphosphatase. (342 aa)
Sbal_0830Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (355 aa)
Sbal_0871TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: shm:Shewmr7_3198 formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1425 aa)
Sbal_0985PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: shn:Shewana3_3201 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (317 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa)
Sbal_1848TIGRFAM: alpha-L-glutamate ligases, RimK family; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: son:SO2200 ribosomal protein S6 modification protein, putative; Belongs to the RimK family. (328 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa)
Sbal_2418Carboxylesterase; Serine hydrolase involved in the detoxification of formaldehyde. (280 aa)
Sbal_2419PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: shn:Shewana3_1837 alcohol dehydrogenase, zinc-binding domain protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (379 aa)
Sbal_2488Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (789 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
Sbal_2675Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (717 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (431 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
Sbal_3212TIGRFAM: trimethylamine-N-oxide reductase c-type cytochrome TorC; PFAM: NapC/NirT cytochrome c domain protein; KEGG: shm:Shewmr7_1117 trimethylamine-N-oxide reductase C-type cytochrome TorC; Belongs to the TorC/TorY family. (392 aa)
torDCytoplasmic chaperone TorD family protein; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (209 aa)
Sbal_3222Phosphoserine phosphatase; KEGG: shn:Shewana3_1046 haloacid dehalogenase domain protein hydrolase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. (326 aa)
Sbal_3502D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: son:SO0862 D-3-phosphoglycerate dehydrogenase. (409 aa)
Sbal_4027PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. (377 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (889 aa)
Sbal_4136Formate dehydrogenase alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: she:Shewmr4_3720 twin-arginine translocation pathway signal; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (950 aa)
Sbal_4137PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: shn:Shewana3_3917 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (198 aa)
Sbal_4138TIGRFAM: formate dehydrogenase, gamma subunit; KEGG: shn:Shewana3_3918 formate dehydrogenase, gamma subunit. (342 aa)
Sbal_4140Formate dehydrogenase alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: shm:Shewmr7_3795 twin-arginine translocation pathway signal; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (950 aa)
Sbal_4141PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: shn:Shewana3_3921 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (187 aa)
Sbal_4142TIGRFAM: formate dehydrogenase, gamma subunit; KEGG: shn:Shewana3_3922 formate dehydrogenase, gamma subunit. (327 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa)
Your Current Organism:
Shewanella baltica
NCBI taxonomy Id: 325240
Other names: S. baltica OS155, Shewanella baltica OS155, Shewanella baltica str. OS155, Shewanella baltica strain OS155
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