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NIDE0597 NIDE0597 NIDE0743 NIDE0743 forB forB forC forC forA forA porE porE porC porC porB porB porA porA leuA leuA pycB pycB pycA pycA acyP acyP porB2-C porB2-C forB2 forB2 accD accD ppdK ppdK acsA acsA maeA maeA fumC fumC accB accB accC accC accA accA lpd lpd pykF pykF fadA fadA atoB atoB NIDE3370 NIDE3370 ackA ackA mdh mdh maeA2 maeA2 acsA-2 acsA-2 pdhA pdhA pdhB pdhB NIDE3854 NIDE3854 NIDE3866 NIDE3866 vorB vorB vorA vorA vorCD vorCD pdhC pdhC pdhA-2 pdhA-2 NIDE4062 NIDE4062 NIDE4110 NIDE4110 NIDE4281 NIDE4281 pykA pykA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
NIDE0597Putative Lactoylglutathione lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (132 aa)
NIDE0743Protein of unknown function; No homology to any previously reported sequences. (444 aa)
forB2-oxoglutarate:ferredoxin oxidoredutase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (299 aa)
forC2-oxoglutarate:ferredoxin oxidoredutase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (237 aa)
forA2-oxoglutarate:ferredoxin oxidoredutase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (448 aa)
porEPyruvate:ferredoxin oxidoreductase epsilon subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (92 aa)
porCPyruvate:ferredoxin oxidoreductase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (235 aa)
porBPyruvate:ferredoxin oxidoreductase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (300 aa)
porAPyruvate:ferredoxin oxidoreductase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (403 aa)
leuA2-Isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
pycBPyruvate carboxylase, subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (643 aa)
pycAPyruvate carboxylase, subunit A; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (472 aa)
acyPAcylphosphatase; Function of strongly homologous gene; enzyme. (96 aa)
porB2-CPartial 2-oxoacid:ferredoxin oxidoreductase beta subunit (fragment C-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (240 aa)
forB22-oxoacid:ferredoxin oxidoreductase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (297 aa)
accDAcetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (278 aa)
ppdKPyruvate, phosphate dikinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the PEP-utilizing enzyme family. (949 aa)
acsAAcetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (629 aa)
maeAMalate dehydrogenase (oxaloacetate-decarboxylating); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (480 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (484 aa)
accBAcetyl CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (191 aa)
accCAcetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
accAAcetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa)
lpdDihydrolipoyl dehydrogenase, E3 component of Pyruvate and 2-oxoglutarate dehydrogenase complexes; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (473 aa)
pykFPyruvate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (478 aa)
fadA3-ketoacyl-CoA thiolase; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
atoBAcetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
NIDE3370Putative Hydrolase, beta-lactamase-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (209 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
maeA2NAD-dependent malic enzyme; Function of strongly homologous gene; enzyme. (447 aa)
acsA-2Acetyl-CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (586 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (324 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit (Transketolase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (324 aa)
NIDE3854Putative Pyruvate dehydrogenase complex, dihydrolipoamide acetyltransferase (E2) component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (390 aa)
NIDE3866Putative Acyl-CoA synthetase (NDP forming); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (911 aa)
vorB2-ketoisovalerate ferredoxin reductase, beta subunit; Function of strongly homologous gene; enzyme. (312 aa)
vorA2-ketoisovalerate ferredoxin reductase, alpha subunit; Function of strongly homologous gene; enzyme. (412 aa)
vorCD2-ketoisovalerate ferredoxin reductase, fused gamma and delta subunit; Function of strongly homologous gene; enzyme. (305 aa)
pdhCDihydrolipoamide acetyltransferase (E2) component of pyruvate dehydrogenase complex; Function of strongly homologous gene; enzyme. (400 aa)
pdhA-2Dehydrogenase (E1) component of pyruvate dehydrogenase complex, alpha subunit (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa)
NIDE4062Aldehyde dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the aldehyde dehydrogenase family. (518 aa)
NIDE41102-isopropylmalate/homocitrate synthase-family transferase; Function of strongly homologous gene; enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. (529 aa)
NIDE4281Putative Hydrolase with N-terminal DNA-binding domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (287 aa)
pykAPyruvate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (483 aa)
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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