(56 nodes) 4 iron, 4 sulfur cluster binding network (Ruminococcus torques)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CUQ80463.1	Radical SAM superfamily. (302 aa)
	CUQ80628.1	Iron hydrogenase 1. (578 aa)
	gltD_1	Glutamate synthase [NADPH] small chain. (610 aa)
	pflA_1	Pyruvate formate-lyase-activating enzyme. (248 aa)
	moaA_1	Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
	miaB_1	(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB. (450 aa)
	rlmCD_1	23S rRNA (uracil-C(5))-methyltransferase RlmCD; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (559 aa)
	purF	Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa)
	CUQ81506.1	Radical SAM protein. (315 aa)
	ispG	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase. (373 aa)
	nifH1_1	Nitrogenase iron protein 1; Belongs to the NifH/BchL/ChlL family. (255 aa)
	nifH1_2	Nitrogenase iron protein 1; Belongs to the NifH/BchL/ChlL family. (258 aa)
	queH	Uncharacterized BCR%2C COG1636; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (212 aa)
	CUQ82412.1	Anaerobic ribonucleotide reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (179 aa)
	hemZ_1	Oxygen-independent coproporphyrinogen-III oxidase 2; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (385 aa)
	ypfD	30S ribosomal protein S1 homolog. (231 aa)
	rimO	Ribosomal protein S12 methylthiotransferase RimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (440 aa)
	queE	7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (216 aa)
	CUQ83034.1	Probable DNA metabolism protein. (255 aa)
	hcp	Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (534 aa)
	ttdA_1	L(+)-tartrate dehydratase subunit alpha. (281 aa)
	gltD_3	Glutamate synthase [NADPH] small chain. (920 aa)
	sdhA	L-serine dehydratase%2C alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (289 aa)
	sdhB	L-serine dehydratase%2C beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (222 aa)
	CUQ84357.1	NADH dehydrogenase subunit I. (254 aa)
	pflA_2	Pyruvate formate-lyase 1-activating enzyme. (279 aa)
	bioB	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (331 aa)
	CUQ85326.1	Uncharacterised protein. (429 aa)
	nadA	Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (301 aa)
	CUQ85390.1	Uncharacterised protein. (105 aa)
	rlmCD_2	23S rRNA (uracil-C(5))-methyltransferase RlmCD; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (464 aa)
	ydeM	Anaerobic sulfatase-maturating enzyme homolog YdeM. (466 aa)
	dmdA_2	2%2C3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa)
	hacA	Homoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa)
	thiC	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (436 aa)
	rnfC_1	Nitrogen fixation protein rnfC. (448 aa)
	hpdA	4-hydroxyphenylacetate decarboxylase activating enzyme. (264 aa)
	CUQ86906.1	Iron hydrogenase 1. (564 aa)
	nqo1	NADH-quinone oxidoreductase subunit 1. (622 aa)
	mutY	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (361 aa)
	porA	Pyruvate synthase subunit porA. (1190 aa)
	rlmN	Ribosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (346 aa)
	miaB_2	(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (482 aa)
	CUQ88406.1	Uncharacterized radical SAM protein YgiQ. (655 aa)
	rnfB	Nitrogen fixation protein rnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (265 aa)
	rnfC_2	Nitrogen fixation protein rnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (439 aa)
	rpsA	30S ribosomal protein S1. (358 aa)
	ispH	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (284 aa)
	CUQ92803.1	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (56 aa)
	atsB	Anaerobic sulfatase-maturating enzyme. (344 aa)
	CUQ92164.1	PUA domain (predicted RNA-binding domain). (155 aa)
	addB	ATP-dependent helicase/deoxyribonuclease subunit B; ATP-dependent DNA helicase. (1123 aa)
	nth	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa)
	thiH_2	2-iminoacetate synthase. (357 aa)
	ttdA_2	L(+)-tartrate dehydratase subunit alpha. (299 aa)
	bcrB	Benzoyl-CoA reductase subunit B. (383 aa)

Your Current Organism:

Ruminococcus torques

NCBI taxonomy Id: 33039
Other names: ATCC 27756, [. torques, [Ruminococcus] torques

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUQ80628.1	CUQ86906.1	ERS852502_00059	ERS852502_01438	Iron hydrogenase 1.	Iron hydrogenase 1.	0.511
CUQ80628.1	CUQ92803.1	ERS852502_00059	ERS852502_02712	Iron hydrogenase 1.	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	0.606
CUQ80628.1	bioB	ERS852502_00059	ERS852502_01086	Iron hydrogenase 1.	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.466
CUQ80628.1	gltD_1	ERS852502_00059	ERS852502_00060	Iron hydrogenase 1.	Glutamate synthase [NADPH] small chain.	0.998
CUQ80628.1	gltD_3	ERS852502_00059	ERS852502_00856	Iron hydrogenase 1.	Glutamate synthase [NADPH] small chain.	0.572
CUQ80628.1	nqo1	ERS852502_00059	ERS852502_01439	Iron hydrogenase 1.	NADH-quinone oxidoreductase subunit 1.	0.998
CUQ80628.1	porA	ERS852502_00059	ERS852502_01562	Iron hydrogenase 1.	Pyruvate synthase subunit porA.	0.939
CUQ80628.1	rnfB	ERS852502_00059	ERS852502_01796	Iron hydrogenase 1.	Nitrogen fixation protein rnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.	0.803
CUQ80628.1	thiH_2	ERS852502_00059	ERS852502_02332	Iron hydrogenase 1.	2-iminoacetate synthase.	0.836
CUQ84357.1	gltD_3	ERS852502_00899	ERS852502_00856	NADH dehydrogenase subunit I.	Glutamate synthase [NADPH] small chain.	0.546
CUQ84357.1	porA	ERS852502_00899	ERS852502_01562	NADH dehydrogenase subunit I.	Pyruvate synthase subunit porA.	0.896
CUQ85390.1	rlmCD_2	ERS852502_01136	ERS852502_01163	Uncharacterised protein.	23S rRNA (uracil-C(5))-methyltransferase RlmCD; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.	0.763
CUQ86906.1	CUQ80628.1	ERS852502_01438	ERS852502_00059	Iron hydrogenase 1.	Iron hydrogenase 1.	0.511
CUQ86906.1	gltD_1	ERS852502_01438	ERS852502_00060	Iron hydrogenase 1.	Glutamate synthase [NADPH] small chain.	0.675
CUQ86906.1	nqo1	ERS852502_01438	ERS852502_01439	Iron hydrogenase 1.	NADH-quinone oxidoreductase subunit 1.	0.999
CUQ86906.1	porA	ERS852502_01438	ERS852502_01562	Iron hydrogenase 1.	Pyruvate synthase subunit porA.	0.756
CUQ86906.1	thiH_2	ERS852502_01438	ERS852502_02332	Iron hydrogenase 1.	2-iminoacetate synthase.	0.758
CUQ92803.1	CUQ80628.1	ERS852502_02712	ERS852502_00059	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Iron hydrogenase 1.	0.606
CUQ92803.1	nqo1	ERS852502_02712	ERS852502_01439	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	NADH-quinone oxidoreductase subunit 1.	0.628
CUQ92803.1	porA	ERS852502_02712	ERS852502_01562	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Pyruvate synthase subunit porA.	0.958