STRINGSTRING
CDL18_02840 CDL18_02840 GCA_900067245_03802 GCA_900067245_03802 rpmB rpmB CDL27_00895 CDL27_00895 ispH ispH GCA_900067245_03615 GCA_900067245_03615 CDL18_13535 CDL18_13535 CDL18_13530 CDL18_13530 CDL18_13525 CDL18_13525 rpsU rpsU recN recN CDL27_01680 CDL27_01680 GCA_900067245_03377 GCA_900067245_03377 rpsO rpsO CDL18_08030 CDL18_08030 CDL24_08830 CDL24_08830 CDL20_06485 CDL20_06485 rpsT rpsT CDL25_03425 CDL25_03425 topB-2 topB-2 GCA_900067245_03161 GCA_900067245_03161 GCA_900067245_03077 GCA_900067245_03077 GCA_900067245_03075 GCA_900067245_03075 recO recO priA priA rplS rplS rimM rimM rpsP rpsP CDL18_12045 CDL18_12045 CDL25_05895 CDL25_05895 CDL18_12030 CDL18_12030 pduC pduC rplQ rplQ rpsD rpsD rpsK rpsK rpsM rpsM CDL25_11650 CDL25_11650 rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsZ rpsZ rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ rpsG rpsG rpsL rpsL glgD glgD glgC glgC CDL24_03315 CDL24_03315 CDL18_08620 CDL18_08620 rplL rplL rplJ rplJ rplA rplA rplK rplK GCA_900067245_02378 GCA_900067245_02378 CDL25_14245 CDL25_14245 rplI rplI rpsR rpsR rpsF rpsF recR recR CDL18_04655 CDL18_04655 GCA_900067245_02058 GCA_900067245_02058 GCA_900067245_02027 GCA_900067245_02027 GCA_900067245_01951 GCA_900067245_01951 CDL18_12625 CDL18_12625 CDL18_12630 CDL18_12630 rpmH rpmH gyrB gyrB gyrA gyrA CDL27_15195 CDL27_15195 recQ recQ CDL27_11745 CDL27_11745 GCA_900067245_01619 GCA_900067245_01619 GCA_900067245_01570 GCA_900067245_01570 rplM rplM rpsI rpsI GCA_900067245_01355 GCA_900067245_01355 GCA_900067245_01345 GCA_900067245_01345 topB topB pduB pduB CDL18_07515 CDL18_07515 CDL18_07520 CDL18_07520 CDL18_07525 CDL18_07525 CDL18_07530 CDL18_07530 CDL18_07535 CDL18_07535 CDL18_07540 CDL18_07540 CDL18_07550 CDL18_07550 topA topA rpsB rpsB GCA_900067245_00973 GCA_900067245_00973 GCA_900067245_00911 GCA_900067245_00911 CDL27_01450 CDL27_01450 GCA_900067245_00852 GCA_900067245_00852 CDL18_01850 CDL18_01850 CDL27_16155 CDL27_16155 GCA_900067245_00666 GCA_900067245_00666 CDL27_08185 CDL27_08185 CDL24_01210 CDL24_01210 CDL25_00995 CDL25_00995 rpmE rpmE rpmI rpmI rplT rplT dnaG dnaG rpmF rpmF smc smc GCA_900067245_00217 GCA_900067245_00217 CDL27_00330 CDL27_00330 rpmA rpmA rplU rplU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDL18_02840Unannotated protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (447 aa)
GCA_900067245_03802Unannotated protein. (295 aa)
rpmBUnannotated protein; Belongs to the bacterial ribosomal protein bL28 family. (61 aa)
CDL27_00895Unannotated protein. (358 aa)
ispHUnannotated protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (284 aa)
GCA_900067245_03615Unannotated protein. (257 aa)
CDL18_13535Unannotated protein. (121 aa)
CDL18_13530Unannotated protein. (142 aa)
CDL18_13525Unannotated protein; Belongs to the EutP/PduV family. (175 aa)
rpsUUnannotated protein; Belongs to the bacterial ribosomal protein bS21 family. (58 aa)
recNUnannotated protein; May be involved in recombinational repair of damaged DNA. (557 aa)
CDL27_01680Unannotated protein. (275 aa)
GCA_900067245_03377Unannotated protein. (236 aa)
rpsOUnannotated protein; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (88 aa)
CDL18_08030Unannotated protein. (107 aa)
CDL24_08830Unannotated protein. (747 aa)
CDL20_06485Unannotated protein. (640 aa)
rpsTUnannotated protein; Binds directly to 16S ribosomal RNA. (87 aa)
CDL25_03425Unannotated protein. (353 aa)
topB-2Unannotated protein. (669 aa)
GCA_900067245_03161Unannotated protein. (295 aa)
GCA_900067245_03077Unannotated protein. (362 aa)
GCA_900067245_03075Unannotated protein. (257 aa)
recOUnannotated protein; Involved in DNA repair and RecF pathway recombination. (246 aa)
priAUnannotated protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (742 aa)
rplSUnannotated protein; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa)
rimMUnannotated protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (172 aa)
rpsPUnannotated protein; Belongs to the bacterial ribosomal protein bS16 family. (81 aa)
CDL18_12045Unannotated protein. (109 aa)
CDL25_05895Unannotated protein. (130 aa)
CDL18_12030Unannotated protein. (222 aa)
pduCUnannotated protein. (554 aa)
rplQUnannotated protein. (176 aa)
rpsDUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (197 aa)
rpsKUnannotated protein; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (131 aa)
rpsMUnannotated protein; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (122 aa)
CDL25_11650Unannotated protein. (81 aa)
rplOUnannotated protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpmDUnannotated protein. (60 aa)
rpsEUnannotated protein; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (169 aa)
rplRUnannotated protein; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (122 aa)
rplFUnannotated protein; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (180 aa)
rpsHUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (133 aa)
rpsZUnannotated protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplEUnannotated protein; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rplXUnannotated protein; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (103 aa)
rplNUnannotated protein; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQUnannotated protein; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (85 aa)
rpmCUnannotated protein; Belongs to the universal ribosomal protein uL29 family. (68 aa)
rplPUnannotated protein; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (145 aa)
rpsCUnannotated protein; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa)
rplVUnannotated protein; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (128 aa)
rpsSUnannotated protein; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplBUnannotated protein; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (280 aa)
rplWUnannotated protein; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (99 aa)
rplDUnannotated protein; Forms part of the polypeptide exit tunnel. (206 aa)
rplCUnannotated protein; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (227 aa)
rpsJUnannotated protein; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (105 aa)
rpsGUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsLUnannotated protein; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (139 aa)
glgDUnannotated protein; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (372 aa)
glgCUnannotated protein; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (424 aa)
CDL24_03315Unannotated protein. (354 aa)
CDL18_08620Unannotated protein; Belongs to the DnaA family. (332 aa)
rplLUnannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (125 aa)
rplJUnannotated protein; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (181 aa)
rplAUnannotated protein; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa)
rplKUnannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
GCA_900067245_02378Unannotated protein. (276 aa)
CDL25_14245Unannotated protein. (285 aa)
rplIUnannotated protein; Binds to the 23S rRNA. (148 aa)
rpsRUnannotated protein; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (88 aa)
rpsFUnannotated protein; Binds together with S18 to 16S ribosomal RNA. (95 aa)
recRUnannotated protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
CDL18_04655Unannotated protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (117 aa)
GCA_900067245_02058Unannotated protein. (257 aa)
GCA_900067245_02027Unannotated protein. (322 aa)
GCA_900067245_01951Unannotated protein. (104 aa)
CDL18_12625Unannotated protein. (159 aa)
CDL18_12630Unannotated protein; Belongs to the ParB family. (302 aa)
rpmHUnannotated protein; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
gyrBUnannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (645 aa)
gyrAUnannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (837 aa)
CDL27_15195Unannotated protein. (398 aa)
recQUnannotated protein. (753 aa)
CDL27_11745Unannotated protein. (159 aa)
GCA_900067245_01619Unannotated protein. (125 aa)
GCA_900067245_01570Unannotated protein. (257 aa)
rplMUnannotated protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpsIUnannotated protein; Belongs to the universal ribosomal protein uS9 family. (130 aa)
GCA_900067245_01355Unannotated protein. (217 aa)
GCA_900067245_01345Unannotated protein. (257 aa)
topBUnannotated protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (730 aa)
pduBUnannotated protein. (241 aa)
CDL18_07515Unannotated protein. (117 aa)
CDL18_07520Unannotated protein. (93 aa)
CDL18_07525Unannotated protein. (94 aa)
CDL18_07530Unannotated protein. (151 aa)
CDL18_07535Unannotated protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (216 aa)
CDL18_07540Unannotated protein. (88 aa)
CDL18_07550Unannotated protein. (182 aa)
topAUnannotated protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (690 aa)
rpsBUnannotated protein; Belongs to the universal ribosomal protein uS2 family. (249 aa)
GCA_900067245_00973Unannotated protein. (323 aa)
GCA_900067245_00911Unannotated protein. (278 aa)
CDL27_01450Unannotated protein. (337 aa)
GCA_900067245_00852Unannotated protein. (287 aa)
CDL18_01850Unannotated protein. (99 aa)
CDL27_16155Unannotated protein. (95 aa)
GCA_900067245_00666Unannotated protein. (323 aa)
CDL27_08185Unannotated protein. (325 aa)
CDL24_01210Unannotated protein. (231 aa)
CDL25_00995Unannotated protein. (438 aa)
rpmEUnannotated protein; Binds the 23S rRNA. (66 aa)
rpmIUnannotated protein; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
rplTUnannotated protein; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa)
dnaGUnannotated protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (591 aa)
rpmFUnannotated protein; Belongs to the bacterial ribosomal protein bL32 family. (59 aa)
smcUnannotated protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1185 aa)
GCA_900067245_00217Unannotated protein. (126 aa)
CDL27_00330Unannotated protein. (262 aa)
rpmAUnannotated protein; Belongs to the bacterial ribosomal protein bL27 family. (94 aa)
rplUUnannotated protein; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
Your Current Organism:
Ruminococcus gnavus
NCBI taxonomy Id: 33038
Other names: ATCC 29149, VPI C7-9, [. gnavus, [Ruminococcus] gnavus
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