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guaB guaB gltB gltB gltD_2 gltD_2 purC purC purF purF purB purB glyA glyA purL purL CUQ81864.1 CUQ81864.1 purH purH ybbW ybbW hyuA hyuA argH argH argG argG argC argC ypeA ypeA argJ argJ argB argB argD argD pyrI pyrI pyrB pyrB gmk_1 gmk_1 glnA_1 glnA_1 CUQ84924.1 CUQ84924.1 argF argF guaD guaD arcC1_1 arcC1_1 xanQ xanQ proB proB carA carA carB carB CUQ87592.1 CUQ87592.1 fhs fhs folD folD pyrK_1 pyrK_1 gltD_4 gltD_4 icd icd yfkN_1 yfkN_1 gdhA gdhA dapE_3 dapE_3 CUQ89314.1 CUQ89314.1 udk udk purA purA proA_1 proA_1 pyrC pyrC proC proC xpt xpt purD purD purN purN purM purM purE purE pyrE pyrE pyrD pyrD pyrK_2 pyrK_2 pyrF pyrF gltD_5 gltD_5 arcC1_2 arcC1_2 glnA_2 glnA_2 guaA_1 guaA_1 yfkN_2 yfkN_2 udp_2 udp_2 upp upp gmk_3 gmk_3 CUQ93278.1 CUQ93278.1 punA punA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
gltBFerredoxin-dependent glutamate synthase 1. (1507 aa)
gltD_2Glutamate synthase [NADPH] small chain. (499 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (291 aa)
purFAmidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
glyAPyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa)
purLPhosphoribosylformylglycinamidine synthase. (1251 aa)
CUQ81864.1IMP cyclohydrolase. (237 aa)
purHBifunctional purine biosynthesis protein PurH. (392 aa)
ybbWAllantoin transport protein. (485 aa)
hyuAD-phenylhydantoinase. (463 aa)
argHArgininosuccinate lyase. (459 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
ypeAAcetyltransferase YpeA. (148 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (300 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa)
pyrIAspartate carbamoyltransferase regulatory chain. (146 aa)
pyrBAspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
gmk_1Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (211 aa)
glnA_1Glutamine synthetase. (704 aa)
CUQ84924.1Uncharacterised protein. (456 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (330 aa)
guaDGuanine deaminase. (424 aa)
arcC1_1Carbamate kinase 1; Belongs to the carbamate kinase family. (314 aa)
xanQXanthine permease XanQ. (480 aa)
proBGlutamate 5-kinase 1; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (265 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (374 aa)
carBCarbamoyl-phosphate synthase large chain. (1067 aa)
CUQ87592.1Xanthine permease. (73 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa)
pyrK_1Dihydrdoorotate oxidase B%2C electron transfer subunit. (295 aa)
gltD_4Glutamate synthase [NADPH] small chain. (462 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (398 aa)
yfkN_1Trifunctional nucleotide phosphoesterase protein YfkN precursor; Belongs to the 5'-nucleotidase family. (649 aa)
gdhANADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa)
dapE_3Succinyl-diaminopimelate desuccinylase. (408 aa)
CUQ89314.1Aspartate aminotransferase. (498 aa)
udkUridine kinase. (573 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (426 aa)
proA_1Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (422 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (197 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (208 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (341 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (226 aa)
pyrDDihydroorotate dehydrogenase B (NAD(+))%2C catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (300 aa)
pyrK_2Dihydrdoorotate oxidase B%2C electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (260 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (309 aa)
gltD_5Glutamate synthase [NADPH] small chain. (408 aa)
arcC1_2Carbamate kinase 1; Belongs to the carbamate kinase family. (309 aa)
glnA_2Glutamine synthetase. (444 aa)
guaA_1GMP synthase [glutamine-hydrolyzing]. (515 aa)
yfkN_2Trifunctional nucleotide phosphoesterase protein YfkN precursor; Belongs to the 5'-nucleotidase family. (620 aa)
udp_2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (260 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
gmk_3Guanylate kinase. (194 aa)
CUQ93278.1Adenine deaminase. (328 aa)
punAPurine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (270 aa)
Your Current Organism:
Ruminococcus torques
NCBI taxonomy Id: 33039
Other names: ATCC 27756, [. torques, [Ruminococcus] torques
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