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fhs fhs folD folD Cagg_0061 Cagg_0061 pyrC pyrC purL purL Cagg_0426 Cagg_0426 Cagg_0631 Cagg_0631 surE surE Cagg_0762 Cagg_0762 Cagg_0852 Cagg_0852 Cagg_1023 Cagg_1023 udk udk Cagg_1469 Cagg_1469 guaA guaA Cagg_1673 Cagg_1673 pyrG pyrG purF purF purA purA gmk gmk Cagg_2135 Cagg_2135 upp upp purC purC purM purM Cagg_2211 Cagg_2211 rsgA rsgA dcd dcd Cagg_2635 Cagg_2635 tilS tilS Cagg_2663 Cagg_2663 purH purH Cagg_2767 Cagg_2767 ndk ndk purQ purQ tmk tmk adk adk Cagg_3055 Cagg_3055 Cagg_3057 Cagg_3057 purK purK purE purE tdk tdk Cagg_3177 Cagg_3177 Cagg_3224 Cagg_3224 Cagg_3238 Cagg_3238 pyrC-2 pyrC-2 pyrB pyrB pyrR pyrR purN purN purD purD guaB guaB glyA glyA Cagg_3562 Cagg_3562 Cagg_3574 Cagg_3574 apt apt Cagg_3727 Cagg_3727 adk-2 adk-2 pyrD pyrD pyrF pyrF pyrE pyrE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fhsPFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: cau:Caur_2634 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (572 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
Cagg_0061Phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; KEGG: cau:Caur_3282 phosphoribosylamine--glycine ligase. (433 aa)
pyrCDihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (330 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (973 aa)
Cagg_0426TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: cau:Caur_3075 thiamine pyrophosphokinase. (213 aa)
Cagg_0631TIGRFAM: LPXTG-motif cell wall anchor domain protein; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: cau:Caur_3261 5'-nucleotidase domain-containing protein; Belongs to the 5'-nucleotidase family. (587 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa)
Cagg_0762Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
Cagg_0852PFAM: Survival protein SurE; KEGG: cau:Caur_3807 stationary-phase survival protein SurE. (260 aa)
Cagg_1023PFAM: ribonucleotide reductase; KEGG: cau:Caur_3331 ribonucleotide-diphosphate reductase subunit beta. (297 aa)
udkTIGRFAM: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: cau:Caur_1702 uridine kinase. (209 aa)
Cagg_1469Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (136 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (513 aa)
Cagg_1673KEGG: cau:Caur_1166 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (465 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (547 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (488 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (209 aa)
Cagg_2135TIGRFAM: xanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cau:Caur_1419 xanthine phosphoribosyltransferase. (204 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
purCPFAM: SAICAR synthetase; KEGG: cau:Caur_1261 phosphoribosylaminoimidazolesuccinocarboxamide synthase. (250 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; KEGG: cau:Caur_1262 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (341 aa)
Cagg_2211PFAM: Colicin V production protein; KEGG: cau:Caur_0965 colicin V production protein. (171 aa)
rsgARibosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (319 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (186 aa)
Cagg_2635Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (355 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (474 aa)
Cagg_2663KEGG: cau:Caur_2039 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa)
purHKEGG: cau:Caur_2058 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. (505 aa)
Cagg_2767Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (820 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (151 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (254 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (225 aa)
adkNucleoside-triphosphate--adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa)
Cagg_3055Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (272 aa)
Cagg_3057KEGG: cau:Caur_2334 hypothetical protein. (259 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (377 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa)
tdkPFAM: thymidine kinase; KEGG: cau:Caur_2309 thymidine kinase. (193 aa)
Cagg_3177KEGG: cau:Caur_0504 adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: adenosine/AMP deaminase. (346 aa)
Cagg_3224PFAM: Inosine/uridine-preferring nucleoside hydrolase; KEGG: cau:Caur_0484 inosine/uridine-preferring nucleoside hydrolase. (319 aa)
Cagg_3238TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase family 3; Pyrimidine nucleoside phosphorylase domain; Glycosyl transferase, family 3-like; KEGG: hau:Haur_4182 pyrimidine-nucleoside phosphorylase. (435 aa)
pyrC-2Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (488 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: cau:Caur_1891 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
pyrRPhosphoribosyltransferase; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. (182 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (205 aa)
purDKEGG: cau:Caur_0629 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. (414 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
Cagg_3562PFAM: PfkB domain protein; KEGG: cau:Caur_3023 ribokinase-like domain-containing protein. (324 aa)
Cagg_3574Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (539 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (173 aa)
Cagg_3727KEGG: cau:Caur_3730 colicin V production protein. (203 aa)
adk-2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (356 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (246 aa)
pyrEPhosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa)
Your Current Organism:
Chloroflexus aggregans
NCBI taxonomy Id: 326427
Other names: C. aggregans DSM 9485, Chloroflexus aggregans DSM 9485, Chloroflexus aggregans MD-66, Chloroflexus aggregans str. DSM 9485, Chloroflexus aggregans strain DSM 9485
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