STRINGSTRING
guaB guaB purC purC purF purF purB purB glyA glyA purL purL CUQ81864.1 CUQ81864.1 purH purH ybbW ybbW hyuA hyuA pyrI pyrI pyrB pyrB CUQ84924.1 CUQ84924.1 xanQ xanQ carA carA carB carB CUQ87592.1 CUQ87592.1 fhs fhs folD folD purA purA pyrC pyrC purD purD purN purN purM purM purE purE pyrE pyrE pyrD pyrD pyrK_2 pyrK_2 pyrF pyrF guaA_1 guaA_1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (291 aa)
purFAmidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
glyAPyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa)
purLPhosphoribosylformylglycinamidine synthase. (1251 aa)
CUQ81864.1IMP cyclohydrolase. (237 aa)
purHBifunctional purine biosynthesis protein PurH. (392 aa)
ybbWAllantoin transport protein. (485 aa)
hyuAD-phenylhydantoinase. (463 aa)
pyrIAspartate carbamoyltransferase regulatory chain. (146 aa)
pyrBAspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
CUQ84924.1Uncharacterised protein. (456 aa)
xanQXanthine permease XanQ. (480 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (374 aa)
carBCarbamoyl-phosphate synthase large chain. (1067 aa)
CUQ87592.1Xanthine permease. (73 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (426 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (422 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (208 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (341 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (226 aa)
pyrDDihydroorotate dehydrogenase B (NAD(+))%2C catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (300 aa)
pyrK_2Dihydrdoorotate oxidase B%2C electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (260 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (309 aa)
guaA_1GMP synthase [glutamine-hydrolyzing]. (515 aa)
Your Current Organism:
Ruminococcus torques
NCBI taxonomy Id: 33039
Other names: ATCC 27756, [. torques, [Ruminococcus] torques
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