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| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | gltB | Ferredoxin-dependent glutamate synthase 1. (1507 aa) |
| | gltD_2 | Glutamate synthase [NADPH] small chain. (499 aa) |
| | asnA | Aspartate--ammonia ligase. (336 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (291 aa) |
| | asnB_1 | Asparagine synthetase [glutamine-hydrolyzing] 1. (626 aa) |
| | purF | Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa) |
| | mtnN | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | lysA_2 | Diaminopimelate decarboxylase. (423 aa) |
| | tdcB | L-threonine dehydratase catabolic TdcB. (404 aa) |
| | glyA | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase. (1251 aa) |
| | CUQ81864.1 | IMP cyclohydrolase. (237 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH. (392 aa) |
| | ybbW | Allantoin transport protein. (485 aa) |
| | hyuA | D-phenylhydantoinase. (463 aa) |
| | argH | Argininosuccinate lyase. (459 aa) |
| | asd2 | Aspartate-semialdehyde dehydrogenase 2; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa) |
| | thrC | Threonine synthase. (495 aa) |
| | aroA1 | 3-phosphoshikimate 1-carboxyvinyltransferase 1; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | ypeA | Acetyltransferase YpeA. (148 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (300 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa) |
| | ltaE | Low specificity L-threonine aldolase. (341 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase%2C Phe-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (343 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain. (146 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | pheA | P-protein. (380 aa) |
| | gmk_1 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (211 aa) |
| | sdhA | L-serine dehydratase%2C alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (289 aa) |
| | sdhB | L-serine dehydratase%2C beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (222 aa) |
| | glnA_1 | Glutamine synthetase. (704 aa) |
| | luxS | S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (155 aa) |
| | CUQ84924.1 | Uncharacterised protein. (456 aa) |
| | ydiM | Inner membrane transport protein ydiM. (421 aa) |
| | aroE_1 | Shikimate dehydrogenase. (291 aa) |
| | CUQ84939.1 | NADH oxidase. (656 aa) |
| | CUQ84943.1 | Xylose isomerase-like TIM barrel. (278 aa) |
| | gltC_1 | HTH-type transcriptional regulator gltC. (295 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (330 aa) |
| | metK_1 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa) |
| | aroK_1 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) |
| | hom_1 | Homoserine dehydrogenase. (425 aa) |
| | guaD | Guanine deaminase. (424 aa) |
| | arcC1_1 | Carbamate kinase 1; Belongs to the carbamate kinase family. (314 aa) |
| | xanQ | Xanthine permease XanQ. (480 aa) |
| | proB | Glutamate 5-kinase 1; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (265 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa) |
| | hom_2 | Homoserine dehydrogenase. (405 aa) |
| | ddh | Meso-diaminopimelate D-dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (328 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (353 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase. (337 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (374 aa) |
| | carB | Carbamoyl-phosphate synthase large chain. (1067 aa) |
| | CUQ87592.1 | Xanthine permease. (73 aa) |
| | mdeA_1 | Methionine gamma-lyase. (425 aa) |
| | fhs | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (556 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa) |
| | pyrK_1 | Dihydrdoorotate oxidase B%2C electron transfer subunit. (295 aa) |
| | gltD_4 | Glutamate synthase [NADPH] small chain. (462 aa) |
| | thrA | Aspartokinase I/homoserine dehydrogenase I; Belongs to the aspartokinase family. (439 aa) |
| | icd | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (398 aa) |
| | serA_1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (387 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (370 aa) |
| | yfkN_1 | Trifunctional nucleotide phosphoesterase protein YfkN precursor; Belongs to the 5'-nucleotidase family. (649 aa) |
| | asnB_2 | Asparagine synthetase [glutamine-hydrolyzing] 1. (512 aa) |
| | lysC | Aspartokinase 2; Belongs to the aspartokinase family. (400 aa) |
| | gdhA | NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa) |
| | CUQ89006.1 | Iron hydrogenase 1. (503 aa) |
| | metH | Methionine synthase. (798 aa) |
| | CUQ89016.1 | Vitamin B12 dependent methionine synthase%2C activation domain. (216 aa) |
| | metF | 5%2C10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (289 aa) |
| | dapE_3 | Succinyl-diaminopimelate desuccinylase. (408 aa) |
| | CUQ89314.1 | Aspartate aminotransferase. (498 aa) |
| | udk | Uridine kinase. (573 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (306 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (426 aa) |
| | cysE | Serine acetyltransferase. (231 aa) |
| | dapA_1 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | proA_1 | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (422 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (197 aa) |
| | dapL | LL-diaminopimelate aminotransferase. (400 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (208 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (341 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (226 aa) |
| | pyrD | Dihydroorotate dehydrogenase B (NAD(+))%2C catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (300 aa) |
| | pyrK_2 | Dihydrdoorotate oxidase B%2C electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (260 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (309 aa) |
| | gltD_5 | Glutamate synthase [NADPH] small chain. (408 aa) |
| | dapA_2 | Dihydrodipicolinate synthase; Belongs to the DapA family. (295 aa) |
| | arcC1_2 | Carbamate kinase 1; Belongs to the carbamate kinase family. (309 aa) |
| | glnA_2 | Glutamine synthetase. (444 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa) |
| | CUQ91742.1 | Phosphoserine phosphatase. (200 aa) |
| | guaA_1 | GMP synthase [glutamine-hydrolyzing]. (515 aa) |
| | patB | Cystathionine beta-lyase PatB. (397 aa) |
| | metC | Cystathionine beta-lyase metC. (131 aa) |
| | yfkN_2 | Trifunctional nucleotide phosphoesterase protein YfkN precursor; Belongs to the 5'-nucleotidase family. (620 aa) |
| | aroE_2 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (291 aa) |
| | aroK_2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (261 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (509 aa) |
| | pabA | Para-aminobenzoate synthase glutamine amidotransferase component II. (208 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (226 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (372 aa) |
| | aroE_3 | Shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (104 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (253 aa) |
| | udp_2 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (260 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | gmk_3 | Guanylate kinase. (194 aa) |
| | CUQ93278.1 | Adenine deaminase. (328 aa) |
| | punA | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (270 aa) |
| | cysK | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa) |
| | mdeA_2 | Methionine gamma-lyase. (435 aa) |
| | metB | Cystathionine gamma-synthase. (243 aa) |
