STRINGSTRING
NIDE0243 NIDE0243 argB argB trpD trpD pheA pheA hisC hisC aroF aroF tyrA tyrA aroA aroA cmk cmk NIDE0425 NIDE0425 aroE aroE aroK aroK NIDE0482 NIDE0482 argD argD argF argF argG argG argH argH NIDE0487 NIDE0487 lysA lysA dapA dapA dapB dapB dapF dapF hisG hisG hisD hisD hisB hisB hisH hisH NIDE0984 NIDE0984 hisA hisA hisF hisF hisI hisI asd asd aroB aroB aroC aroC trpE trpE trpG trpG trpD-2 trpD-2 trpC trpC NIDE2044 NIDE2044 trpF trpF trpB trpB trpA trpA aroQ aroQ aspC aspC argC argC argJ argJ aroF-2 aroF-2 hisZ hisZ pabB pabB NIDE3823 NIDE3823 thrH thrH lysC lysC hom hom
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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NIDE0243Putative Haloacid dehalogenase superfamily hydrolase, subfamily IB, PSPase-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (231 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (298 aa)
trpDAnthranilate phosphoribosyltransferase; Function of strongly homologous gene; enzyme. (355 aa)
pheAP-protein, bifunctional chorismate mutase/prephenate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (358 aa)
hisCHistidinol-phosphate aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa)
aroF3-deoxy-7-phosphoheptulonate synthase; Function of strongly homologous gene; enzyme. (337 aa)
tyrAPrephenate dehydrogenase; Function of strongly homologous gene; enzyme. (298 aa)
aroA3-phosphoshikimate-1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (442 aa)
cmkCytidylate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (232 aa)
NIDE0425Putative Acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (231 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (284 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa)
NIDE0482Membrane protein of unknown function; No homology to any previously reported sequences. (214 aa)
argDAcetylornithine aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (402 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (326 aa)
argGArgininosuccinate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa)
argHArgininosuccinate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (484 aa)
NIDE0487Protein of unknown function; No homology to any previously reported sequences. (100 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa)
hisGATP-phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (233 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)
hisBImidazoleglycerol-phosphate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (201 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa)
NIDE0984Homologs of previously reported genes of unknown function. (246 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (241 aa)
hisFImidazole glycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa)
hisIFused Phosphoribosyl-AMP cyclohydrolase and Phosphoribosyl-ATP diphosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the PRA-CH family. (220 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (385 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (378 aa)
trpEAnthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (498 aa)
trpGAnthranilate synthase, component II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (187 aa)
trpD-2Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa)
trpCIndole-3-glycerol phosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. (274 aa)
NIDE2044Exported protein of unknown function; No homology to any previously reported sequences. (104 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpF family. (210 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (165 aa)
aspCAspartate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (397 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (357 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (403 aa)
aroF-2Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (352 aa)
hisZATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (369 aa)
pabBAminodeoxychorismate synthase, component I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (477 aa)
NIDE3823Putative Diaminopimelate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (311 aa)
thrHHomoserine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (206 aa)
lysCAspartokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartokinase family. (411 aa)
homHomoserine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (437 aa)
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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