STRINGSTRING
glyA glyA gcvP gcvP gcvT gcvT ttuD ttuD acnA acnA NIDE1059 NIDE1059 NIDE1160 NIDE1160 glnA glnA acsA acsA rlp rlp fdsB fdsB fdsA fdsA gltA gltA ghrB ghrB lpd lpd gcvH gcvH fadA fadA NIDE3109 NIDE3109 atoB atoB scpAa scpAa scpAb scpAb mdh mdh NIDE3844 NIDE3844 acsA-2 acsA-2 NIDE4061 NIDE4061 NIDE4284 NIDE4284
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
gcvPGlycine dehydrogenase, glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
gcvTAminomethyltransferase, glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (369 aa)
ttuDPutative Hydroxypyruvate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (446 aa)
acnAAconitate hydratase; Function of strongly homologous gene; enzyme. (748 aa)
NIDE1059Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the GcvT family. (363 aa)
NIDE1160Aminotransferase, class V; Function of strongly homologous gene; enzyme. (382 aa)
glnAGlutamine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (469 aa)
acsAAcetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (629 aa)
rlpRibulose bisphosphate carboxylase-like protein (RuBisCO type IV-like protein); Function of strongly homologous gene; enzyme. (370 aa)
fdsBFormate dehydrogenase, beta subunit; Function of strongly homologous gene; enzyme. (498 aa)
fdsAFormate dehydrogenase, alpha subunit; Function of strongly homologous gene; enzyme. (908 aa)
gltACitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. (377 aa)
ghrBGlyoxylate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
lpdDihydrolipoyl dehydrogenase, E3 component of Pyruvate and 2-oxoglutarate dehydrogenase complexes; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (473 aa)
gcvHGlycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
fadA3-ketoacyl-CoA thiolase; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
NIDE3109Putative 4-hydroxyphenylpyruvate dioxygenase (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (198 aa)
atoBAcetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
scpAaMethylmalonyl-CoA mutase (N-terminal fragment); Function of strongly homologous gene; enzyme. (531 aa)
scpAbMethylmalonyl-CoA mutase (C-terminal fragment); Function of strongly homologous gene; enzyme. (135 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
NIDE3844Protein of unknown function; No homology to any previously reported sequences. (166 aa)
acsA-2Acetyl-CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (586 aa)
NIDE4061Protein of unknown function; No homology to any previously reported sequences. (190 aa)
NIDE4284Putative Phosphoglycolate phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (216 aa)
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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