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forB forB forC forC forA forA sucC sucC sucD sucD porE porE porC porC porB porB porA porA porB2-C porB2-C forB2 forB2 accD accD acsA acsA accB accB accC accC accA accA lpd lpd NIDE3103 NIDE3103 fadA fadA NIDE3109 NIDE3109 NIDE3114 NIDE3114 atoB atoB scpAa scpAa scpAb scpAb prpD prpD prpB prpB prpC prpC ackA ackA NIDE3844 NIDE3844 acsA-2 acsA-2 NIDE3866 NIDE3866 vorB vorB vorA vorA vorCD vorCD NIDE4061 NIDE4061
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
forB2-oxoglutarate:ferredoxin oxidoredutase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (299 aa)
forC2-oxoglutarate:ferredoxin oxidoredutase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (237 aa)
forA2-oxoglutarate:ferredoxin oxidoredutase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (448 aa)
sucCSuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
sucDSuccinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
porEPyruvate:ferredoxin oxidoreductase epsilon subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (92 aa)
porCPyruvate:ferredoxin oxidoreductase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (235 aa)
porBPyruvate:ferredoxin oxidoreductase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (300 aa)
porAPyruvate:ferredoxin oxidoreductase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (403 aa)
porB2-CPartial 2-oxoacid:ferredoxin oxidoreductase beta subunit (fragment C-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (240 aa)
forB22-oxoacid:ferredoxin oxidoreductase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (297 aa)
accDAcetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (278 aa)
acsAAcetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (629 aa)
accBAcetyl CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (191 aa)
accCAcetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
accAAcetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa)
lpdDihydrolipoyl dehydrogenase, E3 component of Pyruvate and 2-oxoglutarate dehydrogenase complexes; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (473 aa)
NIDE3103Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (407 aa)
fadA3-ketoacyl-CoA thiolase; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
NIDE3109Putative 4-hydroxyphenylpyruvate dioxygenase (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (198 aa)
NIDE3114Putative 2-oxoisovalerate dehydrogenase, beta subunit (Transketolase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (330 aa)
atoBAcetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
scpAaMethylmalonyl-CoA mutase (N-terminal fragment); Function of strongly homologous gene; enzyme. (531 aa)
scpAbMethylmalonyl-CoA mutase (C-terminal fragment); Function of strongly homologous gene; enzyme. (135 aa)
prpD2-methylcitrate dehydratase; Function of strongly homologous gene; enzyme. (467 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (313 aa)
prpC2-methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. (392 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa)
NIDE3844Protein of unknown function; No homology to any previously reported sequences. (166 aa)
acsA-2Acetyl-CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (586 aa)
NIDE3866Putative Acyl-CoA synthetase (NDP forming); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (911 aa)
vorB2-ketoisovalerate ferredoxin reductase, beta subunit; Function of strongly homologous gene; enzyme. (312 aa)
vorA2-ketoisovalerate ferredoxin reductase, alpha subunit; Function of strongly homologous gene; enzyme. (412 aa)
vorCD2-ketoisovalerate ferredoxin reductase, fused gamma and delta subunit; Function of strongly homologous gene; enzyme. (305 aa)
NIDE4061Protein of unknown function; No homology to any previously reported sequences. (190 aa)
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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