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| | cobD_1 | Threonine-phosphate decarboxylase. (349 aa) |
| | pheT | Phenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (806 aa) |
| | pheS | Phenylalanine--tRNA ligase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (339 aa) |
| | thrC | Threonine synthase. (495 aa) |
| | asd2 | Aspartate-semialdehyde dehydrogenase 2; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa) |
| | argH | Argininosuccinate lyase. (459 aa) |
| | pdxT | Glutamine amidotransferase subunit pdxT. (192 aa) |
| | ispD1 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (230 aa) |
| | yxeP | Uncharacterized hydrolase YxeP. (392 aa) |
| | ispF | 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (179 aa) |
| | glyA | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase. (373 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (355 aa) |
| | tdcB | L-threonine dehydratase catabolic TdcB. (404 aa) |
| | acpP_1 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (347 aa) |
| | lysA_2 | Diaminopimelate decarboxylase. (423 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa) |
| | gpmI | 2%2C3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa) |
| | mtnN | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | CUQ81382.1 | Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (273 aa) |
| | nifS | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (396 aa) |
| | gltX | Glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (485 aa) |
| | purF | Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa) |
| | asnB_1 | Asparagine synthetase [glutamine-hydrolyzing] 1. (626 aa) |
| | CUQ80777.1 | Uncharacterised protein. (348 aa) |
| | asnA | Aspartate--ammonia ligase. (336 aa) |
| | gltD_2 | Glutamate synthase [NADPH] small chain. (499 aa) |
| | gltB | Ferredoxin-dependent glutamate synthase 1. (1507 aa) |
| | alaS_1 | Alanine--tRNA ligase. (404 aa) |
| | argS | Arginine--tRNA ligase. (587 aa) |
| | iscS | Cysteine desulfurase. (385 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (622 aa) |
| | CUQ80490.1 | Conserved hypothetical integral membrane protein. (203 aa) |
| | CUQ93375.1 | Uncharacterised protein. (111 aa) |
| | metB | Cystathionine gamma-synthase. (243 aa) |
| | mdeA_2 | Methionine gamma-lyase. (435 aa) |
| | cysK | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa) |
| | CUQ93304.1 | Uncharacterised protein. (112 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (253 aa) |
| | nfdA | N-substituted formamide deformylase precursor. (517 aa) |
| | nagB_2 | Glucosamine-6-phosphate deaminase 1; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (241 aa) |
| | CUQ92838.1 | Uncharacterised ACR%2C YkgG family COG1556. (211 aa) |
| | pfkA_2 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (339 aa) |
| | thlA | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | fadB2 | 3-hydroxybutyryl-CoA dehydrogenase. (292 aa) |
| | aroE_3 | Shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (104 aa) |
| | CUQ92546.1 | Putative 2-hydroxyacid dehydrogenase HI_1556; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (310 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (372 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (226 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa) |
| | CUQ92164.1 | PUA domain (predicted RNA-binding domain). (155 aa) |
| | yvgN | Glyoxal reductase. (281 aa) |
| | guaA_2 | GMP synthase [glutamine-hydrolyzing]. (70 aa) |
| | aroK_2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (261 aa) |
| | aroE_2 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (291 aa) |
| | metC | Cystathionine beta-lyase metC. (131 aa) |
| | metG | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (633 aa) |
| | guaA_1 | GMP synthase [glutamine-hydrolyzing]. (515 aa) |
| | CUQ91742.1 | Phosphoserine phosphatase. (200 aa) |
| | CUQ91669.1 | Beta-lactamase superfamily domain. (228 aa) |
| | gutB_2 | Sorbitol dehydrogenase. (342 aa) |
| | garD | D-galactarate dehydratase. (505 aa) |
| | dapA_2 | Dihydrodipicolinate synthase; Belongs to the DapA family. (295 aa) |
| | gudD | Glucarate dehydratase; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (441 aa) |
| | serA_2 | D-3-phosphoglycerate dehydrogenase. (316 aa) |
| | gltD_5 | Glutamate synthase [NADPH] small chain. (408 aa) |
| | iolS | 2%2C5-diketo-D-gluconate reductase B. (285 aa) |
| | dapL | LL-diaminopimelate aminotransferase. (400 aa) |
| | thiH_2 | 2-iminoacetate synthase. (357 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa) |
| | dltB_2 | D-alanyl-lipoteichoic acid biosynthesis protein DltB; Belongs to the membrane-bound acyltransferase family. (469 aa) |
| | bacD | Alanine-anticapsin ligase BacD. (405 aa) |
| | hisH1 | Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) |
| | hisF_2 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hgdC_2 | 2-hydroxyglutaryl-CoA dehydratase component A. (258 aa) |
| | bcrB | Benzoyl-CoA reductase subunit B. (383 aa) |
| | ppdK | Pyruvate%2C phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (876 aa) |
| | glyQS | Glycine--tRNA ligase. (466 aa) |
| | proA_1 | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa) |
| | hcrA_2 | 4-hydroxybenzoyl-CoA reductase subunit alpha. (788 aa) |
| | hcrC | 4-hydroxybenzoyl-CoA reductase subunit gamma. (164 aa) |
| | dapA_1 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | CUQ89691.1 | C_GCAxxG_C_C family protein. (137 aa) |
| | eno_2 | Enolase. (232 aa) |
| | dkgA | 2%2C5-diketo-D-gluconic acid reductase A. (334 aa) |
| | CUQ89606.1 | Conserved hypothetical integral membrane protein. (193 aa) |
| | cysE | Serine acetyltransferase. (231 aa) |
| | cysS | Cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (468 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa) |
| | glnS | Glutamine--tRNA ligase. (556 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (306 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (526 aa) |
| | ilvH_2 | Acetolactate synthase isozyme 3 small subunit. (165 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | argR | Arginine hydroxamate resistance protein; Regulates arginine biosynthesis genes. (152 aa) |
| | metF | 5%2C10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (289 aa) |
| | CUQ89016.1 | Vitamin B12 dependent methionine synthase%2C activation domain. (216 aa) |
| | metH | Methionine synthase. (798 aa) |
| | alaS_2 | Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (879 aa) |
| | gdhA | NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa) |
| | lysC | Aspartokinase 2; Belongs to the aspartokinase family. (400 aa) |
| | asnB_2 | Asparagine synthetase [glutamine-hydrolyzing] 1. (512 aa) |
| | cobD_2 | Threonine-phosphate decarboxylase. (363 aa) |
| | pfp | Pyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (417 aa) |
| | CUQ88790.1 | Oleate hydratase. (665 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (370 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (361 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa) |
| | ilvG | Acetolactate synthase isozyme 2 large subunit. (561 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa) |
| | serA_1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (387 aa) |
| | icd | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (398 aa) |
| | accD5 | Probable propionyl-CoA carboxylase beta chain 5. (479 aa) |
| | gcdC | Glutaconyl-CoA decarboxylase subunit gamma. (122 aa) |
| | CUQ88565.1 | Tricarballylate dehydrogenase. (411 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (284 aa) |
| | rpsA | 30S ribosomal protein S1. (358 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (419 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (214 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (196 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase; In the C-terminal section; belongs to the PRA-PH family. (426 aa) |
| | thrA | Aspartokinase I/homoserine dehydrogenase I; Belongs to the aspartokinase family. (439 aa) |
| | CUQ88140.1 | Putative mercuric reductase. (406 aa) |
| | gltD_4 | Glutamate synthase [NADPH] small chain. (462 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa) |
| | mdeA_1 | Methionine gamma-lyase. (425 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (388 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (662 aa) |
| | tyrS | Tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (407 aa) |
| | cutS | Carbon monoxide dehydrogenase small chain. (168 aa) |
| | cutM | Carbon monoxide dehydrogenase medium chain. (295 aa) |
| | hcrA_1 | 4-hydroxybenzoyl-CoA reductase subunit alpha. (769 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Belongs to the thiolase-like superfamily. FabH family. (315 aa) |
| | acpP_2 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (91 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase. (306 aa) |
| | fabF | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (163 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (572 aa) |
| | asnS_2 | Asparagine--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (443 aa) |
| | abgB | Aminobenzoyl-glutamate utilization protein B. (438 aa) |
| | selD | Selenide%2C water dikinase. (293 aa) |
| | csd | Probable cysteine desulfurase. (375 aa) |
| | trpS2 | Tryptophan--tRNA ligase 2; Belongs to the class-I aminoacyl-tRNA synthetase family. (361 aa) |
| | gutB_1 | Sorbitol dehydrogenase. (404 aa) |
| | valS | Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (881 aa) |
| | carB | Carbamoyl-phosphate synthase large chain. (1067 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (374 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (380 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase. (337 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (353 aa) |
| | ddh | Meso-diaminopimelate D-dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (328 aa) |
| | hacA | Homoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa) |
| | DmdB_2 | 2%2C3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa) |
| | dmdA_2 | 2%2C3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa) |
| | DmdB_1 | 2%2C3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (159 aa) |
| | hom_2 | Homoserine dehydrogenase. (405 aa) |
| | hisF_1 | Imidazole glycerol phosphate synthase subunit HisF; Belongs to the HisA/HisF family. (257 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (538 aa) |
| | thrS | Threonine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (650 aa) |
| | proB | Glutamate 5-kinase 1; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (265 aa) |
| | panE | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (318 aa) |
| | CUQ85880.1 | Molybdopterin-guanine dinucleotide biosynthesis protein MobA. (462 aa) |
| | dpaL | Diaminopropionate ammonia-lyase. (401 aa) |
| | dapE_2 | Probable succinyl-diaminopimelate desuccinylase. (436 aa) |
| | ygeW | Aspartate/ornithine carbamoyltransferase family protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (398 aa) |
| | arcC1_1 | Carbamate kinase 1; Belongs to the carbamate kinase family. (314 aa) |
| | ilvH_1 | Acetolactate synthase isozyme 3 small subunit. (169 aa) |
| | ilvB | Acetolactate synthase large subunit. (572 aa) |
| | dfrD | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (162 aa) |
| | hom_1 | Homoserine dehydrogenase. (425 aa) |
| | aspS | Aspartate--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (600 aa) |
| | hisS | Histidine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (421 aa) |
| | nanA | N-acetylneuraminate lyase. (305 aa) |
| | nanE | Putative N-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (229 aa) |
| | nagB_1 | Glucosamine-6-phosphate deaminase 1; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (243 aa) |
| | CUQ85470.1 | Uncharacterized phage-encoded protein. (330 aa) |
| | CUQ85380.1 | ORF6N domain. (346 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (301 aa) |
| | nadC | Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]; Belongs to the NadC/ModD family. (284 aa) |
| | asnS_1 | Asparagine--tRNA ligase. (463 aa) |
| | aroK_1 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (331 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (330 aa) |
| | acpA | Acyl carrier protein. (74 aa) |
| | fadD_1 | Long-chain-fatty-acid--CoA ligase. (510 aa) |
| | lysS | Lysine--tRNA ligase. (687 aa) |
| | aroE_1 | Shikimate dehydrogenase. (291 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (291 aa) |
| | CUQ84782.1 | Acyl-ACP thioesterase. (236 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase. (341 aa) |
| | dapE_1 | Probable succinyl-diaminopimelate desuccinylase. (387 aa) |
| | proS | Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (478 aa) |
| | CUQ84441.1 | 2-dehydropantoate 2-reductase. (300 aa) |
| | coaBC | DNA/pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa) |
| | CUQ84295.1 | D-alanine--poly(phosphoribitol) ligase subunit 2. (75 aa) |
| | lysA_3 | Diaminopimelate decarboxylase. (401 aa) |
| | dltB_1 | D-alanyl-lipoteichoic acid biosynthesis protein DltB; Belongs to the membrane-bound acyltransferase family. (528 aa) |
| | crnA | Creatinine amidohydrolase. (247 aa) |
| | CUQ84165.1 | Serine dehydratase alpha chain; Belongs to the UPF0597 family. (429 aa) |
| | panD | Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (130 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa) |
| | serS | Serine--tRNA ligase. (429 aa) |
| | pfkA_1 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (359 aa) |
| | ileS | Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1051 aa) |
| | iadA | Isoaspartyl dipeptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. Belongs to the peptidase M38 family. (382 aa) |
| | CUQ83044.1 | Alcohol dehydrogenase. (344 aa) |
| | pheA | P-protein. (380 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase%2C Phe-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (343 aa) |
| | eno_1 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | ltaE | Low specificity L-threonine aldolase. (341 aa) |
| | ypfD | 30S ribosomal protein S1 homolog. (231 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (300 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa) |
| | leuS | Leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (810 aa) |
| | tyrC | Arogenate dehydrogenase. (365 aa) |
| | aroA1 | 3-phosphoshikimate 1-carboxyvinyltransferase 1; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa) |
| | sulD | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (278 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (271 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. (644 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (401 aa) |
| | bioD1 | ATP-dependent dethiobiotin synthetase BioD 1; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa) |
| | cobB_1 | Cobyrinic acid A%2CC-diamide synthase. (494 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa) |
| | arcC1_2 | Carbamate kinase 1; Belongs to the carbamate kinase family. (309 aa) |
