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glyA glyA sdhA sdhA gcvP gcvP gcvT gcvT rpiA rpiA glk glk pgl pgl NIDE0356 NIDE0356 rpe rpe gdhA gdhA zwf1 zwf1 gpmA gpmA talC talC ttuD ttuD prsA prsA folD folD metF metF forB forB forC forC forA forA aclB aclB aclA aclA acnA acnA idh idh sucC sucC sucD sucD porE porE porC porC porB porB porA porA NIDE1059 NIDE1059 tpiA tpiA pgk pgk gapA gapA NIDE1160 NIDE1160 pycB pycB pycA pycA porB2-C porB2-C forB2 forB2 accD accD ppdK ppdK acsA acsA cysK cysK rlp rlp fdsB fdsB fdsA fdsA fbpV fbpV zwf2 zwf2 gnd gnd NIDE2398 NIDE2398 maeA maeA gltA gltA fumC fumC accB accB accC accC sdhB sdhB sdhE sdhE tktA tktA accA accA lpd lpd gcvH gcvH pykF pykF eno eno cysE cysE fbaB fbaB fbp-2 fbp-2 NIDE3103 NIDE3103 fadA fadA NIDE3109 NIDE3109 atoB atoB paaH paaH scpAa scpAa scpAb scpAb pfkA pfkA NIDE3328 NIDE3328 serA serA ackA ackA mdh mdh gntK gntK fhs fhs NIDE3844 NIDE3844 maeA2 maeA2 acsA-2 acsA-2 pdhA pdhA pdhB pdhB NIDE3854 NIDE3854 vorB vorB vorA vorA vorCD vorCD pdhC pdhC pdhA-2 pdhA-2 NIDE4061 NIDE4061 thrH thrH apgM apgM pykA pykA NIDE4287 NIDE4287
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
sdhASuccinate dehydrogenase/fumarate reductase, flavoprotein subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (551 aa)
gcvPGlycine dehydrogenase, glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
gcvTAminomethyltransferase, glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (369 aa)
rpiARibose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (238 aa)
glkGlucokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the bacterial glucokinase family. (361 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (253 aa)
NIDE0356Putative Glucose-6-phosphate isomerase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the GPI family. (567 aa)
rpeD-ribulose-5-phosphate 3-epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribulose-phosphate 3-epimerase family. (234 aa)
gdhAGlutamate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (419 aa)
zwf1Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (509 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (201 aa)
talCTransaldolase, putative Fructose-6-phosphate aldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa)
ttuDPutative Hydroxypyruvate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (446 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa)
folDBifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
metF5,10-methylenetetrahydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
forB2-oxoglutarate:ferredoxin oxidoredutase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (299 aa)
forC2-oxoglutarate:ferredoxin oxidoredutase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (237 aa)
forA2-oxoglutarate:ferredoxin oxidoredutase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (448 aa)
aclBATP-citrate lyase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (399 aa)
aclAATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (606 aa)
acnAAconitate hydratase; Function of strongly homologous gene; enzyme. (748 aa)
idhIsocitrate dehydrogenase (NADP(+)); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the monomeric-type IDH family. (743 aa)
sucCSuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
sucDSuccinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
porEPyruvate:ferredoxin oxidoreductase epsilon subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (92 aa)
porCPyruvate:ferredoxin oxidoreductase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (235 aa)
porBPyruvate:ferredoxin oxidoreductase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (300 aa)
porAPyruvate:ferredoxin oxidoreductase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (403 aa)
NIDE1059Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the GcvT family. (363 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (259 aa)
pgkPhosphoglycerate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phosphoglycerate kinase family. (399 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
NIDE1160Aminotransferase, class V; Function of strongly homologous gene; enzyme. (382 aa)
pycBPyruvate carboxylase, subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (643 aa)
pycAPyruvate carboxylase, subunit A; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (472 aa)
porB2-CPartial 2-oxoacid:ferredoxin oxidoreductase beta subunit (fragment C-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (240 aa)
forB22-oxoacid:ferredoxin oxidoreductase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (297 aa)
accDAcetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (278 aa)
ppdKPyruvate, phosphate dikinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the PEP-utilizing enzyme family. (949 aa)
acsAAcetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (629 aa)
cysKCysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (309 aa)
rlpRibulose bisphosphate carboxylase-like protein (RuBisCO type IV-like protein); Function of strongly homologous gene; enzyme. (370 aa)
fdsBFormate dehydrogenase, beta subunit; Function of strongly homologous gene; enzyme. (498 aa)
fdsAFormate dehydrogenase, alpha subunit; Function of strongly homologous gene; enzyme. (908 aa)
fbpVFructose-1,6-bisphosphatase, class V; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (370 aa)
zwf2Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa)
gnd6-phosphogluconate dehydrogenase (decarboxylating); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (297 aa)
NIDE2398Putative Serine acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (150 aa)
maeAMalate dehydrogenase (oxaloacetate-decarboxylating); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (480 aa)
gltACitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. (377 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (484 aa)
accBAcetyl CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (191 aa)
accCAcetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
sdhBSuccinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (324 aa)
sdhESuccinate dehydrogenase, subunit C; Function of strongly homologous gene; enzyme. (300 aa)
tktATransketolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (628 aa)
accAAcetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa)
lpdDihydrolipoyl dehydrogenase, E3 component of Pyruvate and 2-oxoglutarate dehydrogenase complexes; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (473 aa)
gcvHGlycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
pykFPyruvate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (478 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
cysESerine O-acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (216 aa)
fbaBFructose-bisphosphate aldolase class I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (307 aa)
fbp-2Fructose-1-6-bisphosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FBPase class 1 family. (332 aa)
NIDE3103Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (407 aa)
fadA3-ketoacyl-CoA thiolase; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
NIDE3109Putative 4-hydroxyphenylpyruvate dioxygenase (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (198 aa)
atoBAcetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
paaH3-hydroxybutyryl-CoA dehydrogenase; Function of strongly homologous gene; enzyme. (294 aa)
scpAaMethylmalonyl-CoA mutase (N-terminal fragment); Function of strongly homologous gene; enzyme. (531 aa)
scpAbMethylmalonyl-CoA mutase (C-terminal fragment); Function of strongly homologous gene; enzyme. (135 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (421 aa)
NIDE3328Putative Serine O-acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (192 aa)
serAD-3-phosphoglycerate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
gntKGluconate kinase (fragment); Function of strongly homologous gene; enzyme. (125 aa)
fhsFormate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. (560 aa)
NIDE3844Protein of unknown function; No homology to any previously reported sequences. (166 aa)
maeA2NAD-dependent malic enzyme; Function of strongly homologous gene; enzyme. (447 aa)
acsA-2Acetyl-CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (586 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (324 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit (Transketolase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (324 aa)
NIDE3854Putative Pyruvate dehydrogenase complex, dihydrolipoamide acetyltransferase (E2) component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (390 aa)
vorB2-ketoisovalerate ferredoxin reductase, beta subunit; Function of strongly homologous gene; enzyme. (312 aa)
vorA2-ketoisovalerate ferredoxin reductase, alpha subunit; Function of strongly homologous gene; enzyme. (412 aa)
vorCD2-ketoisovalerate ferredoxin reductase, fused gamma and delta subunit; Function of strongly homologous gene; enzyme. (305 aa)
pdhCDihydrolipoamide acetyltransferase (E2) component of pyruvate dehydrogenase complex; Function of strongly homologous gene; enzyme. (400 aa)
pdhA-2Dehydrogenase (E1) component of pyruvate dehydrogenase complex, alpha subunit (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa)
NIDE4061Protein of unknown function; No homology to any previously reported sequences. (190 aa)
thrHHomoserine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (206 aa)
apgM2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Function of strongly homologous gene; enzyme. (416 aa)
pykAPyruvate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (483 aa)
NIDE4287Putative 6-phosphofructokinase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (779 aa)
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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