STRINGSTRING
frdB frdB CUQ80548.1 CUQ80548.1 CUQ80621.1 CUQ80621.1 CUQ80628.1 CUQ80628.1 gltD_1 gltD_1 pflA_1 pflA_1 guaB guaB gltB gltB gltD_2 gltD_2 mop mop CUQ80814.1 CUQ80814.1 spxA spxA fabG_1 fabG_1 algD algD ydbD ydbD gap gap maeB maeB ispG ispG CUQ81839.1 CUQ81839.1 nifH1_1 nifH1_1 CUQ81982.1 CUQ81982.1 nifH1_2 nifH1_2 CUQ82015.1 CUQ82015.1 nifD nifD queH queH asd2 asd2 cobK cobK CUQ82240.1 CUQ82240.1 tyrC tyrC CUQ82392.1 CUQ82392.1 nrdD nrdD CUQ82412.1 CUQ82412.1 argC argC hemZ_1 hemZ_1 ypfD ypfD flr_1 flr_1 garR_1 garR_1 CUQ82776.1 CUQ82776.1 gpsA gpsA drgA drgA CUQ82976.1 CUQ82976.1 fadH fadH dhaD dhaD queF queF CUQ83044.1 CUQ83044.1 hcp hcp CUQ83124.1 CUQ83124.1 rbr3A rbr3A gltD_3 gltD_3 bdhA_1 bdhA_1 CUQ84250.1 CUQ84250.1 dhaT dhaT CUQ84357.1 CUQ84357.1 CUQ84425.1 CUQ84425.1 CUQ84441.1 CUQ84441.1 murB murB yghZ yghZ CUQ84824.1 CUQ84824.1 hrb hrb pflA_2 pflA_2 aroE_1 aroE_1 CUQ84939.1 CUQ84939.1 dus_1 dus_1 CUQ85315.1 CUQ85315.1 nadB_1 nadB_1 ydeM ydeM hom_1 hom_1 dfrD dfrD CUQ85847.1 CUQ85847.1 panE panE dus_2 dus_2 fabG_2 fabG_2 dapB dapB hom_2 hom_2 ddh ddh dxr dxr adhE_1 adhE_1 rnfC_1 rnfC_1 gutB_1 gutB_1 sucD sucD hpdA hpdA CUQ86906.1 CUQ86906.1 nqo1 nqo1 nuoE nuoE fabG_3 fabG_3 adhE_2 adhE_2 fprA1 fprA1 fabG_4 fabG_4 CUQ87372.1 CUQ87372.1 porA porA hcrA_1 hcrA_1 cutM cutM cutS cutS flr_2 flr_2 CUQ87886.1 CUQ87886.1 folD folD adhE_3 adhE_3 pyrK_1 pyrK_1 gltD_4 gltD_4 CUQ88140.1 CUQ88140.1 ywqN ywqN CUQ88340.1 CUQ88340.1 CUQ88346.1 CUQ88346.1 strL strL hisD hisD actIII actIII rnfB rnfB rnfA rnfA rnfG rnfG nqrB nqrB rnfC_2 rnfC_2 rpsA rpsA ispH ispH CUQ88565.1 CUQ88565.1 icd icd serA_1 serA_1 leuB leuB trxB_1 trxB_1 lhgO lhgO rbr1 rbr1 CUQ88953.1 CUQ88953.1 gdhA gdhA metF metF ilvC ilvC CUQ89273.1 CUQ89273.1 CUQ89632.1 CUQ89632.1 dkgA dkgA CUQ89691.1 CUQ89691.1 nfrA2 nfrA2 CUQ90100.1 CUQ90100.1 hcrC hcrC hcrA_2 hcrA_2 proA_1 proA_1 CUQ90564.1 CUQ90564.1 trxB_2 trxB_2 proC proC CUQ91123.1 CUQ91123.1 pyrD pyrD pyrK_2 pyrK_2 iolS iolS gltD_5 gltD_5 garR_2 garR_2 gldA gldA serA_2 serA_2 garR_3 garR_3 gutB_2 gutB_2 nadB_2 nadB_2 aroE_2 aroE_2 yvgN yvgN CUQ92164.1 CUQ92164.1 atsB atsB CUQ92396.1 CUQ92396.1 fucO fucO CUQ92432.1 CUQ92432.1 CUQ92522.1 CUQ92522.1 CUQ92546.1 CUQ92546.1 aroE_3 aroE_3 bdhA_2 bdhA_2 fadB2 fadB2 CUQ93059.1 CUQ93059.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
frdBFumarate reductase iron-sulfur subunit. (225 aa)
CUQ80548.1Saccharopine dehydrogenase. (419 aa)
CUQ80621.1Putative NADPH-quinone reductase (modulator of drug activity B). (476 aa)
CUQ80628.1Iron hydrogenase 1. (578 aa)
gltD_1Glutamate synthase [NADPH] small chain. (610 aa)
pflA_1Pyruvate formate-lyase-activating enzyme. (248 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
gltBFerredoxin-dependent glutamate synthase 1. (1507 aa)
gltD_2Glutamate synthase [NADPH] small chain. (499 aa)
mopAldehyde oxidoreductase. (860 aa)
CUQ80814.1Uncharacterised protein. (432 aa)
spxARegulatory protein spx. (116 aa)
fabG_13-oxoacyl-[acyl-carrier-protein] reductase FabG. (264 aa)
algDGDP-mannose 6-dehydrogenase. (437 aa)
ydbDProbable manganese catalase. (140 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (339 aa)
maeBNADP-dependent malic enzyme. (382 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase. (373 aa)
CUQ81839.1Putative reductase; Belongs to the ArsC family. (113 aa)
nifH1_1Nitrogenase iron protein 1; Belongs to the NifH/BchL/ChlL family. (255 aa)
CUQ81982.1Nitrogenase molybdenum-cofactor biosynthesis protein NifE. (829 aa)
nifH1_2Nitrogenase iron protein 1; Belongs to the NifH/BchL/ChlL family. (258 aa)
CUQ82015.1Nitrogenase molybdenum-iron protein%2C alpha and beta chains. (461 aa)
nifDNitrogenase molybdenum-iron protein alpha chain. (372 aa)
queHUncharacterized BCR%2C COG1636; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (212 aa)
asd2Aspartate-semialdehyde dehydrogenase 2; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa)
cobKPrecorrin-6A reductase. (282 aa)
CUQ82240.1Uncharacterised protein. (515 aa)
tyrCArogenate dehydrogenase. (365 aa)
CUQ82392.1Flavodoxin. (141 aa)
nrdDAnaerobic ribonucleoside-triphosphate reductase. (719 aa)
CUQ82412.1Anaerobic ribonucleotide reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (179 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
hemZ_1Oxygen-independent coproporphyrinogen-III oxidase 2; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (385 aa)
ypfD30S ribosomal protein S1 homolog. (231 aa)
flr_1Flavoredoxin. (230 aa)
garR_12-hydroxy-3-oxopropionate reductase. (294 aa)
CUQ82776.1Coenzyme F420-reducing hydrogenase subunit beta. (387 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (337 aa)
drgANitroreductase A. (178 aa)
CUQ82976.1NADH oxidase. (641 aa)
fadH2%2C4-dienoyl-CoA reductase [NADPH]. (668 aa)
dhaDGlycerol dehydrogenase. (365 aa)
queFNADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (160 aa)
CUQ83044.1Alcohol dehydrogenase. (344 aa)
hcpHydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (534 aa)
CUQ83124.14-carboxymuconolactone decarboxylase. (255 aa)
rbr3ANADH peroxidase. (180 aa)
gltD_3Glutamate synthase [NADPH] small chain. (920 aa)
bdhA_1NADH-dependent butanol dehydrogenase A. (395 aa)
CUQ84250.1NADH oxidase. (1154 aa)
dhaT1%2C3-propanediol dehydrogenase. (423 aa)
CUQ84357.1NADH dehydrogenase subunit I. (254 aa)
CUQ84425.1Flavodoxin. (167 aa)
CUQ84441.12-dehydropantoate 2-reductase. (300 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (301 aa)
yghZL-glyceraldehyde 3-phosphate reductase. (330 aa)
CUQ84824.1Rubredoxin; Belongs to the rubredoxin family. (51 aa)
hrbNitric oxide reductase NADH:FprA oxidoreductase. (206 aa)
pflA_2Pyruvate formate-lyase 1-activating enzyme. (279 aa)
aroE_1Shikimate dehydrogenase. (291 aa)
CUQ84939.1NADH oxidase. (656 aa)
dus_1Probable tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (321 aa)
CUQ85315.1HEAT repeat. (395 aa)
nadB_1L-aspartate oxidase. (415 aa)
ydeMAnaerobic sulfatase-maturating enzyme homolog YdeM. (466 aa)
hom_1Homoserine dehydrogenase. (425 aa)
dfrDDihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (162 aa)
CUQ85847.1Xanthine dehydrogenase accessory protein XdhC. (324 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (318 aa)
dus_2Probable tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (313 aa)
fabG_23-oxoacyl-[acyl-carrier-protein] reductase FabG. (252 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa)
hom_2Homoserine dehydrogenase. (405 aa)
ddhMeso-diaminopimelate D-dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (328 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (380 aa)
adhE_1Aldehyde-alcohol dehydrogenase. (382 aa)
rnfC_1Nitrogen fixation protein rnfC. (448 aa)
gutB_1Sorbitol dehydrogenase. (404 aa)
sucDSuccinate-semialdehyde dehydrogenase (acetylating). (462 aa)
hpdA4-hydroxyphenylacetate decarboxylase activating enzyme. (264 aa)
CUQ86906.1Iron hydrogenase 1. (564 aa)
nqo1NADH-quinone oxidoreductase subunit 1. (622 aa)
nuoENADH-quinone oxidoreductase subunit E. (159 aa)
fabG_33-oxoacyl-[acyl-carrier-protein] reductase FabG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (243 aa)
adhE_2Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (879 aa)
fprA1H(2)O-forming NADH oxidase. (385 aa)
fabG_43-oxoacyl-[acyl-carrier-protein] reductase FabG; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa)
CUQ87372.1Nitronate monooxygenase. (312 aa)
porAPyruvate synthase subunit porA. (1190 aa)
hcrA_14-hydroxybenzoyl-CoA reductase subunit alpha. (769 aa)
cutMCarbon monoxide dehydrogenase medium chain. (295 aa)
cutSCarbon monoxide dehydrogenase small chain. (168 aa)
flr_2Flavoredoxin. (168 aa)
CUQ87886.1Uncharacterised protein. (80 aa)
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa)
adhE_3Aldehyde-alcohol dehydrogenase. (393 aa)
pyrK_1Dihydrdoorotate oxidase B%2C electron transfer subunit. (295 aa)
gltD_4Glutamate synthase [NADPH] small chain. (462 aa)
CUQ88140.1Putative mercuric reductase. (406 aa)
ywqNPutative NAD(P)H-dependent FMN-containing oxidoreductase ywqN. (174 aa)
CUQ88340.1Uncharacterized conserved protein. (83 aa)
CUQ88346.1Uncharacterized conserved protein. (64 aa)
strLdTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (283 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
actIIIPutative ketoacyl reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (252 aa)
rnfBNitrogen fixation protein rnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (265 aa)
rnfAElectron transport complex protein rnfA. (204 aa)
rnfGElectron transport complex protein RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family. (204 aa)
nqrBNa(+)-translocating NADH-quinone reductase subunit B. (310 aa)
rnfC_2Nitrogen fixation protein rnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (439 aa)
rpsA30S ribosomal protein S1. (358 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (284 aa)
CUQ88565.1Tricarballylate dehydrogenase. (411 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (398 aa)
serA_1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (387 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (361 aa)
trxB_1Thioredoxin reductase. (421 aa)
lhgOL-2-hydroxyglutarate oxidase LhgO. (486 aa)
rbr1NADH peroxidase. (202 aa)
CUQ88953.1NAD(P)H-dependent FMN reductase. (209 aa)
gdhANADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa)
metF5%2C10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (289 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
CUQ89273.1Ferredoxin. (386 aa)
CUQ89632.1Bacterial mobilisation protein (MobC). (107 aa)
dkgA2%2C5-diketo-D-gluconic acid reductase A. (334 aa)
CUQ89691.1C_GCAxxG_C_C family protein. (137 aa)
nfrA2FMN reductase [NAD(P)H]. (172 aa)
CUQ90100.1Putative oxidoreductase. (271 aa)
hcrC4-hydroxybenzoyl-CoA reductase subunit gamma. (164 aa)
hcrA_24-hydroxybenzoyl-CoA reductase subunit alpha. (788 aa)
proA_1Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa)
CUQ90564.1Ferredoxin I. (203 aa)
trxB_2Thioredoxin reductase. (307 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa)
CUQ91123.1Thioredoxin C-1; Belongs to the thioredoxin family. (102 aa)
pyrDDihydroorotate dehydrogenase B (NAD(+))%2C catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (300 aa)
pyrK_2Dihydrdoorotate oxidase B%2C electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (260 aa)
iolS2%2C5-diketo-D-gluconate reductase B. (285 aa)
gltD_5Glutamate synthase [NADPH] small chain. (408 aa)
garR_22-hydroxy-3-oxopropionate reductase. (296 aa)
gldAGlycerol dehydrogenase. (362 aa)
serA_2D-3-phosphoglycerate dehydrogenase. (316 aa)
garR_32-hydroxy-3-oxopropionate reductase. (296 aa)
gutB_2Sorbitol dehydrogenase. (342 aa)
nadB_2L-aspartate oxidase. (523 aa)
aroE_2Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (291 aa)
yvgNGlyoxal reductase. (281 aa)
CUQ92164.1PUA domain (predicted RNA-binding domain). (155 aa)
atsBAnaerobic sulfatase-maturating enzyme. (344 aa)
CUQ92396.1Nitronate monooxygenase. (354 aa)
fucOLactaldehyde reductase. (381 aa)
CUQ92432.1Major membrane immunogen%2C membrane-anchored lipoprotein. (177 aa)
CUQ92522.1Nitroreductase A. (178 aa)
CUQ92546.1Putative 2-hydroxyacid dehydrogenase HI_1556; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (310 aa)
aroE_3Shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (104 aa)
bdhA_2NADH-dependent butanol dehydrogenase A. (396 aa)
fadB23-hydroxybutyryl-CoA dehydrogenase. (292 aa)
CUQ93059.1NADH oxidase. (135 aa)
Your Current Organism:
Ruminococcus torques
NCBI taxonomy Id: 33039
Other names: ATCC 27756, [. torques, [Ruminococcus] torques
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