STRINGSTRING
lpxC lpxC htrB htrB NIDE2328 NIDE2328 rfaEa rfaEa kdsB kdsB kdsA kdsA kdsD kdsD lpxD lpxD kdsC kdsC NIDE3023 NIDE3023 NIDE3030 NIDE3030 rfaF/gmhB rfaF/gmhB lpxK lpxK waaA waaA lpxB lpxB lpxA lpxA NIDE3291 NIDE3291 NIDE3423 NIDE3423 hddA hddA gmhA gmhA rfaEb rfaEb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxCUDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (308 aa)
htrBLipid A biosynthesis lauroyl acyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (312 aa)
NIDE2328Putative Galactokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (356 aa)
rfaEaD-beta-D-heptose 7-phosphate kinase, domain I of bifunctional protein HldE; Function of strongly homologous gene; enzyme. (354 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (263 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. (273 aa)
kdsDArabinose-5-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SIS family. GutQ/KpsF subfamily. (345 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (360 aa)
kdsC3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (153 aa)
NIDE3023Putative Lipopolysaccharide heptosyltransferase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (347 aa)
NIDE3030Putative Lipopolysaccharide heptosyltransferase II; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (347 aa)
rfaF/gmhBHeptosyltransferase II; Function of strongly homologous gene; enzyme. (563 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (360 aa)
waaA3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (452 aa)
lpxBLipid-A-disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (377 aa)
lpxAAcyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (269 aa)
NIDE3291Putative Glycosyl transferase, family 9; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (344 aa)
NIDE3423Putative D-glycero-D-manno-heptose 1-phosphate guanosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (230 aa)
hddAD-glycero-D-manno-heptose 7-phosphate kinase; Function of strongly homologous gene; enzyme. (342 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (192 aa)
rfaEbD-beta-D-heptose 1-phosphate adenosyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (160 aa)
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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