(66 nodes) Purine nucleotide metabolic process network (Ruminococcus torques)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

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Your Input:
	atpA_2	V-type ATP synthase alpha chain. (589 aa)
	CUQ92723.1	V-type ATP synthase subunit K. (146 aa)
	CUQ92716.1	V-type ATP synthase subunit E. (195 aa)
	ntpB_2	V-type sodium pump subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (461 aa)
	atpD_2	V-ATPase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (209 aa)
	pfkA_2	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (339 aa)
	rsh	GTP pyrophosphokinase rsh. (329 aa)
	ywaC_2	GTP pyrophosphokinase ywaC. (262 aa)
	guaA_2	GMP synthase [glutamine-hydrolyzing]. (70 aa)
	guaA_1	GMP synthase [glutamine-hydrolyzing]. (515 aa)
	atpB	F-ATPase subunit 6; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (248 aa)
	atpE	Lipid-binding protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (74 aa)
	atpF	F-type ATPase subunit b. (156 aa)
	atpH	F-type ATPase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa)
	atpA_1	ATP synthase subunit alpha. (502 aa)
	atpG	Na(+)-translocating ATPase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (296 aa)
	atpD_1	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (464 aa)
	atpC	F-ATPase epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa)
	atpE-2	V-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (200 aa)
	ntpG	V-type sodium pump subunit G. (108 aa)
	ntpA	V-type sodium ATPase catalytic subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (588 aa)
	ntpB_1	V-type sodium pump subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (457 aa)
	ntpD	V-type sodium pump subunit D. (220 aa)
	purE	N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa)
	purM	Phosphoribosylformylglycinamidine cyclo-ligase. (341 aa)
	purN	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (208 aa)
	purD	Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa)
	xpt	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (197 aa)
	spoT	Bifunctional (p)ppGpp synthase/hydrolase SpoT. (172 aa)
	bacD	Alanine-anticapsin ligase BacD. (405 aa)
	CUQ90352.1	Nitrous oxide-stimulated promoter. (113 aa)
	eno_2	Enolase. (232 aa)
	purA	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (426 aa)
	pgi	Glucose-6-phosphate isomerase; Belongs to the GPI family. (526 aa)
	pfp	Pyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (417 aa)
	accD5	Probable propionyl-CoA carboxylase beta chain 5. (479 aa)
	coaD	Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (163 aa)
	folD	Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa)
	accC	Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
	accD	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (572 aa)
	adk	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
	ywaC_1	GTP pyrophosphokinase ywaC. (258 aa)
	CUQ86270.1	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase. (254 aa)
	relA	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (767 aa)
	hpt	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa)
	gmk_2	Guanylate kinase. (224 aa)
	coaX	Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa)
	coaBC	DNA/pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa)
	pfkA_1	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (359 aa)
	gmk_1	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (211 aa)
	eno_1	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
	CUQ82526.1	Nitrous oxide-stimulated promoter. (112 aa)
	purH	Bifunctional purine biosynthesis protein PurH. (392 aa)
	CUQ81864.1	IMP cyclohydrolase. (237 aa)
	purL	Phosphoribosylformylglycinamidine synthase. (1251 aa)
	ackA	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
	coaE	Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (194 aa)
	pyk	Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
	gpmI	2%2C3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa)
	tpiA	Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
	pgk	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa)
	purB	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
	purF	Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa)
	dacA	DNA integrity scanning protein DisA; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (288 aa)
	purC	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (291 aa)
	guaB	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)

Your Current Organism:

Ruminococcus torques

NCBI taxonomy Id: 33039
Other names: ATCC 27756, [. torques, [Ruminococcus] torques

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUQ81864.1	guaB	ERS852502_00363	ERS852502_00100	IMP cyclohydrolase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.910
CUQ81864.1	hpt	ERS852502_00363	ERS852502_01099	IMP cyclohydrolase.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.900
CUQ81864.1	purA	ERS852502_00363	ERS852502_01972	IMP cyclohydrolase.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.900
CUQ81864.1	purH	ERS852502_00363	ERS852502_00364	IMP cyclohydrolase.	Bifunctional purine biosynthesis protein PurH.	0.994
CUQ81864.1	purL	ERS852502_00363	ERS852502_00343	IMP cyclohydrolase.	Phosphoribosylformylglycinamidine synthase.	0.622
CUQ81864.1	purN	ERS852502_00363	ERS852502_02352	IMP cyclohydrolase.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.887
CUQ92716.1	CUQ92723.1	ERS852502_02693	ERS852502_02695	V-type ATP synthase subunit E.	V-type ATP synthase subunit K.	0.993
CUQ92716.1	atpA_2	ERS852502_02693	ERS852502_02692	V-type ATP synthase subunit E.	V-type ATP synthase alpha chain.	0.996
CUQ92716.1	atpD_2	ERS852502_02693	ERS852502_02690	V-type ATP synthase subunit E.	V-ATPase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.998
CUQ92716.1	atpE	ERS852502_02693	ERS852502_02398	V-type ATP synthase subunit E.	Lipid-binding protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.	0.933
CUQ92716.1	ntpA	ERS852502_02693	ERS852502_02372	V-type ATP synthase subunit E.	V-type sodium ATPase catalytic subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	0.983
CUQ92716.1	ntpB_1	ERS852502_02693	ERS852502_02371	V-type ATP synthase subunit E.	V-type sodium pump subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.	0.984
CUQ92716.1	ntpB_2	ERS852502_02693	ERS852502_02691	V-type ATP synthase subunit E.	V-type sodium pump subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.	0.996
CUQ92716.1	ntpD	ERS852502_02693	ERS852502_02370	V-type ATP synthase subunit E.	V-type sodium pump subunit D.	0.983
CUQ92716.1	ntpG	ERS852502_02693	ERS852502_02373	V-type ATP synthase subunit E.	V-type sodium pump subunit G.	0.975
CUQ92723.1	CUQ92716.1	ERS852502_02695	ERS852502_02693	V-type ATP synthase subunit K.	V-type ATP synthase subunit E.	0.993
CUQ92723.1	adk	ERS852502_02695	ERS852502_01474	V-type ATP synthase subunit K.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.656
CUQ92723.1	atpA_1	ERS852502_02695	ERS852502_02395	V-type ATP synthase subunit K.	ATP synthase subunit alpha.	0.988
CUQ92723.1	atpA_2	ERS852502_02695	ERS852502_02692	V-type ATP synthase subunit K.	V-type ATP synthase alpha chain.	0.992
CUQ92723.1	atpB	ERS852502_02695	ERS852502_02399	V-type ATP synthase subunit K.	F-ATPase subunit 6; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family.	0.992